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The Computational Mechanics of Bone Tissue

Author: Jorge Belinha

Publisher: Springer Nature

Published: 2020-02-11

Total Pages: 249

ISBN-13: 3030375412

This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.

The Computational Mechanics of Bone Tissue

Author:

Publisher:

Published: 2020

Total Pages: 249

ISBN-13: 9783030375423

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Finite Element Analysis of Bone Remodeling. Implementation of a Remodeling Algorithm in MATLAB and ANSYS

Author: Martin Groß

Publisher: GRIN Verlag

Published: 2008-08-18

Total Pages: 111

ISBN-13: 3640139933

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Master's Thesis from the year 2006 in the subject Medicine - Biomedical Engineering, grade: 1.0, Technical University of Munich (LS Statik), course: Master of Science of Computational Mechanics, language: English, abstract: The process of adaptive bone remodeling can be described mathematically and simulated in a computer model, integrated with the finite element method. The main focus of this thesis is the implementation of a bone remodeling algorithm in MATLAB and ANSYS on the basis of FEM. The strain energy density is used as mechanical stimulus. The cortical and trabecular bone are described as continuous materials with variable density. This thesis can be divided into four main parts. The first part is due to the material properties of cortical and trabecular bone. The second part is about the remodeling theory and gives an historical review of the developed numerical approaches up to now. The implementation of the remodeling algorithm in ANSYS and MATLAB as well as its validation is topic of part three. In last main part, the algorithm is applied to a 2D FE-model of a human proximal femur.

Meshless Methods in Biomechanics

Author: Jorge Belinha

Publisher: Springer

Published: 2014-05-14

Total Pages: 328

ISBN-13: 3319064002

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This book presents the complete formulation of a new advanced discretization meshless technique: the Natural Neighbour Radial Point Interpolation Method (NNRPIM). In addition, two of the most popular meshless methods, the EFGM and the RPIM, are fully presented. Being a truly meshless method, the major advantages of the NNRPIM over the FEM and other meshless methods, are the remeshing flexibility and the higher accuracy of the obtained variable field. Using the natural neighbour concept, the NNRPIM permits to determine organically the influence-domain, resembling the cellulae natural behaviour. This innovation permits the analysis of convex boundaries and extremely irregular meshes, which is an advantage in the biomechanical analysis, with no extra computational effort associated. This volume shows how to extend the NNRPIM to the bone tissue remodelling analysis, expecting to contribute with new numerical tools and strategies in order to permit a more efficient numerical biomechanical analysis.

Computational Modeling in Tissue Engineering

Author: Liesbet Geris

Publisher: Springer Science & Business Media

Published: 2012-10-30

Total Pages: 438

ISBN-13: 3642325637

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One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Bone Remodeling Process

Author: Rabeb Ben Kahla

Publisher: Academic Press

Published: 2021-08-14

Total Pages: 238

ISBN-13: 0323902057

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Bone Remodeling Process: Mechanics, Biology, and Numerical Modeling provides a literature review. The first part of the book discusses bones in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and the second discusses pathological conditions, highlighting the attack vectors of each bone disease. The third part is devoted to the mathematical descriptions of bone remodeling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics.This book creates an overall image of the complex communication network established between the diverse remodeling actors, based on overwhelming control evidence revealed over recent years, as well as visualizes the remodeling defects and possible treatments in each case. It also regroups the models allowing readers to analyze and assess bone mechanical and biological properties. This book details the cellular mechanisms allowing the bone to adapt its microarchitecture to the requirements of the human body, which is the main issue in bone biology and presents the evolution of mathematical modeling used in a bone computer simulation. Each chapter covers a core topic in bone biomechanics Provides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulation Draws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodeling process

Skeletal Tissue Mechanics

Author: R. Bruce Martin

Publisher: Springer

Published: 2015-10-29

Total Pages: 513

ISBN-13: 1493930028

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This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

Computational Simulation Of Bone Tissue Remodeling Process

Author: Jorge Belinha

Publisher:

Published: 2017

Total Pages:

ISBN-13:

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Introduction: Bone is a living tissue, capable to structurally react to external stimuli, such as mechanical loading. In this work, bone tissue adaptation to mechanical loading is predicted by means of a friendly computational tool using an advanced topologic optimization mathematical model for bone remodeling.Objectives: The aim of this work was to deliver a mature computational tool capable to predict the bone tissue remodeling in several scenarios, such as healthy or cancerous bone structures requiring implants.Methods: In order to obtain the computational discretization of the bone structure, discrete numerical methods are used, such as the Finite Element Method and meshless methods. Then, the remodeling algorithm seeks the minimization of the strain energy density field and considers a phenomenological law capable to predict the bone tissue's mechanical properties based on the bone apparent density.Results: In this work, several clinical cases are studied, such as the remodeling simulation of a femur submitted to a hip replacement surgery, whose head was removed due to a cancer. The virtual results show that, using the proposed computational tool, it is possible to predict the trabecular distribution of bone structures, with or without femoral stems, as figure 1 shows.Conclusions: The numerical results obtained with the proposed computational tool do not perfectly match the reality. However, they are excitingly close, allowing the physician to select the most suited implant solution for each patient. Additionally, this mature computational tool was successfully used by trainee orthopedists and dentists, with no engineering background, showing its potential in the daily clinical practice. AcknowledgementsThe authors truly acknowledge the funding provided by Ministu00e9rio da Ciu00eancia, Tecnologia e Ensino Superior u2013 Fundau00e7u00e3o para a Ciu00eancia e a Tecnologia (Portugal), under grants: SFRH/BPD/111020/2015 and SFRH/BD/133105/2017 and by project funding MIT-EXPL/ISF/0084/2017. Additionally, the authors gratefully acknowledge the funding of Project NORTE-01-0145-FEDER-000022 u2013 SciTech u2013 Science and Technology for Competitive and Sustainable Industries, co-financed by Programa Operacional Regional do Norte (NORTE2020), through Fundo Europeu de Desenvolvimento Regional (FEDER).References[1]tBelinha, J. (2014). Meshless Methods in Biomechanics u2013 Bone Tissue Remodelling Analysis. (J.M. R. S. Tavares & R. M. Natal Jorge, Eds.) (Vol. 16 ed.,p. 320). Lecture Notes in Computational Vision and Biomechanics, Springer Netherlands.

Bone Mechanics

Author: Stephen C. Cowin

Publisher: CRC Press

Published: 1989

Total Pages: 336

ISBN-13:

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This informative volume summarizes what is known about bone mechanics. It describes the methods used to acquire that knowledge and suggests the nature of future research on this topic. This easy-to-read book keeps mathematical notation simple and minimal and presents data in summary form. Bone Mechanics is concerned with the mechanical behavior and functional stress adaptation of whole bones as structural elements, the mechanical behavior and functional adaptation of bone tissue as material, and the physiological significance of the mechanical properties of bone and the biological response of bone to applied stress. Orthopaedic surgeons, dentists, anatomists, biologists, biomedical engineers and physiologists are among those who will find this volume to be of interest.

Biomedical Imaging and Computational Modeling in Biomechanics

Author: Ugo Andreaus

Publisher: Springer Science & Business Media

Published: 2012-10-09

Total Pages: 208

ISBN-13: 940074269X

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This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease. The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis