Understanding Pancreatic Cancer: Current Trends - ECAB

Understanding Pancreatic Cancer: Current Trends - ECAB PDF

Author: Markus W Büchler

Publisher: Elsevier Health Sciences

Published: 2012-06-15

Total Pages: 140

ISBN-13: 8131232441

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Pancreatic cancer remains a dismal disease with an incidence that is on the rise even in a low incidence region like India. In recent years, there have been significant advances in the understanding of pancreatic cancer largely due to strides in modern molecular biology, pathology and radiology. While molecular biology continues to provide an optimistic vision for future treatment approaches to this deadly disease, the recent identification of PanIN’s and resection margins in pancreatic cancer have important implications for current day-to-day practice. This book explains how better understanding of IPMN and its management has improved the scope of pancreatic tumors. It also explains what role do heat shock proteins perform in cancer. The book gives concise description on how a number of important advances have made pancreatic pathology an exciting and rapidly advancing field. There are chapters that explain how good endoscopic ultrasound is in detection of cancer pancreas and also talk about experimental studies on obstructive jaundice and biliary drainage. Neo-adjuvant strategies in operable pancreatic adenocarcinomas are also being explained in detail. It is sincerely hoped that this book will update the busy clinician as well as the academician on various aspects of current importance in management of pancreatic cancer. Understanding the role of IPMN in improving the scope of pancreatic tumors Describing performance of heat shock proteins in cancer Throwing some light on usefulness of endoscopic ultrasound in detecting cancer pancreas Getting an insight into neo-adjuvant strategies in operable pancreatic adenocarcinomas

Acute Cholecystitis

Acute Cholecystitis PDF

Author: Soumitra R. Eachempati

Publisher: Springer

Published: 2015-08-20

Total Pages: 231

ISBN-13: 3319148249

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This text covers all aspects of the current diagnosis and treatment of acute cholecystitis. Different diagnostic tests are discussed as well as the preoperative evaluation needed to initiate treatment. Other sections include the management of acute cholecystitis in the critically ill and elderly patients, recent advances in operative strategies that have further altered the treatment of acute cholecystitis, and the utilization of routine intraoperative cholangiography and its relative merits. Primarily intended for general surgeons and residents training in general surgery, Acute Cholecystitis will also serve as a comprehensive reference material for other health care providers, including primary care providers, mid-level nurse practitioners, emergency room physicians and medical students.

Dilemmas in Abdominal Surgery

Dilemmas in Abdominal Surgery PDF

Author: Savio George Alberto da Piedade Barreto

Publisher: CRC Press

Published: 2020-11-12

Total Pages: 331

ISBN-13: 0429534035

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This book covers the management of surgical diseases "through the eyes" of a clinician by providing an evidence-based approach to specific clinical dilemmas. The chapters take the reader through a step-by-step "decision-making" approach to commonly encountered, but difficult to manage, situations where the editors share their rationale behind the process. Emphasis is placed on the use of tables and algorithms to simplify understanding. They aim to empower the readers with the ability to manage complex abdominal surgery scenarios in a streamlined manner, thus improving the care and outcome of patients. Key Features Targets specific, difficult to manage scenarios Provides expert opinion/advice on how to tackle tricky situations Covers both benign and malignant cases Examines surgical dilemmas through illustrations

Modern GI Oncology - E-Book

Modern GI Oncology - E-Book PDF

Author: Shailesh V Shrikhande

Publisher: Elsevier Health Sciences

Published: 2015-08-31

Total Pages: 530

ISBN-13: 8131236838

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Modern Gastrointestinal Oncology is a comprehensive and authoritative book dealing with contemporary issues in diagnosis and management of gastrointestinal cancers. The book is specially designed to update senior students, super-specialty residents, fellows and all clinicians with an interest in gastrointestinal cancers. Interdisciplinary coverage of gastrointestinal cancer by more than 70 authors who are leading epidemiologists, researchers, gastroenterologists, surgeons, medical oncologists and radiation oncologists from all over the world Special emphasis on controversial issues in management of gastrointestinal cancers Dynamic and in-depth information coupled with practical guidelines to aid the busy clinician Lucid presentation with texts, figures, updated case studies and key research questions

Anti-aging Drugs

Anti-aging Drugs PDF

Author: Alexander M Vaiserman

Publisher: Royal Society of Chemistry

Published: 2017-02-01

Total Pages: 592

ISBN-13: 178262435X

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Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Epigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders PDF

Author: Nagy Youssef

Publisher: Academic Press

Published: 2022-02-18

Total Pages: 422

ISBN-13: 0128230622

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Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or “epidrugs. Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field

Advances in Inflammatory Bowel Diseases

Advances in Inflammatory Bowel Diseases PDF

Author: P. Rutgeerts

Publisher: Springer Science & Business Media

Published: 1998-12-31

Total Pages: 340

ISBN-13: 9780792387503

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Ulcerative colitis and Crohn's disease remain a great therapeutic challenge to the medical community. In recent years knowledge about the pathogenesis of these diseases has progressed rapidly but the cause of the diseases remains completely unknown. It has become clear that dysregulation of the mucosal immune system is the basis for the chronic evolution of the diseases in a genetically susceptible population. Exciting new therapeutic approaches have been attempted in the last couple of years and cytokine and anti-cytokine treatments in particular seem very promising, especially in intractable disease. The format of the Falk Symposium 106 on `Advances in Inflammatory Bowel Diseases', held in Brussels, Belgium, June 18-20, 1998, was somewhat innovative as each session attempted to link the new insights into pathogenetic mechanisms with new therapeutic approaches, resulting in optimal information transfer. The classic therapeutic schemes were updated with a special focus on step-wise build-up of therapy.

Progress in Medical Research

Progress in Medical Research PDF

Author: Mieczyslaw Pokorski

Publisher: Springer

Published: 2018-08-21

Total Pages: 118

ISBN-13: 3319896652

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This book is a compendium of articles providing insights into a range of contemporary ideas concerning the core yet unsettled clinical issues. Important aspects of pulmonary disorders are tackled such as occupational respiratory health hazards, asthma, or the role of vitamin D in obstructive airway diseases. Genotyping offers a clear promise in the diagnostics of chronic pulmonary lesions of autoimmune background. Cardiac and respiratory-driven pulsation of cerebrospinal fluid content offers novel arguments in the pathophysiologic savvy of a range of brain dysfunctional conditions, including respiratory-related hypoxic pathologies. Some other articles tackle the heady topics of rehabilitation medicine, offering an insight into research-underpinned diagnostics and practical management solutions in a range of musculoskeletal disorders and injuries that affect the human body's movement, particularly those controlled by the autonomic nervous system. The book is addressed to clinicians, researchers, physiotherapists, and medical professionals engaged in patient care.

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