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Diagnosis and Treatment of Spinal Cord Injury

Author: Rajkumar Rajendram

Publisher: Academic Press

Published: 2022-05-10

Total Pages: 628

ISBN-13: 0128224991

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The Neuroscience of Spinal Cord Injury-

Author: Rajkumar Rajendram

Publisher: Academic Press

Published: 2022-05-27

Total Pages: 1186

ISBN-13: 0323995764

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Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Diagnosis and Treatment of Spinal Cord Injury: Covers both the diagnosis and treatment of spinal cord injury Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on epidemiology and pain Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury: Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal events Includes plasticity and gene expression Examines health and stress behaviors after spinal cord injury

Spinal Cord Injury

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2005-08-27

Total Pages: 361

ISBN-13: 0309095859

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An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.

Neurobiology of Spinal Cord Injury

Author: Robert G. Kalb

Publisher: Springer Science & Business Media

Published: 1999-10-22

Total Pages: 293

ISBN-13: 1592592007

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Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Neurological Aspects of Spinal Cord Injury

Author: Norbert Weidner

Publisher: Springer

Published: 2018-06-12

Total Pages: 0

ISBN-13: 9783319834863

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This clinically focused book aims to cover for the first time all of the neurological aspects relevant to the diagnosis and treatment of spinal cord disease. Furthermore, innovative neurorestorative therapeutic strategies - aiming for repair of the damaged spinal cord and/or reorganization of the remaining nervous system - with significant potential for translation into clinical routine are presented. The book covers a comprehensive list of topics, including epidemiology, neuroanatomy, etiology of compressive and non-compressive spinal cord injury, imaging, neurophysiology, neurological sequelae, and complications with emphasis on dysfunction of the autonomic nervous system. Both clinically established and preclinical therapies are discussed in detail. The book is suited for trainees and practicing clinicians including neurologists, spine surgeons, rehabilitation specialists, neuroradiologists, and occupational/physical therapists; it will also be of value to neuroscientists involved in research into spinal cord disease.

Restorative Neurology of Spinal Cord Injury

Author: Milan R. Dimitrijevic

Publisher: OUP USA

Published: 2012-01-12

Total Pages: 337

ISBN-13: 0199746508

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Following injury or disease, neural circuitry can be altered to varying degrees leading to highly individualized characteristics that may or may not resemble original function. In addition, lost or partially damaged circuits and the effects of biological recovery processes coupled with learned compensatory strategies create a new neuroanatomy with capabilities that are often not functional or may interfere with daily life. To date, the majority of approaches used to treat neurological dysfunction have focused on the replacement of lost or damaged function, usually through the suppression of surviving neural activity and the application of mechanical assistive devices. Restorative Neurology of Spinal Cord Injury offers a different and novel approach. Focusing on the spinal cord and its role in motor control, the book details the clinical and neurophysiological assessment process and methods developed throughout the past half century by basic and clinical scientists. Then, through the use of specialized clinical and neurophysiological testing methods, conduction and processing performed within the surviving neural circuitry is examined and characterized in detail. Based on the results of such assessment, treatment strategies, also described in this book, are applied to augment, rather than replace, the performance of surviving neural circuitry and improve the functional capacity of people who have experienced injury to their spinal cords.

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury

Author: Rajkumar Rajendram

Publisher: Academic Press

Published: 2022-05-10

Total Pages: 558

ISBN-13: 0128224282

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Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal events Includes plasticity and gene expression Examines health and stress behaviors after spinal cord injury

Getting Your Brain and Body Back: Everything You Need to Know after Spinal Cord Injury, Stroke, or Traumatic Brain Injury

Author: Bradford C. Berk

Publisher: The Experiment, LLC

Published: 2021-07-13

Total Pages: 322

ISBN-13: 161519696X

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Make the fullest possible recovery after neurological injury with this definitive guide—by a doctor and spinal cord injury survivor who’s been there After an accident that left him permanently paralyzed over ten years ago, Dr. Bradford Berk made it his mission to help others recover from acute neurological injury (ANI). As the founder and director of the University of Rochester Neurorestoration Institute, he brings his abundant experience in working with patients and making his own ongoing recovery to Getting Your Brain and Body Back, the most up-to-date guide for survivors of spinal cord injury (SCI), stroke, and traumatic brain injury (TBI). Each of these acute neurological injuries can result in similar physical and psychological challenges and require similar treatments, medications, and assistive devices. Getting Your Brain and Body Back offers comprehensive, reassuring guidance for your every concern: How to deal with grief and trauma in the aftermath of accident or injury—and build resilience as you find your way forward What adaptive devices—for bathing, dining, mobility, and more—will help you enjoy life to the utmost How to prevent and treat secondary health problems of every kind, such as heart, skin, and bladder troubles—sexual health included! Therapeutic approaches from both Western and Eastern medicine to consider for maximum healing and pain relief Dr. Berk’s candid advice on medical treatment and daily living—plus insights from the brightest minds in the field—will help get you or your loved one back to life.

Spinal Cord Injury

Author: Joost Verhaagen

Publisher: Newnes

Published: 2012-12-31

Total Pages: 677

ISBN-13: 0444535071

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Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

Author: Donald G. Stein

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 400

ISBN-13: 1461309271

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Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.