Experimental Models of Multiple Sclerosis

Experimental Models of Multiple Sclerosis PDF

Author: Ehud Lavi

Publisher: Springer Science & Business Media

Published: 2008-01-03

Total Pages: 892

ISBN-13: 0387255184

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Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

The Biology of Multiple Sclerosis

The Biology of Multiple Sclerosis PDF

Author: Gregory Atkins

Publisher: Cambridge University Press

Published: 2012-11-08

Total Pages: 141

ISBN-13: 1139851063

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Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.

Immune Regulation and Immunotherapy in Autoimmune Disease

Immune Regulation and Immunotherapy in Autoimmune Disease PDF

Author: Jingwu Zhang

Publisher: Springer Science & Business Media

Published: 2007-01-25

Total Pages: 580

ISBN-13: 0387360034

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This volume reviews the most recent advances in the understanding of cellular and molecular mechanisms for immune responses and immune regulation. The books editor, Dr. Zhang, is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis. He has much experience and expertise in both basic and clinical aspects of autoimmune disease.

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