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Design and Applications of Microneedles in Drug Delivery and Therapeutics

Author: Prashant Kesharwani

Publisher: Elsevier

Published: 2024-07-01

Total Pages: 574

ISBN-13: 044313880X

Microneedles in Drug Delivery and Therapeutics details the design, characterization and applications of this novel drug delivery system.Microneedles offer several advantages over traditional oral and parenteral approaches, due to their ability to be fabricated and altered in shape, size and material type, matched to specific treatment needs.This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including: cancer therapy, gene and vaccine delivery, wound healing and more. Microneedles in Drug Delivery and Therapeutics is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery. Introduces the reader to skin anatomy and materials development in regard to microneedles as smart carriers for drug delivery, offering an interdisciplinary approach that will appeal to a wide audience Covers a broad range of therapeutic applications, from ocular diseases and photodynamic therapy to sensing and cancer treatment Provides an overview of the materials, design, fabrication, clinical translation, commercial aspects of microneedle development, and their applications in drug delivery

Microneedles

Author: Hiep Xuan Nguyen

Publisher: CRC Press

Published: 2023-07-04

Total Pages: 448

ISBN-13: 100089780X

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The microneedle field has been expanding exponentially with innovative designs and various applications, thus capturing the interest of academic industry and regulatory sectors. Microneedles: The Future of Drug Delivery equips readers with a comprehensive understanding of microneedles: from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles. This book is written by a single author and thus provides complex information in a simple, elegant, and cohesive style. The book is intended for graduate students, researchers, scientists, and engineers working in the pharmaceutical, medical, cosmeceutical, and biotechnology industry.

Microneedle-mediated Transdermal and Intradermal Drug Delivery

Author: Ryan F. Donnelly

Publisher: John Wiley & Sons

Published: 2012-01-17

Total Pages: 238

ISBN-13: 1119959667

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Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

Microneedles

Author: Kevin Ita

Publisher: Academic Press

Published: 2022-02-06

Total Pages: 266

ISBN-13: 0323972349

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Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study. Provides information for the design and fabrication of microneedles Discusses choice of materials, fabrication protocol, sterilization protocol and characterization Supplies the most up-to-date research on all aspects of microneedles

Drug Delivery Devices and Therapeutic Systems

Author: Eric Chappel

Publisher: Academic Press

Published: 2020-11-07

Total Pages: 680

ISBN-13: 0128198397

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Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. Provides essential information on the most recent drug delivery systems available Explains current technology and its applications to drug delivery Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

Microneedles for Drug and Vaccine Delivery and Patient Monitoring

Author: Ryan F. Donnelly

Publisher: John Wiley & Sons

Published: 2018-08-20

Total Pages: 349

ISBN-13: 1119305144

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Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Optimisation of Microneedle Array Design for Microneedle Mediated Ionophoretic Transdermal Drug Delivery

Author: M. J. Garland

Publisher:

Published: 2012

Total Pages:

ISBN-13:

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The present study was designed to identify the most suitable polymeric microneedle (MN) array design for use as an electrically responsive device capable of providing both sustained and on-demand percutaneous drug delivery both in vitro and in vivo. Soluble MN arrays loaded with a range of small to large molecules were fabricated from aqueous blends of 20% w/w poly(methyl vinyl ether eo maleic acid) (PMVEIMA). Novel hydrogel forming MN arrays were fabricated from aqueous blends containing 15% w/w PMVEIMA and 7.5% w/w poly(ethyleneglycol) (PEG, M; = 10 kDa). MN arrays were fabricated in a laser-engineered micro-moulding process. Hydrogel MN arrays were integrated with drug loaded reservoir patches. Whilst the combination of iontophoresis with both polymeric MN systems led to enhanced transdermal delivery of all drug molecules investigated in vitro, the electro- responsive nature of the hydrogel forming MN arrays enabled the sustained passive delivery and the electrically stimulated bolus delivery of the proteins insulin and bovine serum albumin in vivo. As such, this system may have great potential for the pulsatile transdermal delivery of therapeutic peptide/protein agents.

Silk-based Drug Delivery Systems

Author: Elia Bari

Publisher: Royal Society of Chemistry

Published: 2020-10-07

Total Pages: 243

ISBN-13: 1788017722

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Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

Author: Ryan F. Donnelly

Publisher: John Wiley & Sons

Published: 2015-09-28

Total Pages: 290

ISBN-13: 1118734513

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This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Microneedles for Transdermal Drug Delivery

Author: Jaspreet Singh Kochhar

Publisher: Springer

Published: 2019-07-04

Total Pages: 156

ISBN-13: 3030154440

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This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data.