The Anthrax Vaccine

The Anthrax Vaccine PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2002-04-18

Total Pages: 288

ISBN-13: 0309182743

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The vaccine used to protect humans against the anthrax disease, called Anthrax Vaccine Adsorbed (AVA), was licensed in 1970. It was initially used to protect people who might be exposed to anthrax where they worked, such as veterinarians and textile plant workers who process animal hair. When the U. S. military began to administer the vaccine, then extended a plan for the mandatory vaccination of all U. S. service members, some raised concerns about the safety and efficacy of AVA and the manufacture of the vaccine. In response to these and other concerns, Congress directed the Department of Defense to support an independent examination of AVA. The Anthrax Vaccine: Is It Safe? Does It Work? reports the study's conclusion that the vaccine is acceptably safe and effective in protecting humans against anthrax. The book also includes a description of advances needed in main areas: improving the way the vaccine is now used, expanding surveillance efforts to detect side effects from its use, and developing a better vaccine.

The Anthrax Immunization Program

The Anthrax Immunization Program PDF

Author: United States. Congress. House. Committee on Government Reform. Subcommittee on National Security, Veterans Affairs, and International Relations

Publisher:

Published: 1999

Total Pages: 126

ISBN-13:

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An Assessment of the CDC Anthrax Vaccine Safety and Efficacy Research Program

An Assessment of the CDC Anthrax Vaccine Safety and Efficacy Research Program PDF

Author: Committee to Review the CDC Anthrax Vaccine Safety and Efficacy Research Program

Publisher: National Academies Press

Published: 2002-11-25

Total Pages: 179

ISBN-13: 0309168953

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In 1998, the Department of Defense (DoD) began a program of mandatory immunization against anthrax for all military personnel. As the program proceeded, however, some military personnel and their families raised concerns about the safety and efficacy of the anthrax vaccine. Acknowledging both the need to protect military personnel and the concerns about the anthrax vaccine, congress directed the Centers for Disease Control and Prevention (CDC) to carry out a research program on its safety and efficacy. To assist in the development of this program, CDC requested the Institute of Medicine (IOM) to convene a committee to review the completeness and appropriateness of the research program. In An Assessment of the CDC Anthrax Vaccine Safety and Efficacy Research Program, the committee makes an overall assessment of the CDD research plan and reviews the specific studies proposed by CDC in the three areas of efficacy, safety and acceptability. The committee also notes additional research needs that became evident following the bioterrorist events of 2001 and makes recommendations about the leadership of the research program.

The Anthrax Vaccine Debate

The Anthrax Vaccine Debate PDF

Author: Usaf Counterproliferation USAF Counterproliferation Center

Publisher: CreateSpace

Published: 2015-06-02

Total Pages: 58

ISBN-13: 9781514130353

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On 6 February 2000, 60 Minutes aired an interview of an active duty Air Force major who had refused to receive the vaccine for anthrax.1 Viewers learned that he faced the potential of a court-martial for refusing to obey orders.2 The major's refusal is just one aspect of a complex controversy surrounding the Department of Defense's Anthrax Vaccination Immunization Program.3 Adding to the confusion are a myriad of press releases, communications and opinions from concerned individuals on the internet, Congressional testimony, issues raised by those in the Reserve Components regarding any potential effects on their civilian careers, and numerous internet web sites both supporting and opposing vaccination. Needless to say the anthrax vaccine debate is extremely complex. It is possible, however, to categorize the issues and concerns with the Anthrax Vaccine Immunization Program as either clinically related or administrative policy related, then address the two categories separately.4 An important aspect of the clinically related issues is to determine if the anthrax vaccine, Anthrax Vaccine, Adsorbed (AVA), is safe and provides effective protection against the effects of exposure to anthrax spores. What is needed is a clinical assessment based on data in the published, peer-reviewed medical literature and medical textbooks.5 In addition, it is necessary to assess if credible alternatives to vaccination using Anthrax Vaccine, Adsorbed exist. If medical personnel determine the vaccine is clinically safe and effective, as documented in the medical literature, then administrative policy-makers may determine if the vaccine should be administered to Department of Defense personnel. The decision to vaccinate Defense Department personnel is a policy decision made by those in the legal chain of command and is based on intelligence estimates and relative risk assessments related to the potential use of anthrax spores in a biological weapon. Clinicians and Service medical corps officers do not set policy. Nor do they have the authority to order vaccination of all personnel. The intent of this paper is to provide military commanders and supervisors with pertinent clinical facts and information about anthrax and Anthrax Vaccine, Adsorbed in a single source document, written in lay terms, to serve as a working reference for use to educate those within their chain of command. Due to time and space limitations, this paper is not intended to be an exhaustive review.6 Reviews and discussions of the evidence related to the risk of the use of anthrax as a biological weapon and the policy decision to vaccinate Defense Department personnel are beyond the scope of this paper, which focuses instead on clinical issues related to the vaccine. The paper will present a brief review of anthrax, including a description of the causative organism and how it causes disease in humans, along with a review of the history of the vaccine and its manufacturer. Next, the paper will provide an overview of the medical literature to address safety, efficacy, side effects, and complications from vaccination, followed by the major points of controversy found in the media, on information world-wide-web sites, and in Congressional testimony. Then, the paper will attempt to bring the controversy into perspective, examining several of the arguments of those opposed to vaccination against anthrax, followed by presenting some conclusions and recommendations. The research methods employed for this paper include a review of the peer-reviewed medical literature, medical textbooks, press releases, and internet world-wide-web sites presenting information and opinions both for and against vaccination.