Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals

Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals PDF

Author: P.L. Chambers

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 407

ISBN-13: 3642690831

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Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980).

Breeding for Enhanced Nutrition and Bio-Active Compounds in Food Legumes

Breeding for Enhanced Nutrition and Bio-Active Compounds in Food Legumes PDF

Author: Debjyoti Sen Gupta

Publisher: Springer Nature

Published: 2021-01-18

Total Pages: 269

ISBN-13: 3030592154

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More than 20 million childhood deaths occur every year due to the micronutrient deficiency and diet-related non-communicable diseases (cardiovascular diseases, cancers, chronic respiratory diseases and diabetes). The United Nations (UN) recently announced that the increase in chronic, non-communicable diseases has resulted in 36 million deaths around the world annually, claiming more lives than all other causes combined. These chronic diseases are not isolated to developed countries and are even more pronounced in the developing world. Such chronic illnesses have caused far more deaths than infectious diseases throughout the world (except Africa) in recent years. Therefore, enrichment of micronutrients in staple food crops is of paramount importance for the nutritional security in our world. Biofortification is the development of micronutrient- and/or vitamin-rich crops using traditional crop improvement practices as well as modern biotechnology tools. It is a more sustainable and cost effective method than food supplementation, fortification and diet diversification. This work consolidates available information on the different aspects of breeding for improved nutrition of pulses. An overview of entire pulses based on their nutritional profile is given so that audience can find the desired information easily. Food legumes are the active ingredients in many gluten-free food products and there is a continuous rise of the use of pulses flour in milling and baking processes. Our book sheds light on recent efforts and the underlying constraints of meeting the public demand. We believe this work provides the basic information for anyone interested in biofortification and stimulate further research to meet this unique challenge.

Current Catalog

Current Catalog PDF

Author: National Library of Medicine (U.S.)

Publisher:

Published:

Total Pages: 1712

ISBN-13:

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First multi-year cumulation covers six years: 1965-70.

Advances in Food and Nutrition Research

Advances in Food and Nutrition Research PDF

Author:

Publisher: Academic Press

Published: 2009-10-26

Total Pages: 269

ISBN-13: 0080922376

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Advances in Food and Nutrition Research recognizes the integral relationship between the food and nutritional sciences and brings together outstanding and comprehensive reviews that highlight this relationship. Contributions detail scientific developments in the broad areas of food science and nutrition and are intended to provide those in academia and industry with the latest information on emerging research in these constantly evolving sciences. *The latest important information for food scientists and nutritionists *Peer-reviewed articles by a panel of respected scientists *The go-to series since 1948

Genomic Designing of Climate-Smart Pulse Crops

Genomic Designing of Climate-Smart Pulse Crops PDF

Author: Chittaranjan Kole

Publisher: Springer

Published: 2019-05-28

Total Pages: 469

ISBN-13: 3319969323

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This book describes the concepts, strategies and techniques for pulse-crop improvement in the era of climate change, highlighting the latest advances in plant molecular mapping and genome sequencing. Genetic mapping of genes and QTLs has broadened the scope of marker-assisted breeding and map-based cloning in almost all major pulse crops. Genetic transformation, particularly using alien genes conferring resistance to herbicide, insects and diseases has facilitated the development of a huge number of genetically modified varieties of the major pulse crops. Since the genome sequencing of rice in 2002, genomes of over 7 pulse crops have been sequenced. This has resulted in the possibility of deciphering the exact nucleotide sequence and chromosomal positions of agroeconomic genes. Most importantly, comparative genomics and genotyping-by-sequencing has opened up a new vista for exploring wild crop relatives for identification of useful donor genes.

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