The Ultrastructure of Human Tumours

The Ultrastructure of Human Tumours PDF

Author: Brian Eyden

Publisher: Springer Science & Business Media

Published: 2014-02-12

Total Pages: 692

ISBN-13: 3642391680

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The Ultrastructure of Human Tumours: Applications in Diagnosis and Research describes the core features as seen by transmission electron microscopy, defining the different types of cellular differentiation in tumours; this is relevant for tumour nomenclature and diagnosis, which, in turn, are important for tumour pathologists in their collaboration with oncologists for the treatment of cancer patients. The book is divided into 8 chapters. Following an introduction on technique and procedure, there are chapters on epithelial tumours, melanocytic lesions, soft-tissue and related tumours, lymphoma and leukaemia, CNS neoplasms and neuroendocrine and neuronal tumours. Each chapter includes an introductory text that puts the ultrastructural features in the context of classical pathology. The book includes many new findings and interpretations from well-known tumours, as well as ultrastructural information on several newly described tumour entities not dealt with in existing tumour ultrastructure monographs. The book will especially be of value to tumour pathologists who need to solve problem cases with the aid of electron microscopy, but also to cancer research and tissue engineering scientists working to develop anti-cancer and stem-cell-based therapies. However, even those without access to electron microscopy may also benefit from this book, since many of the images provide an ‘explanation’ of the appearances of cells, tissues and tumours familiar to pathologists and scientists from light microscopy. In this respect, it is hoped that this book will stimulate the wider use of electron microscopy in pathology. The book is comprehensively referenced, 680 pages long and lavishly illustrated with 757 figures. Dr. Brian Eyden is Consultant Clinical Scientist and Dr. S. Sankar Banerjee Consultant Histopathologist in the Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK; Dr. Yongxin Ru is Director of the Department of Electron Microscopy, Institute of Hematology and Blood Diseases Hospital, Tianjin, China; Paweł Liberski is Professor in the Department of Molecular Pathology and Neuropathology, Medical University Łódź, Poland.

Ultrastructure of Human Sella Tumors

Ultrastructure of Human Sella Tumors PDF

Author: A.M. Landolt

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 252

ISBN-13: 3709184207

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This monograph on the "Ultrastructure of Human Sella Tumors" is in fact a study of the correlations of clinical findings and morphology. It is a timely and eagerly awaited publication because of the increasing interest of the endocrinologist in pituitary disorders and of the neuro surgeon in the newest aspects of surgery on pituitary tumors, and also because of the unsatisfactory but still widely accepted classification into eosinophil, basophil and chromophobe pituitary adenomas. This old classification has been mainly based on granule color as seen after hematoxylin-eosin staining, but it does not, after extensive clinical observations, reflect in many instances the type of clinical picture observed. The author has brilliantly succeeded in demonstrating in a convinc ing way, by an extensive study of the relevant literature and by his own histological work, that further insight into the biology of the hypophysis and of the pituitary tumor can be obtained only by newer methods of light microscopic staining, immuno-histochemistry and electron microscopy combined with radio-immunological blood hormone determination.

Tumours of the Nervous System

Tumours of the Nervous System PDF

Author: Timothy H. Moss

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 159

ISBN-13: 1447114264

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Since the time of the earliest electron microscopic studies on tumours of the human nervous system. undertaken over 20 years ago by Luse and her colleagues. there have been considerable advances in our understanding of these neoplasms. Tissue culture and specific antibodies to tumour antigens are two of the techniques which have greatly aided such advances. enabling much to be learned about the biological properties and underly ing nature of all types of nervous system tumour. Electron microscopy. however. has continued to prove of considerable value in the investigation of these tumours. and the technological advances of the last two decades have dramatically improved the resolution and overall quality of the ultrastructural images obtained. In clinical neuropathology. such improvements have encouraged a more widespread use of the electron microscope in the diagnosis of human nervous system tumours. alongside antibody techniques and more conventional histological methods. Although ultrastructural examination is often not strictly necessary to identify well-differentiated tumours such as astrocytomas or choroid plexus papillomas. study of the electron microscopic features in such cases fre quently proves useful in the diagnosis of their more malignant counterparts. Thus the recognition of astrocytic filaments in anaplastic gliomas. or of cilia in pleomorphic choroid plexus carcinomas. may enable a diagnosis to be made in cases where there is insufficient differentiation for the tumours to be recognised at light microscopic level.

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease PDF

Author: Thomas Seyfried

Publisher: John Wiley & Sons

Published: 2012-05-18

Total Pages: 482

ISBN-13: 1118310306

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The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Mitochondrial Medicine

Mitochondrial Medicine PDF

Author: Volkmar Weissig

Publisher:

Published: 2021

Total Pages: 468

ISBN-13: 9781071612705

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This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Human Tumor Cells in Vitro

Human Tumor Cells in Vitro PDF

Author: Jorgen Fogh

Publisher: Springer

Published: 2012-11-25

Total Pages: 557

ISBN-13: 9781475716498

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The study of cultured human tumor cells is a most obvious approach in experimental human cancer research. For many techniques in virology, immunology, biochemistry, and biophysics, for example, large amounts of cells may be required and such quantities are usually provided only when the cultures develop into established cell lines; when this happens, thorough characterization also becomes possible. The development of cell lines, therefore, is of prime importance. Recent major advances in research with animal cell systems see m to be a prologue for present and future efforts directed toward work with human tumor cells in culture. Conceivably, the most significant results in cancer research may develop from work with such cells, and so the time seemed right to define the present state of our knowledge. This is the first book dedicated exclusively to the subject: human tumor cells in vitro. Although so me of the fundamental aspects in the cultivation of human tumor ceIls, and the extent to which they represent human cancer in vivo are still unclear, I asked a number of the leading investigators in this area of research to collect and evaluate previous and present contributions, and to offer their thoughts on the questions to which answers are not yet available. Many of the chapters are concerned with techniques of cultivation. Cultures from some types of tumors have grown weIl; in many cases they have given rise to established cell lines.

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