Diet-Microbe Interactions in the Gut

Diet-Microbe Interactions in the Gut PDF

Author: Kieran Tuohy

Publisher: Academic Press

Published: 2014-08-04

Total Pages: 268

ISBN-13: 0124079415

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Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens

Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens PDF

Author: Sudhanshu Shekhar

Publisher: Frontiers Media SA

Published: 2020-01-14

Total Pages: 195

ISBN-13: 2889633365

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Trillions of commensal microbes reside on and inside the human body, including the intestinal and respiratory tracts, which encompass various microbial taxa, such as bacteria, fungi, archea and viruses. The close proximity of microbes with the host provides an opportunity to continually interact with each other. Advances in research approaches, including high-throughput sequencing, have allowed us to study host and commensal microbes at the genetic and functional levels. Recent studies suggest that commensal microbes play a crucial role in the development of the host’s immune system and induce innate and adaptive immune responses against pathogens. It is also becoming apparent that the gut commensals are endowed with a capacity to alter immune responses in organs beyond the intestine, such as the lungs, highlighting the significance of the gut commensals in controlling systemic immunity. On the other hand, the host’s immune system possesses the ability to shape the repertoire of commensal microbes and contribute to the establishment of beneficial relationships with them. A better understanding of host-commensal interactions will be important for designing effective vaccines and therapeutics against pathogens. This Research Topic sheds light on our current understanding of the interplay between the host’s immune system and commensal microbes and how this interplay can be exploited for prophylactic and/or therapeutic strategies against pathogens.

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases PDF

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2019-01-26

Total Pages: 628

ISBN-13: 0128138211

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Bioactive Food as Dietary Interventions for Arthritis and Inflammatory Diseases, Second Edition is a valuable scientific resource that focuses on the latest advances in bioactive food research and the potential benefit of bioactive food choice on arthritis. Written by experts from around the world, the book presents important information that can help improve the health of those at risk for arthritis and related conditions using food selection as its foundation. Serves as a starting point for in-depth discussions in academic settings Offers detailed, well-documented reviews outlining the ability of bioactive foods to improve and treat arthritis Includes updated research on the global epidemic of diabetes Updated with current research on antioxidant flavonoids, anti-Inflammatory natural foods, ginger and the effects of beef on inflammation Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathways

Probiotics and Prebiotics in Food, Nutrition and Health

Probiotics and Prebiotics in Food, Nutrition and Health PDF

Author: Semih Otles

Publisher: CRC Press

Published: 2013-12-09

Total Pages: 510

ISBN-13: 1466586249

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Presenting the work of international experts who discuss all aspects of probiotics and prebiotics, this volume reviews current scientific understanding and research being conducted in this area. The book examines the sources and production of probiotics and prebiotics. It explores their use in gastrointestinal disorders, infections, cancer preventi

Gut Microbiota

Gut Microbiota PDF

Author: Edward Ishiguro

Publisher: Elsevier

Published: 2023-06-22

Total Pages: 282

ISBN-13: 032391389X

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Building off the success of the first edition, Gut Microbiota: Interactive Effects on Nutrition and Health, Second Edition, details the complex relationship between diet, the gut microbiota, and health. This second edition expands its coverage of emerging practical applications in nutrition and medicine. Covering topics such as the ecological concepts that apply to the gut microbiota and the effects of aging on the gut microbiome, among others, this book is sure to be a welcome resource to microbiome science trainees, food and nutrition researchers working in academia, and industry and healthcare professionals giving dietary recommendations to the general public. Presents diet, the gut microbiota, and health in a way that helps the reader interpret the value of related consumer tests and products Includes frequently asked questions that help clinicians provide succinct answers to their patients or clients Covers gut microbiota in the context of nutrition research and analyzes gaps in current knowledge to shape the design of future studies in this field

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book PDF

Author: John E. Bennett

Publisher: Elsevier Health Sciences

Published: 2019-08-08

Total Pages: 5208

ISBN-13: 0323550274

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For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips. Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource. Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis. Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases. Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases. Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci. PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America. Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition.

Environmental Chemicals, the Human Microbiome, and Health Risk

Environmental Chemicals, the Human Microbiome, and Health Risk PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2018-03-01

Total Pages: 123

ISBN-13: 0309468698

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A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.