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Vibrational Spectroscopy in Diagnosis and Screening

Author: Feride Severcan

Publisher: IOS Press

Published: 2012

Total Pages: 432

ISBN-13: 1614990581

In recent years there has been a tremendous growth in the use of vibrational spectroscopic methods for diagnosis and screening. These applications range from diagnosis of disease states in humans, such as cancer, to rapid identification and screening of microorganisms. The growth in such types of studies has been possible thanks to advances in instrumentation and associated computational and mathematical tools for data processing and analysis. This volume of Advances in Biomedical Spectroscopy contains chapters from leading experts who discuss the latest advances in the application of Fourier transform infrared (FTIR), Near infrared (NIR), Terahertz and Raman spectroscopy for diagnosis and screening in fields ranging from medicine, dentistry, forensics and aquatic science. Many of the chapters provide information on sample preparation, data acquisition and data interpretation that would be particularly valuable for new users of these techniques including established scientists and graduate students in both academia and industry.

Vibrational Spectroscopy for Medical Diagnosis

Author: Max Diem

Publisher: Wiley

Published: 2008-05-05

Total Pages: 358

ISBN-13: 9780470012147

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Cancer is the second largest cause of death (after heart disease) in North America and Europe. Statistics from many countries serve constantly to inform us of how prevalent cancer is worldwide, even though one particular variation may be more predominant is one geographical region than another. The Traumatic cost in human lives, the dramatic cost of treatment and the need for rapidly advancing diagnoses and improving diagnostic methods for cancer, are clear for all to see. Current histopathological techniques for the detection and classification of cancer often lead to ambiguous diagnoses. Infrared and Raman spectroscopy have the potential to provide fast, accurate complementary techniques for the detection of many different forms of cancer. This book contains ten state-of-the-art chapters on the application of these techniques to the detection and classification of prostate, lymphatic, cervical, head and neck, and esophageal cancers, as well as reports on the application of vibrational spectroscopy to the study of individual human cells, and the identification of micro-organisms and erythrocytes, which should be of importance to spectroscopists and medical professionals alike. This book provides an up-to-date account of the practical means, applications and potential of mid-infrared and Raman spectroscopy for the medical diagnosis of diseased tissue and cells. It will be of significant interest both to vibrational spectroscopists involved in developing technique for medical diagnosis, and to clinicians, histopathologists, medical practitioners and students working in the field, with whom the spectroscopists must work closely in multi-disciplinary teams.

Biomedical Vibrational Spectroscopy

Author: Peter Lasch

Publisher: John Wiley & Sons

Published: 2008-06-27

Total Pages: 403

ISBN-13: 0470283165

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This comprehensive overview of biomedical applications of vibrational spectroscopy focuses on methodologies that are most relevant to biodiagnostics. After a few introductory chapters that summarize the current status of the field, the reference covers current spectroscopic applications; new spectroscopic directions; and study design and the analysis of vibrational spectral fingerprints from complex biological and clinical samples . With chapters contributed by leading international experts, Biomedical Vibrational Spectroscopy is a core resource.

Vibrational Spectroscopy for Tissue Analysis

Author: Ihtesham ur Rehman

Publisher: CRC Press

Published: 2012-09-27

Total Pages: 358

ISBN-13: 1439836086

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A rapidly growing field, vibrational spectroscopy has found applications in industries including pharmaceutical manufacture, food and drug safety, and process monitoring on production lines. In particular, interest in clinical spectroscopy is rising rapidly as researchers recognize the potential of the vibrational spectroscopic techniques—Infrared (IR) and Raman Spectroscopy—as noninvasive tissue diagnosis tools. However, the details of the characteristic peak frequencies and their relationship to specific functional groups present in the biological tissues have not been fully understood. Vibrational Spectroscopy for Tissue Analysis introduces IR and Raman Spectroscopy to those scientists who are either using these spectroscopic techniques to address clinical problems or planning to use spectroscopy to analyze clinical tissues and understand their chemical composition. By compiling the interpretations and understandings of the spectral peaks of the biological molecules in one place, this book aids in the understanding of IR and Raman Spectroscopy, and what these techniques can offer both in early diagnosis of the disease and monitoring of the progression of the disease. Despite the tremendous advances in the field of spectroscopy, where new applications are emerging at the pace of development, there are still areas of research that are crying for further exploration. This book bridges the gap between the spectroscopic research and medical applications.

Modern Vibrational Spectroscopy and Micro-Spectroscopy

Author: Max Diem

Publisher: John Wiley & Sons

Published: 2015-06-30

Total Pages: 432

ISBN-13: 1118824954

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Modern Vibrational Spectroscopy and Micro-Spectroscopy: Theory, Instrumentation and Biomedical Applications unites the theory and background of conventional vibrational spectroscopy with the principles of microspectroscopy. It starts with basic theory as it applies to small molecules and then expands it to include the large biomolecules which are the main topic of the book with an emphasis on practical experiments, results analysis and medical and diagnostic applications. This book is unique in that it addresses both the parent spectroscopy and the microspectroscopic aspects in one volume. Part I covers the basic theory, principles and instrumentation of classical vibrational, infrared and Raman spectroscopy. It is aimed at researchers with a background in chemistry and physics, and is presented at the level suitable for first year graduate students. The latter half of Part I is devoted to more novel subjects in vibrational spectroscopy, such as resonance and non-linear Raman effects, vibrational optical activity, time resolved spectroscopy and computational methods. Thus, Part 1 represents a short course into modern vibrational spectroscopy. Part II is devoted in its entirety to applications of vibrational spectroscopic techniques to biophysical and bio-structural research, and the more recent extension of vibrational spectroscopy to microscopic data acquisition. Vibrational microscopy (or microspectroscopy) has opened entirely new avenues toward applications in the biomedical sciences, and has created new research fields collectively referred to as Spectral Cytopathology (SCP) and Spectral Histopathology (SHP). In order to fully exploit the information contained in the micro-spectral datasets, methods of multivariate analysis need to be employed. These methods, along with representative results of both SCP and SHP are presented and discussed in detail in Part II.

Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences

Author: Andrei A. Bunaciu

Publisher: Elsevier

Published: 2020-07-26

Total Pages: 266

ISBN-13: 0128188286

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Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences synthesizes the latest research on the applications of vibrational spectroscopy in biomedical, pharmaceutical and food analysis. Suitable for graduate-level students as well as experienced researchers in academia and industry, this book is organized into five distinct sections. The first deals with the fundamentals of vibrational spectroscopy, with the second presenting the most important sampling methodology used for infrared and Raman spectroscopy in various fields of interest. Since spectroscopy is the study of the interaction of electromagnetic radiation with matter, this section deals with the characteristics, properties and absorption of electromagnetic radiation. Final sections describe the analytical studies performed all over the world in biomedical, pharmaceutical and in the food sciences. Presents a critical discussion of many of the applications of vibrational spectroscopy Covers details of the analytical methodologies used in pharmaceutical and biomedical applications Discusses the latest developments in pharmaceutical and biomedical analysis of both small and large molecules