Heparin and Related Polysaccharides

Heparin and Related Polysaccharides PDF

Author: David A. Lane

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 372

ISBN-13: 1489924442

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This volume is a record of a meeting entitled "Heparin and Related Polysaccharides" that was held at the Biomedical Center, Uppsala, Sweden between 1-6 September 1991. The meeting was hosted by U. Lindahl, L. Kjellen and I. Bjork, who were helped in their preparations by a scientific advisory panel that included U. Abildgaard, B. Casu, E. Holmer and D. Lane. Altogether, 230 participants from 18 countries attended the meeting, and most were present to be included in a photograph, which is to be found at the end of this volume. The selection of presentations for inclusion in the Symposia of the meeting was made on the basis of the known high quality of the work of the individuals or groups involved. This, we believe, is reflected in the contents of the enclosed articles, which collectively give a comprehensive overview of the present state of knowledge of heparin and related compounds. Some of the areas covered are evolving or controversial and the views expressed in each article should be regarded as those of the author(s). The authors have taken various amounts of care to define all their abbreviations and some familiarity with the different forms of nomenclature used in the fields of polysaccharide chemistry and of the coagulation proteinases and their inhibitors will assist the reader.

Chemistry and Biology of Heparin and Heparan Sulfate

Chemistry and Biology of Heparin and Heparan Sulfate PDF

Author: Hari G. Garg

Publisher: Elsevier

Published: 2011-10-10

Total Pages: 793

ISBN-13: 0080529054

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The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

NMR in Glycoscience and Glycotechnology

NMR in Glycoscience and Glycotechnology PDF

Author: Koichi Kato

Publisher: Royal Society of Chemistry

Published: 2017-05-15

Total Pages: 402

ISBN-13: 1782623949

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This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Methods to Investigate the Non-anticoagulant Functions of Heparin and Related Polysaccharides

Methods to Investigate the Non-anticoagulant Functions of Heparin and Related Polysaccharides PDF

Author: John Hogwood

Publisher:

Published: 2019

Total Pages: 0

ISBN-13:

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Background: There is increased interest in the development of heparin and related polysaccharides for clinical indications beyond their current anticoagulant remit. These indications range from anti-inflammatory and anti-complement agents, anti-metastatic therapeutics, prevention of protracted labour and easing pulmonary conditions such as chronic pulmonary obstructive disease and asthma. Anticoagulant activity may not be necessary and may cause adverse side effects when heparin is used for these conditions. Removal of anticoagulant activity such as selective de-sulfation have been carried out by a few pharmaceutical manufacturers of heparin and some of these products are now in clinical trials. Currently there is limited information on the structure/function relationships between nonanticoagulant heparins and these indications. The aim of this project was to study the structure and function relationship between heparins for some of these new indications. Methods and results: Heparin materials with different structures were prepared and characterised using a range of physicochemical and biological assays. Three different nonanticoagulant functions of these heparin were investigated: 1/ Potential pro-inflammatory properties in the kallikrein-kinin system were investigated for sulfate modified heparin and chondroitin sulfates. Of the samples investigated only oversulfated chondroitin sulfates significantly increased generation of kallikrein and bradykinin, indicating a high degree of sulfation is required to stimulate the kallikrein-kinin system.

Heparin - A Century of Progress

Heparin - A Century of Progress PDF

Author: Rebecca Lever

Publisher: Springer Science & Business Media

Published: 2012-05-08

Total Pages: 457

ISBN-13: 3642230563

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Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

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