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Sherlock's Diseases of the Liver and Biliary System

Author: James S. Dooley

Publisher: John Wiley & Sons

Published: 2018-08-06

Total Pages: 832

ISBN-13: 1119237548

A new, fully updated edition of the world’s most famous book on liver diseases—with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world’s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors’ experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock’s clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.

Diseases of the Liver and Biliary System

Author: Dame Sheila Sherlock

Publisher: Wiley-Blackwell

Published: 1975

Total Pages: 858

ISBN-13: 9780632009114

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The Biliary System

Author: David Q.-H. Wang

Publisher: Biota Publishing

Published: 2016-12-15

Total Pages: 192

ISBN-13: 1615047387

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The liver is a vital organ involved in numerous metabolic processes such as cholesterol and bile acid metabolism, biliary lipid secretion, and bile formation. Cholesterol balance across the liver has a crucial effect on influencing plasma total and LDL cholesterol levels and biliary cholesterol concentrations. Cholesterol and bile acid biosyntheses are primarily modulated by negative feedback regulatory mechanisms through the sterol regulatory element-binding protein isoform 2 (SREBP-2) and the farnesoid X receptor (FXR) pathways, respectively. The conversion of cholesterol to bile acids in the liver can balance the fecal excretion of bile acids, which is an important route for the removal of cholesterol from the body. Bile formation begins in the bile canaliculi, and maintenance of the enterohepatic circulation of bile acids results in a continuous secretion of bile. Hepatic secretion of biliary lipids is determined mainly by a group of ATP-binding cassette (ABC) transporters that are located on the canalicular membrane of hepatocytes, which are regulated by various nuclear receptors. Bile acids promote bile flow by their osmotic effects. Also, they are essential for the intestinal absorption of cholesterol, fatty acids, and fat-soluble vitamins and play an important role in aiding the digestion of dietary fat. Bile acids function as signaling molecules and anti-inflammatory agents to regulate lipid, glucose, and energy metabolism by rapidly activating nuclear receptors and cell signaling pathways. This eBook summarizes the progress in the molecular and cellular mechanisms of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system.

Diffusion Weighted Imaging of the Hepatobiliary System

Author: Celso Matos

Publisher: Springer

Published: 2020-10-28

Total Pages: 0

ISBN-13: 9783319629766

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This book presents the core principles and technical aspects of Diffusion Weighted Imaging (DWI), as well as pearls and pitfalls concerning the imaging technique’s application to the hepatobiliary system. All technical aspects and clinical applications discussed focus on the related anatomical region and its pathologies. Given that magnetic resonance physics is complex and can be cumbersome to learn, the volume editors and authors have made it as simple and practical as possible. Accordingly, tables related to technical details (imaging protocols, artefacts, and optimization techniques) are provided for each chapter. Though DWI is frequently used in the abdomen and pelvis, its clinical role is still evolving, especially for the diagnostic workup of oncologic patients. Although certain efforts have been undertaken to standardize and provide imaging guidelines for different clinical indications, the standardisation and clinical validation of quantitative DWI-related biomarkers are still works in progress. Addressing this gap, the book offers a useful tool for radiologists with a particular interest in abdominal radiology, as well as for radiology residents.

The Biliary System

Author: David Q.-H. Wang

Publisher: Morgan & Claypool Publishers

Published: 2012

Total Pages: 160

ISBN-13: 1615043608

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The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism. Table of Contents: Introduction / Anatomy of the Liver, Biliary Tract, and Gallbladder / Physical Chemistry of Bile / Hepatic Cholesterol Metabolism / Physical Chemistry and Hepatic Metabolism of Bile Acids / The Enterohepatic Circulation of Bile Acids / Hepatic Secretion of Biliary Lipids and Bile Formation / Summary / Acknowledgments / References / Author Biographies

Oxford Handbook of Clinical Pathology

Author: James Carton

Publisher: Oxford University Press

Published: 2017-08-31

Total Pages: 528

ISBN-13: 0191077577

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Now in its second edition, the Oxford Handbook of Clinical Pathology is the concise and rapidly accessible guide to general pathologic principles, and the pathology behind common and important conditions across all the major medical and surgical specialties. Fully updated and now including a brand new chapter on head and neck pathology, this book continues to be the definitive resource for medical students and doctors with an interest in this important specialty. Authored by leading experts, The Oxford Handbook of Clinical Pathology uses the best-selling Oxford Handbook format to cover macroscopic and microscopic features alongside immunohistochemical and molecular pathology in a succinct and practical style. This edition is fully illustrated and now includes over new 50 full colour images and staging information for major malignancies to aid the reader and to explain the pathology of common conditions. This handbook continues to be an indispensable resource in the field for medical students, trainees, and biomedical scientists.

Diseases of the Liver and Biliary System in Children

Author: Deirdre A. Kelly

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 512

ISBN-13: 1405140275

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An extremely practical text, this new edition of Diseases of the Liver and Biliary System in Children covers the essentials of paediatric hepatology. The range of material is wide and has been revised and updated to include the latest advances. Many helpful algorithms and tables are included and the references at the end of each chapter have been carefully selected so as to provide the most up-to-date information available. A concluding section comprising some 100 carefully annotated plates, completes this text. Containing the contributions of 23 internationally acclaimed authorities, active both clinically and in research, the book provides an essential guide to the diagnosis and management of paediatric liver diseases, both common and uncommon for all those involved in the care of the child with liver disease. Diseases of the Liver and Biliary System in Children has become THE REFERENCE of choice for the paediatric gastroenterologist, hepatologist and surgeon.

Pediatric Nuclear Medicine

Author: Leonard M. Freeman

Publisher:

Published: 1975

Total Pages: 232

ISBN-13:

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The Hepatobiliary System

Author: W. Taylor

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 643

ISBN-13: 1461589002

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A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selection of the subjects discussed. The comparison between the two volumes tells something about the advancement in the time interval in knowledge about liver and biliary tract diseases, about the turnover of researchers interested in the liver and its diseases, and also about the present philosophy in biologic science. For this com parison, this volume is particularly suited because, in contrast to many other recent conferences, the more leisurely pace of the NATO Institutes permits more comprehensive but still scholarly reviews of the problems. The foreword of the first volume, written by my colleague, the late Harry Sobotka, expresses his, now dated, astonishment about the progress of knowledge of biology of the bile, so much less accessible to study than urine.

Biliary Tract Radiology

Author: Plinio Rossi

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 417

ISBN-13: 3642603432

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This book, edited by Prof. PLINIO ROSSI, an internationally well-known expert in biliary tract radiology, provides in 31 chapters a very comprehensive update on both diagnostic and therapeutic radiology of the biliary tract. First, a very complete and interesting overview of the normal morphology of the ana tomical area is presented by an anatomist, a radiologist, and a surgeon. This is followed by a discussion not only of the well-known and accepted imaging modalities, but also of the newer ones such as, magnetic resonance imaging and endoluminal and laparoscopic ultra sound. The book thus illustrates very nicely the diversity of diagnostic radiological tech niques that are currently available. Considerable technical progress and remarkable new insights in biliary tract radiology have been achieved in the field of the radiological interventional approach during recent years. Therefore, much emphasis has been placed in this book on the therapeutic possibili ties of the radiologist using the percutaneous minimally invasive approach for the treat ment of the various pathological conditions of the biliary tract. It is most impressive to note the substantial progress in terms of patient comfort achieved by using the percutaneous as compared to the surgical methods. These new methods also result in shorter hospitalization times and thereby help to reduce health care costs. This book provides the interested reader with a fascinating and very complete over view of these new procedures.