The role of monocytes/macrophages in autoimmunity and autoinflammation
Author: Atsushi Kawakami
Publisher: Frontiers Media SA
Published: 2022-12-22
Total Pages: 222
ISBN-13: 2832509487
DOWNLOAD EBOOK →Lanterna Rally
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Macrophage Activation
Author: Khalid Hussain Bhat
Publisher: BoD – Books on Demand
Published: 2020-03-25
Total Pages: 134
ISBN-13: 1789846447
DOWNLOAD EBOOK →Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Monocyte Heterogeneity and Function
Author: Pierre Guermonprez
Publisher: Frontiers Media SA
Published: 2021-02-11
Total Pages: 205
ISBN-13: 2889664775
DOWNLOAD EBOOK →Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity
Author: Changjun Yin
Publisher: Frontiers Media SA
Published: 2017-05-22
Total Pages: 237
ISBN-13: 2889451801
DOWNLOAD EBOOK →The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
Textbook of Autoinflammation
Author: Philip J. Hashkes
Publisher: Springer
Published: 2019-02-13
Total Pages: 820
ISBN-13: 3319986058
DOWNLOAD EBOOK →This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
Oxford Textbook of Rheumatology
Author: Philip Conaghan
Publisher: Oxford University Press
Published: 2013-10
Total Pages: 1553
ISBN-13: 0199642486
DOWNLOAD EBOOK →A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Innate Immunity and Inflammation
Author: Ruslan Medzhitov
Publisher: Cold Spring Harbor Perspective
Published: 2015
Total Pages: 0
ISBN-13: 9781621820291
DOWNLOAD EBOOK →"A subject collection from Cold Spring Harbor perspectives in biology."
Inflammasomes: Clinical and Therapeutic Implications
Author: Mario D. Cordero
Publisher: Springer
Published: 2018-09-04
Total Pages: 400
ISBN-13: 3319893904
DOWNLOAD EBOOK →The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Inflammation, 4 Volume Set
Author: Jean-Marc Cavaillon
Publisher: John Wiley & Sons
Published: 2018-02-20
Total Pages: 1818
ISBN-13: 3527338993
DOWNLOAD EBOOK →The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.
Autophagy, Infection, and the Immune Response
Author: William T. Jackson
Publisher: John Wiley & Sons
Published: 2015-02-16
Total Pages: 364
ISBN-13: 1118677641
DOWNLOAD EBOOK →The relationship between infection and immunity and autophagy, a pathway of cellular homeostasis and stress response, has been a rapidly growing field of study over the last decade. While some cellular processes are pro- or anti-infection, autophagy has been proven to be both: a part of the innate immune response against some microbes, and a cellular pathway subverted by some pathogens to promote their own replication. Autophagy, Infection, and the Immune Response provides a unified overview of the roles of cellular autophagy during microbial infection. Introductory chapters ground the reader by delineating the autophagic pathway from a cellular perspective, and by listing assays available for measuring autophagy. Subsequent chapters address virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma. Designed as a resource for those interested in initiating studies on the relationship between autophagy and infection or immunity, Autophagy, Infection, and the Immune Response combines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.
