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Functional Ultrastructure

Author: Margit Pavelka

Publisher: Springer Science & Business Media

Published: 2010-07-16

Total Pages: 366

ISBN-13: 3211993908

The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.

The Nuclear Envelope

Author: David Evans

Publisher: Garland Science

Published: 2004-09-01

Total Pages: 320

ISBN-13: 0203643399

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The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

The Nuclear Envelope: Methods and Protocols

Author: Sue Shackleton

Publisher: Methods in Molecular Biology

Published: 2018-05-19

Total Pages: 540

ISBN-13: 9781493980680

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This volume provides a wide range of protocols used in studying the nuclear envelope, with special attention to the experimental adjustments that may be required to successfully investigate this complex organelle in cells from various organisms. The Nuclear Envelope: Methods and Protocols is divided into five sections: Part I - Nuclear Envelope Isolation; Part II - Nuclear Envelope Protein Interactions, Localization, and Dynamics; Part III - Nuclear Envelope Interactions with the Cytoskeleton; Part IV - Nuclear Envelope-Chromatin Interactions; and Part V - Nucleo-Cytoplasmic Transport. Many of the modifications discussed in this book have only been circulated within laboratories that have conducted research in this field for many years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, The Nuclear Envelope: Methods and Protocols is a timely resource for researchers who have joined this dynamic and rapidly growing field.

The Cell: A Very Short Introduction

Author: Terence Allen

Publisher: OUP Oxford

Published: 2011-09-29

Total Pages: 160

ISBN-13: 0191620262

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All living things on Earth are composed of cells. A cell is the simplest unit of a self-contained living organism, and the vast majority of life on Earth consists of single-celled microbes, mostly bacteria. These consist of a simple 'prokaryotic' cell, with no nucleus. The bodies of more complex plants and animals consist of billions of 'eukaryotic' cells, of varying kinds, adapted to fill different roles - red blood cells, muscle cells, branched neurons. Each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years or so through modern techniques of microscopy, biochemistry, and molecular biology. In this Very Short Introduction, Terence Allen and Graham Cowling describe the nature of cells - their basic structure, their varying forms, their division, their differentiation from initially highly flexible stem cells, their signalling, and programmed death. Cells are the basic constituent of life, and understanding cells and how they work is central to all biology and medicine. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Principles of Biology

Author: Lisa Bartee

Publisher:

Published: 2017

Total Pages:

ISBN-13: 9781636350417

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The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.

Compendium of Histology

Author: Anders Rehfeld

Publisher: Springer

Published: 2017-09-07

Total Pages: 670

ISBN-13: 3319418734

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This book has been designed to help medical students succeed with their histology classes, while using less time on studying the curriculum. The book can both be used on its own or as a supplement to the classical full-curriculum textbooks normally used by the students for their histology classes. Covering the same curriculum as the classical textbooks, from basic tissue histology to the histology of specific organs, this book is formatted and organized in a much simpler and intuitive way. Almost all text is formatted in bullets or put into structured tables. This makes it quick and easy to digest, helping the student get a good overview of the curriculum. It is easy to locate specific information in the text, such as the size of cellular structures etc. Additionally, each chapter includes simplified illustrations of various histological features. The aim of the book is to be used to quickly brush up on the curriculum, e.g. before a class or an exam. Additionally, the book includes guides to distinguish between the different histological tissues and organs that can be presented to students microscopically, e.g. during a histology spot test. This guide lists the specific characteristics of the different histological specimens and also describes how to distinguish a specimen from other similar specimens. For each histological specimen, a simplified drawing and a photomicrograph of the specimen, is presented to help the student recognize the important characteristics in the microscope. Lastly, the book contains multiple “memo boxes” in which parts of the curriculum are presented as easy-to-remember mnemonics.

The Nucleus, Second Edition

Author: Ana Pombo

Publisher:

Published: 2021-09

Total Pages: 300

ISBN-13: 9781621823896

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The nucleus is the most prominent structure in eukaryotic cells. It houses the cell's DNA and is the hub for DNA replication, transcription, and RNA processing. Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time--and the implications of that organization for proper function--has lagged behind that of other cellular structures. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included. Multiple chapters are devoted to physiological and disease processes involving disruption of nuclear structure and function (e.g., viral infection). This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease.

The Nuclear Envelope and the Nuclear Matrix

Author: Wistar Institute of Anatomy and Biology

Publisher:

Published: 1982

Total Pages: 344

ISBN-13:

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The Nuclear Envelope in Freeze-Etching

Author: J. Kartenbeck

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 55

ISBN-13: 3662103907

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During the past twenty years the structure of the nuclear envelope, and in particular, that of its most distinct elements, the nuclear pore complexes, has been described from thin section electron microscopy (e, g., Brettschneider, 1952; Hartmann, 1953; Bahr and Beermann, 1954; Watson, 1954; Kautz and de Marsh, 1955; Watson, 1955), from metal-shadowed (e. g., Callan and Tomlin, 1950; Gall, 1954, 1956) and negatively stained (e. g., Franke, 1966, 1967; Gall, 1967; Yoo and Bayley, 1967) preparations of isolated nuclear membranes as revealing characte ristics common to euka. ryotic cells in general (recently reviewed, e. g., in Gouran ton, 1969; Stevens and Andre, 1969; Franke, 1970). In the recent years the freeze-etch technique (Steere, 1957) has proved to be a particularly useful tool in studying membraneous structures (e. g., Moor and Miihlethaler, 1963; Branton and Moor, 1964; Branton, 1966; Koehler, 1968b; Staehelin, l968a; Northcote, 1968a; Branton, 1969; Moor, 1969a). So this method has especially broadened the knowledge, e. g., on bacterial membranes (Bayer and Remsen, 1970; Nanninga, 1970), on erythrocyte plasma membranes (Weinstein and Bullivant, 1967; Meyer and Winkelmann, 1970; da Silva and Branton, 1970; Tillack and Marchesi, 1970), on liver cell membranes (Chalcroft and Bullivant, 1970), on Golgi membranes (Werz and Kellner, 1970; Staehelin and Kiermayer, 1970), on synaptic vesicles (Moor et al.

Concepts of Biology

Author: Samantha Fowler

Publisher:

Published: 2018-01-07

Total Pages: 618

ISBN-13: 9789888407453

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Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.