Trophoblast Invasion and Endometrial Receptivity

Trophoblast Invasion and Endometrial Receptivity PDF

Author: H.W. Denker

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 455

ISBN-13: 1461306159

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Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, older data can be reevaluated in the light of current research into cell cell and cell-matrix interactions. The feeling that new avenues of research are open was apparent when an international group of scientists came together at a workshop on "The Cell Biology of Trophoblast Invasion In Vivo and In Vitro" held during the XXIV Annual Meeting of the Cell, Tissue and Organ Culture Study Group (C.T.O.C.) at Heidelberg in 1986. What was unusual about this Conference was the interdisciplinary dialogue between implantation researchers and tumor biologists, highlighting aspects common to invasion of trophoblast and tumor cells.

Molecular and Cellular Aspects of Periimplantation Processes

Molecular and Cellular Aspects of Periimplantation Processes PDF

Author: S.K. Dey

Publisher: Springer

Published: 1995-12-22

Total Pages: 392

ISBN-13:

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This volume contains the proceedings of the Symposium on Molecular and Cellular Aspects of Periimplantation Processes, held July 15 - 18, 1994, in Boston, Massachusetts. Despite considerable research, the molecular and cellular bases of embryo-uterine interactions are still poorly understood. The papers included in this volume address recent advances in several areas in the field of implantation, including uterine receptivity, hormonal regulation, cell-cell interaction, growth factors/cytokines, immunobiology, and trophoblast invasion.

Endocrinology of Embryo—Endometrium Interactions

Endocrinology of Embryo—Endometrium Interactions PDF

Author: Stanley R. Glasser

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 413

ISBN-13: 1461518814

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Early embryonic loss is a continuing social and economic global problem. In human populations the estimates of interruptions early in pregnancy range from 35-60%. In animal husbandry (swine, ruminants) fully 30% of pregnancies fail to survive early events of gestation. The futility associated with this persistant high risk is even more unsettling because of advances made in assisted reproductive technology which, although this very selective methodology has added to our knowledge of embryo-endometrial interactions, has resulted in a birth rate of only 14%. These studies have instigated comparisons of the live relative contributions of the embryo and the uterus to the outcome of pregnancy. These analyses have shown that we have learned significantly less about the role of the uterus in deciding the outcome of either natural or assisted pregnancies. In 1979 a quotation by George Corner was used to set the tone of a meeting that was devoted to discussion of the cellular and molecular aspects of implantation. In spite of the proliferation in research activity which occurred in the following 15 years our real understanding of the embryo transfer process has fallen short of our expectations. We use the Corner quotation, once again, to preface this symposium so that we may recall that the fundamental nature of the process which regulates embryo-endometrial interactions still escapes us.

Endometrium and Embryo Implantation

Endometrium and Embryo Implantation PDF

Author: G. Chaouat

Publisher:

Published: 2007

Total Pages: 0

ISBN-13: 9783805582810

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Implantation of the embryo into the maternal endometrium represents a crucial step in the reproductive process. It results from a cascade of finely tuned events. Despite recent progress in the field, many points still require clarification. This special issue offers a broad coverage of the latest findings. New concepts and applications are presented which are based on data strongly suggesting that both embryo implantation and uterine receptivity are controlled, primarily, though not exclusively, by locally acting growth factors and cytokines. Different processes are also studied, such as the MMPs expression regulating the trophoblast invasion, or the possible secretion of sHLA-G molecules by human embryos and its correlation to a successful pregnancy. Further points under discussion are the chromosomal imbalance leading to embryonic mortality, and the potential of the baboon model to study embryo implantation. Finally, a comparative survey is given of the general mechanical, endocrinological and cellular aspects involved in implantation in mammals. Clinicians as well as basic researchers will find this special issue to be a valuable source of new insights.

Uterine Endometrial Function

Uterine Endometrial Function PDF

Author: Hideharu Kanzaki

Publisher: Springer

Published: 2016-05-26

Total Pages: 155

ISBN-13: 4431559728

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This book focuses on uterine endometrial function and receptivity from multiple perspectives. The chapters cover a variety of topics including the role of estrogen and progesterone, animal models, parameters for assessing endometrial receptivity, the mechanism of angiogenesis, epigenetic regulation, and stem/progenitor cells. Despite nearly 35 years of experience with in vitro fertilization, the rate of successful implantations remains low. Abnormal endometrial receptivity has been proposed as one of the factors contributing to reduced reproductive potential in women, but our understanding of it is limited. Endometrial receptivity results from an orchestrated interplay between the embryo and the maternal endometrium, and the receptive status, known as the window of implantation, is reached only briefly in the mid-luteal phase. This book provides a comprehensive overview of the latest advances in endometrial function and paves the way for innovative treatments and drug development for infertility. This work will appeal to a wide readership, from researchers on endometrial function and assisted reproductive technology (ART) to clinicians and technicians in the field of gynecology.

The Human Endometrium

The Human Endometrium PDF

Author: Carlo Bulletti

Publisher:

Published: 1994

Total Pages: 522

ISBN-13:

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The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.

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