The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I
Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
Published: 2022-02-02
Total Pages: 153
ISBN-13: 2889742512
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The biochemistry of amyloids in neurodegenerative diseases, volume II
Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
Published: 2023-07-19
Total Pages: 193
ISBN-13: 2832529798
DOWNLOAD EBOOK →Amyloid Proteins
Author: Einar M. Sigurdsson
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 390
ISBN-13: 1592598749
DOWNLOAD EBOOK →A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
Author: J. Robin Harris
Publisher: Springer Science & Business Media
Published: 2012-12-09
Total Pages: 654
ISBN-13: 9400754167
DOWNLOAD EBOOK →This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.
Biophysics And Biochemistry Of Protein Aggregation: Experimental And Theoretical Studies On Folding, Misfolding, And Self-assembly Of Amyloidogenic Peptides
Author: Yuan Jian-min
Publisher: World Scientific
Published: 2017-06-02
Total Pages: 328
ISBN-13: 9813202394
DOWNLOAD EBOOK →This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.
Brain Diseases and Metalloproteins
Author: David R. Brown
Publisher: CRC Press
Published: 2012-08-07
Total Pages: 432
ISBN-13: 981436407X
DOWNLOAD EBOOK →This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson's disease, Alzheimer's disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induce
Amyloid Diseases
Author: Dmitry Kurouski
Publisher: BoD – Books on Demand
Published: 2019-08-07
Total Pages: 244
ISBN-13: 1789853818
DOWNLOAD EBOOK →Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?
Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
Author: J. Robin Harris
Publisher: Springer Science & Business Media
Published: 2006-11-22
Total Pages: 416
ISBN-13: 0387232265
DOWNLOAD EBOOK →To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Amyloid Diseases
Author: Dmitry Kurouski
Publisher:
Published: 2019
Total Pages: 242
ISBN-13: 9781789853827
DOWNLOAD EBOOK →Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?
Molecular Mechanisms of Neurodegenerative Diseases
Author: Marie-Francoise Chesselet
Publisher: Springer Science & Business Media
Published: 2000-10-19
Total Pages: 416
ISBN-13: 1592590063
DOWNLOAD EBOOK →With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
