The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research

The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research PDF

Author: Edward C. Jr. Melby

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 301

ISBN-13: 0323157033

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The Importance of Laboratory Animal Genetics, Health, and the Environment in Biomedical Research documents the proceedings of the Fifth Charles River International Symposium on Laboratory Animals, in Heidelberg, Federal Republic of Germany, March 14-16, 1983. These papers examine how the health and genetic monitoring of laboratory animals, coupled with environmental influences, affect the investigations of oncologists, toxicologists, or pharmacologists. The book is organized into four parts. Part I focuses on the health monitoring of laboratory animals for biomedical research. It includes studies on the effects of health and health monitoring in toxicology studies, oncology studies, and pharmacologic studies. Part II deals with the genetic monitoring of laboratory animals. It examines the causes of genetic alternation in laboratory animals and ways to prevent them. Part III considers the environmental monitoring that is necessary for research on laboratory animals. Part IV on new research frontiers includes studies on the production of monoclonal antibodies for the experimental and therapeutic modulation of laboratory animals, and the quality control aspects of animal experimentation.

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research PDF

Author: National Research Council

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 113

ISBN-13: 0309038391

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Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Guide for the Care and Use of Laboratory Animals

Guide for the Care and Use of Laboratory Animals PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2011-01-27

Total Pages: 246

ISBN-13: 0309154006

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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Critical Needs for Research in Veterinary Science

Critical Needs for Research in Veterinary Science PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2005-10-18

Total Pages: 238

ISBN-13: 0309164982

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Research in veterinary science is critical for the health and well-being of animals, including humans. Food safety, emerging infectious diseases, the development of new therapies, and the possibility of bioterrorism are examples of issues addressed by veterinary science that have an impact on both human and animal health. However, there is a lack of scientists engaged in veterinary research. Too few veterinarians pursue research careers, and there is a shortage of facilities and funding for conducting research. This report identifies questions and issues that veterinary research can help to address, and discusses the scientific expertise and infrastructure needed to meet the most critical research needs. The report finds that there is an urgent need to provide adequate resources for investigators, training programs, and facilities involved in veterinary research.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2003-08-22

Total Pages: 223

ISBN-13: 030916785X

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Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Animal Experimentation: Working Towards a Paradigm Change

Animal Experimentation: Working Towards a Paradigm Change PDF

Author: Kathrin Herrmann

Publisher: BRILL

Published: 2019-04-30

Total Pages: 749

ISBN-13: 9004391193

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Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

The Experimental Animal in Biomedical Research

The Experimental Animal in Biomedical Research PDF

Author: Bernard E. Rollin

Publisher: CRC Press

Published: 1990-08-27

Total Pages: 468

ISBN-13: 9780849349812

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The Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.