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The Amazing World of IDPs in Human Diseases

Author: Simona Maria Monti

Publisher: MDPI

Published: 2021-06-15

Total Pages: 196

ISBN-13: 3036510281

It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.

The Amazing World of IDPs in Human Diseases

Author: Simona Maria Monti

Publisher:

Published: 2021

Total Pages: 196

ISBN-13: 9783036510293

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The Amazing World of IDPs in Human Diseases II

Author: Simona Maria Monti

Publisher: Mdpi AG

Published: 2022-04-05

Total Pages: 130

ISBN-13: 9783036531076

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This Special Issue includes seven full articles from more than 35 scientists from all around the world working in the amazing field of IDPs. The collected papers unveil novel aspects related to the wide world of IDPs. Using a variety of methods including biochemical, spectroscopic and computational techniques, they represent a step forward in the study and characterization of many IDPs involved in human diseases, with a focus on conformational features, environmental effects, recognition mechanisms and targeting.

Human Diseases and Conditions

Author: Miranda Herbert Ferrara

Publisher: Charles Scribner's Sons

Published: 2010

Total Pages: 584

ISBN-13:

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This volume presents alphabetically arranged articles dealing with all kinds of diseases and disorders, from salmonellosis to zoonoses.

Intrinsically Disordered Proteins

Author: Vladimir N. Uversky

Publisher: Springer

Published: 2014-08-05

Total Pages: 73

ISBN-13: 3319089218

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In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Phenotypic Switching

Author: Herbert Levine

Publisher: Academic Press

Published: 2020-06-10

Total Pages: 773

ISBN-13: 012817997X

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Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

Genocidal Attacks Against Christian and Other Religious Minorities in Syria and Iraq

Author: United States. Congress. House. Committee on Foreign Affairs. Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations

Publisher:

Published: 2014

Total Pages: 124

ISBN-13:

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Flexible Viruses

Author: Vladimir Uversky

Publisher: John Wiley & Sons

Published: 2012-02-07

Total Pages: 532

ISBN-13: 0470618310

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This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

World Development Report 1978

Author:

Publisher: World Bank Publications

Published: 1978

Total Pages: 135

ISBN-13: 0821372823

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This first report deals with some of the major development issues confronting the developing countries and explores the relationship of the major trends in the international economy to them. It is designed to help clarify some of the linkages between the international economy and domestic strategies in the developing countries against the background of growing interdependence and increasing complexity in the world economy. It assesses the prospects for progress in accelerating growth and alleviating poverty, and identifies some of the major policy issues which will affect these prospects.