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Ticlopidine, Platelets and Vascular Disease

Author: William K. Hass

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 226

ISBN-13: 1461383064

Blood platelets lack a nucleus. As a result their life span is short and they cannot reproduce themselves. Platelets share these qualities with the red blood cell. Plate lets and red blood cells, nevertheless, serve vital roles in the body. One major function of the platelet is its capacity to aggregate and thereby initiate intravas cular coagulation which often underlies such major diseases as myocardial infarc tion, cerebral infarction, and pulmonary embolism. For this reason in recent years, medical attention has been directed to drugs that inhibit platelet aggregation. Aspirin was the first drug to be proven effective in this area. Since then other drugs that share aspirin's fundamental biochemical action, inhibition of platelet cyclooxygenase, have also been studied. Very recently, ticlopidine, the first of what promises to be a new class of drugs inhibiting platelet aggregation and coagulation via an entirely different biochemical mechanism, has been exten sively studied and clinically shown to be as effective or more effective than aspirin in the prevention of ischemic cardiovascular and cerebrovascular disease.

Platelets in Cardiovascular Disease

Author: Deepak L. Bhatt

Publisher: Imperial College Press

Published: 2008

Total Pages: 235

ISBN-13: 1860948529

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Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives.

Ticlopidine

Author: J. R. O'Brien

Publisher: S. Karger AG (Switzerland)

Published: 1983

Total Pages: 64

ISBN-13:

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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease

Author: A. Michael Lincoff

Publisher: Springer Science & Business Media

Published: 2003-03-07

Total Pages: 471

ISBN-13: 1592593763

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This substantially revised second edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes or with fibrinolytic therapy during acute myocardial infarctions, and updated and expanded information on the latest trials of GP IIb/IIIa inhibition during percutaneous coronary intervention. Additional improvements include a new chapter on outcomes with chronic oral GP IIb/IIIa blockade following acute coronary syndromes, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation.

Mechanisms of Vascular Disease

Author: Robert Fitridge

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 589

ISBN-13: 1922064009

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Platelets and Prostaglandins in Cardiovascular Disease

Author: Jawahar Mehta

Publisher: Wiley-Blackwell

Published: 1981

Total Pages: 466

ISBN-13:

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Practical Cardiology

Author: Majid Maleki

Publisher: Elsevier Health Sciences

Published: 2017-08-25

Total Pages: 400

ISBN-13: 0323511767

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From basic clinical facts to new advanced guidelines, Practical Cardiology, by Drs. Majid Maleki, Azin Alizadehasl, and Majid Haghjoo, is your new go-to resource for new developments in cardiology knowledge, imaging modalities, management techniques, and more. This step-by-step, practical reference is packed with tips and guidance ideal for residents, fellows, and clinicians in cardiology, as well as internal medicine, cardiac surgery, interventional cardiology, and pediatric cardiology. Features a wealth of information, including practical points from recently published guidelines, ECGs, hemodynamic traces of advanced imaging modalities in real patients, and much more. Offers a comprehensive review of cardiovascular medicine, from basic to advanced.

Side Effects of Drugs Annual

Author: Jeffrey K. Aronson

Publisher: Elsevier

Published: 2011-08-19

Total Pages: 715

ISBN-13: 0080522815

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The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the Annuals by selecting critically from each year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is misleading. Provides a critical yearly survey of new data and trends Includes an essay that describes the modern approach to classifying adverse drug reactions Special reviews in this Annual include, among other topics: Antipsychotic drugs and now-onset diabetes mellitus, Treating asthma during pregnancy, and MMR vaccine and autism

Office Practice of Neurology

Author: Martin A. Samuels

Publisher:

Published: 2003

Total Pages: 1572

ISBN-13:

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This comprehensive text is the perfect clinical resource, offering quick access to all of the information needed to provide out-patient neurologic care. It focuses on the common and chronic problems that require long-term management, and provides step-by-step guidance on the decision-making process. Readers will find an expanded section on multiple sclerosis as well as updated and revised information in every section, including all of the latest studies and their results. Plus, a table at the beginning of each chapter summarizes the authors' approaches to diagnosis and management. Features contributions from more than 200 authors, representing a wide spectrum of specialists in neurology and related fields. Covers the major problems that any practicing neurologist might encounter, including those that may be rare. Presents a wealth of useful clinical information with enough comprehensive coverage on the difficult, long-term, and complicated disorders. Features an expanded section on multiple sclerosis, with in-depth discussions on the clinical issues surrounding the disease. Discusses the latest molecular genetic studies, including new information on the progressive ataxias · Alzheimer's disease · Huntington's disease · mitochondrial disorders · and familial stroke and headache syndromes. Reports on the results of recent clinical studies on asymptomatic carotid atherosclerosis and symptomatic carotid endarterectomy. Includes the latest methods for treating stroke · seizures · multiple sclerosis · migraine · Parkinson's disease · amyotrophic lateral sclerosis · and Alzheimer's disease. Presents a summary table at the beginning of each chapter, highlighting the authors' approaches to various problems of diagnosis and management.

Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease

Author: A. Michael Lincoff

Publisher: Springer Science & Business Media

Published: 1999-03-04

Total Pages: 415

ISBN-13: 1592597246

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In Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, the major investigators working in this rapidly advancing field join together under the aegis of A. Michael Lincoff and Eric J. Topol to provide the first comprehensive overview of the preclinical and clinical development of the glycoprotein IIb/IIIa receptor antagonists. These acknowledged experts elucidate the theoretical basis for the inhibition of platelet aggregation in the treatment of coronary syndromes, present and synthesize evidence for the efficacy of glycoprotein IIb/IIIa blockade in inhibiting ischemic complications of both coronary intervention and acute coronary syndromes, and provide guidelines for the use of this novel class of agents in the clinical management of cardiovascular disease. They also compare the pharmacology and clinical efficacy of the currently available glycoprotein IIb/IIIa receptor inhibitors and speculate about further potential applications of these agents in the treatment of vascular disease. Written by the scientists and physicians who discovered and characterized this important new class of receptors, invented the first IIb/IIIa agents, and conducted the definitive clinical trials, Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease offers the most complete and authoritative review of these powerful new therapeutics available today.