-PDF Download- Viral And Immunological Malignancies EBOOK

Viral and Immunological Malignancies

Author: Paul Volberding

Publisher: PMPH-USA

Published: 2006

Total Pages: 440

ISBN-13: 9781550092561

The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.

Immunological Aspects of Viral Oncolysis

Author: Jean Lindenmann

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 91

ISBN-13: 3642870449

DOWNLOAD EBOOK →

mouse tissue alloantigen detected by this procedure. An antigen of cross-reacting specificity was revealed in tissue extracts of many other animal species. We next wanted to learn more about the antigen responsible for induction of postoncolytic immunity. Extracts from virus-infected tumors were immunogenic, and both active and inactive fractions of such extracts were obtained. The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one. We consider none of the questions which our work has raised as definitely solved. In fact, we are still working on many of the aspects alluded to above. When we embarked on a study of postoncolytic immunity, we were supported in this endeavor by our lack of experience in the fields of transplantation and tumor immunology.

Immune Deficiency and Cancer

Author: David T. Purtilo

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 489

ISBN-13: 1468447602

DOWNLOAD EBOOK →

The discoveries of Burkitt, Epstein, and Henle have laid the foundation for continuing generation of information regarding the mechanisms of induction of diseases by Epstein-Barr virus. The discovery of the virus two decades ago resulted from clinical and basic science collaborative studies on Burkitt lymphoma. Subse quently, nasopharyngeal carcinoma and infectious mononucleosis have been linked etiologically with the virus. During the first decade of research following the discovery of the virus, the mechanisms for the induction of BL, NPC, and IM were sought. At that time one prevailing view was that individual oncogenic strains of EBV were responsible for the different disorders. Paralleling the development of immunology in the 1970's was the accrual of knowledge about immunological events occurring during IM. These studies suggest that immune defense mechanisms deter mine the outcome of this viral infection rather than different viral strains. During the early 1970's, Starzl and Penn and Gatti and Good had noted an increased frequency of malignancy in renal allograft recipients and children with primary immune deficiency disorders, respectively. These observations provoked investigators to restudy the role of immune surveillance against malignancy. At that time immune surveillance was thought to occur against tumor-specific antigens; thereby neoplasms were eliminated.

Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

DOWNLOAD EBOOK →

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Mechanisms of Immunity to Virus-induced Tumors

Author: John W. Blasecki

Publisher:

Published: 1981

Total Pages: 376

ISBN-13:

DOWNLOAD EBOOK →

Contemporary Topics in Immunobiology

Author: Michael Hanna

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 299

ISBN-13: 1468430513

DOWNLOAD EBOOK →

It has long been suspected, and recently confirmed, that there is an etiologic relationship between several viruses and naturally occurring neoplasias. Virus precursors in the form of nucleic acids or antigens have consistently been associated with certain neoplasias. However, the role of these virus-specified precursors in etiology remains obscure. Recent studies of virus-associated neo plasias have led to advances in molecular techniques, which have yielded increas ingly sensitive assays for detection of virus-specific nucleic acids, and which have enabled the disruption of virus particles without concomitant loss in antigenicity of the components. These procedures have, in turn, resulted in molecular probes that allow more definitive evaluation of the host response to its virus and to the tumor cell with which the virus or its precursors are associated. Evaluations of the immune response and status of the host have provided important informa tion about carcinogenesis and the tools for seroepidemiological studies of a variety of cancers. These seroepidemiological studies have demonstrated that several human cancers, e. g. , Burkitt's lymphoma and nasopharyngeal carcinoma, are probably virus-induced, and that antibodies that are diagnostic and prog nostic for these diseases are detectable. The conclusion that feline leukemia is a disease transmitted horizontally by a virus resulted primarily from immunologi cal experiments.

AIDS-Associated Viral Oncogenesis

Author: Craig Meyers

Publisher: Springer Science & Business Media

Published: 2007-05-04

Total Pages: 274

ISBN-13: 0387468161

DOWNLOAD EBOOK →

One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.

Viral Immunology and Immunopathology

Author: Abner Louis Notkins

Publisher: Academic Press

Published: 2014-06-28

Total Pages: 496

ISBN-13: 148321897X

DOWNLOAD EBOOK →

Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

Malignant Transformation by Viruses

Author: Werner H. Kirsten

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 189

ISBN-13: 3642874029

DOWNLOAD EBOOK →

The position of "Cancer Teaching Coordinator" at The University of Chicago has been a consistently rewarding one because of the enthusiasm and support of the faculty and the students. This volume is the result of the second of two recent intensive teach ing sessions which have been planned and implemented by the group which forms the Cancer Coordinator's Advisory Committee. The first of these teaching sessions was held in early March of 1964 and was entitled "LEUKEMIA, A Current and Forward Look. " It attracted overflow attendance from the students and staff of this medical institution augmented by members of the other medical centers in Chicago. It was a stimulating and instructive colloquium, and the only regret we heard expressed afterward was that we had not arranged for publication of the many excellent presentations. One of the events commemorating the seventy-fifth anniversary of the founding of The University of Chicago was this symposium on malignant transformations. This time the Committee advised us to plan on speedy publication, and, logically, it chose Dr. Werner Kirsten, a member of our faculty and an active and effective investigator in this general field of endeavor, to serve as editor of the volume. Again, two of the same ingredients for effective instruction were blended: an excellent group of scientists presenting their latest work and a fine, attentive audience of students and staff.

Natural Resistance to Tumors and Viruses

Author: O. Haller

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 135

ISBN-13: 3642680690

DOWNLOAD EBOOK →

Natural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de fense in host resistance against both viruses and tumors. It is evi dent that considerable variation in the relative importance of di stinct mechanisms may be found among various resistance sy stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro priately complex effector mechanisms. Instances, however, whe re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media tor. The present volume provides insight into current concepts of such resistance mechanisms.