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Targeting a Cure for Type 1 Diabetes: How Long Will We Have to Wait?

Author: Lisa S. Rotenstein

Publisher: American Diabetes Association

Published: 2013-04-17

Total Pages: 121

ISBN-13: 1580405045

Will type 1 diabetes ever be cured? Everyone whose lives are touched by type 1 diabetes hopes for a cure but hard facts are difficult to find. Targeting a Cure for Type 1 Diabetes chronicles the diverse efforts now underway to answer this critical question. The writers from diaTribe (www.diaTribe.org), an award-winning free online newsletter about diabetes, have collaborated with the American Diabetes Association to explain the research and to lay out their objective assessment of each therapy—giving readers a clear understanding of the potential each treatment holds and the optimism each deserves. Highlighting the opportunities and obstacles, this book focuses on the four most promising research areas: immune therapeutics, islet and pancreas transplantation, beta-cell regeneration and survival agents, and the artificial pancreas. As a person who has lived with type 1 diabetes for 26 years and an expert on the business of diabetes therapies, diaTribe editor-in-chief Kelly Close understands the weight of this all-important question and provides her personal commentary on where we stand in the search for a cure. The book features a foreword by Dr. Robert Ratner, Chief Scientific and Medical Officer for the American Diabetes Association, and an introduction from Dr. Aaron Kowalski, Vice President, Treatment Therapies, for JDRF. As they remind us, the search for the cure is ultimately about patients, and this book is written to give you true hope—one that is strengthened by data and facts. After reading about Kelly Close and her teams’ incredible journey of discovery, we cannot only continue to dream, but we can open our eyes each morning to a reality that brings us closer, inch by inch, discovery by discovery, to a day when glucose control will be automatic and people with type 1 diabetes will be “cured.” —Dr. Francine Kaufman, Chief Medical Officer and Vice President, Medtronic Diabetes

Targeting a Cure for Type 1 Diabetes

Author: Lisa Rotenstein

Publisher:

Published: 2011-07-28

Total Pages: 162

ISBN-13: 9781463746377

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Every person touched by diabetes wants to know when there will be a cure. A lot of work is going on, but what are the chances of a breakthrough? Targeting a Cure for Type 1 Diabetes is a comprehensive overview of where we are and where we're headed in that search. Rich in detail and written for patients and their families, the book features the latest information on the most promising approaches for curing diabetes. These include immune therapeutics, islet and pancreas transplantation, beta cell regeneration agents, and the artificial pancreas.Published by diaTribe (www.diatribe.us), a free newsletter for people with diabetes, the book features an introduction by Dr. Aaron Kowalski of the JDRF and concluding remarks by diaTribe's Editor in Chief, Kelly Close. Targeting a Cure for Type 1 Diabetes is essential reading for anyone who wants to know more about what a cure might look like or when it will be available. Although a cure may not be right around the corner, this book lays bare the possibilities of all the exciting research now underway.

Technological Advances in the Treatment of Type 1 Diabetes

Author: D. Bruttomesso

Publisher: Karger Medical and Scientific Publishers

Published: 2014-11-17

Total Pages: 274

ISBN-13: 331802337X

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The current epidemic of diabetes, obesity and related disorders is a driving force in the development of new technologies. Technological advances offer great new opportunities for the treatment of these chronic diseases. This review presents an update of developments that promise to revolutionize the treatment of diabetes. It examines hospital and outpatient care, intensive insulin therapy, blood glucose monitoring and innovative steps towards the construction of an artificial pancreas. Providing a comprehensive overview on the latest advances, this volume of Frontiers in Diabetes will be of particular interest to all healthcare providers involved in the daily management of patients with diabetes or related diseases.

The Type 1 Diabetes Self-Care Manual

Author: Wood Jamie

Publisher: American Diabetes Association

Published: 2017-11-08

Total Pages: 190

ISBN-13: 1580406920

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The Type 1 Diabetes Self-Care Manual: A Complete Guide to Type 1 Diabetes Across the Lifespan for People with Diabetes, Parents, and Caregivers offers practical, evidence-based and common sense help for people with type 1 diabetes and their caregivers. For the close to 1.5 million people with type 1 diabetes in the United States alone and their family and friends, this book will help them understand the effects of type 1 diabetes, not just when diagnosed, but throughout their lifespan. Dr. Jamie Wood and Dr. Anne Peters, two of the most respected and sought-after endocrinologists, provide an easy-to-follow narrative on all aspects of the disease. The Type 1 Diabetes Self-Care Manual will be the go-to reference for everyone touched by type 1 diabetes.

Translating tolerogenic therapies to the clinic – where do we stand and what are the barriers?

Author: Stephen P. Cobbold

Publisher: Frontiers E-books

Published:

Total Pages: 233

ISBN-13: 2889190994

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This Research Topic is a call for papers to provide an up to date assessment of current attempts to introduce tolerogenic therapies into clinical practice. Tolerance has been a highly sought after goal in the field of organ transplantation for over half a century, and is now readily achievable in rodent models, but considerable barriers remain to successfully translating tolerogenic treatments to the clinic. The initial call for this Research Topic has been aimed to provide an overview of recent advances made within the European RISET and American ITN networks with regard to tolerogenic strategies in clinical transplantation, autoimmune disease, and allergy. Articles will also cover the barriers to clinical tolerance induction and new emerging approaches to overcome such barriers. 1. Collaborative networks working towards the goal of therapeutic tolerance induction 2. Prope tolerance and minimization of immunosuppression 3. Lessons from operationally tolerant patients 4. Targeted withdrawal of immunosuppression 5. Stem cells and hematopoietic chimerism as a route to tolerance 6. Promoting regulatory T cells 7. Tolerogenic dendritic cells and negative vaccination 8. Inhibitory pathways and mechanisms in tolerance 9. Memory T cells and heterologous immunity 10. The innate response to allotransplants 11. Chronic graft loss--what are the missing links? 12. The impact of graft microenvironment on tolerance

Type 1 diabetes: insulin treatment

Author: Sics Editore

Publisher: SICS Editore

Published: 2014-10-01

Total Pages: 49

ISBN-13: 8869304833

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The missing insulin production of the pancreas is replaced by individual administration of different insulin preparations into the subcutaneous fat through injections or an insulin pump.In a patient with insulin deficiency, the administration of basal insulin must not be discontinued in any circumstances even if it may be necessary to reduce the dose in certain situations.A regime based on multiple daily insulin injections is the primary treatment mode in a patient with type 1 diabetes. It mimics normal insulin secretion at night and between mealtimes (basal insulin) as well as during mealtimes (mealtime insulin).Even in good diabetes control the blood glucose concentrations vary (due to, e.g., variation in insulin absorption, food composition and gastric emptying as well as stress, sickness, exercise, menstrual cycle). Temporary high concentrations are corrected with additional doses of rapid-acting insulin (corrective insulin) administered at meals.The patient is taught to adjust the insulin dosage him-/herself according to the daily rhythms, eating patterns, exercise and self-monitoring of blood glucose (plasma glucose concentration). Good treatment results are based on sufficient guidance as well as continuity of carethe patient’s acceptance of the disease as a part of one’s own lifesufficient and reasonable self-monitoring of blood glucose and actions taken according to the measurement results the ability of the patient to master the daily care of his illness shared, neutral and empowering problem solving. The individual aims and modes of treatment should be decided with the patient, taking into account the current life situation, the patient’s proneness to hypoglycaemia and the ability of the patient to carry out the treatment himself/herself.Hypoglycaemias and the fear of them may pose an essential obstacle to good control of diabetes. If good glycaemic control is not achieved (HbA1c exceeds the individually set target, episodes of severe hypoglycaemia or wide daily variations in blood glucose concentration occur) with an appropriate multiple injection regime consisting of rapid-acting and long-acting insulin derivatives, the patient is referred for glucose sensor monitoring and for consideration of an insulin pump. In type 1 diabetes, blood pressure and blood lipids must also be in good control.

Dr. Bernstein's Diabetes Solution

Author: Richard K. Bernstein

Publisher: Little, Brown

Published: 2011-11-01

Total Pages: 465

ISBN-13: 0316191736

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Originally published in 1997, DR. BERNSTEIN'S DIABETES SOLUTION is a unique resource that covers both adult- and childhood-onset diabetes, explains step-by-step how to normalize blood sugar levels and prevent or reverse complications, and offers detailed guidelines for establishing a treatment plan. Readers will find fifty gourmet recipes, in addition to a comprehensive discussion of diet, obesity, and new drugs to curb carbohydrate craving and overeating. Now in its fourth edition, the book presents up-to-the-minute information on insulin resistance, blood-testing devices, measuring blood sugar, new types of insulin, gastroparesis and other issues, as well as updated diet guidelines. DR. BERNSTEIN'S DIABETES SOLUTION is the one book every diabetic must own.

Brocklehurst's Textbook of Geriatric Medicine and Gerontology E-Book

Author: Howard M. Fillit

Publisher: Elsevier Health Sciences

Published: 2010-05-10

Total Pages: 1171

ISBN-13: 1437720757

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Popular with generations of practitioners, Brocklehurst's Textbook of Geriatric Medicine and Gerontology has been the definitive reference of choice in the field of geriatric care. The new 7th Edition, by Howard M. Fillit, MD, Kenneth Rockwood, MD, and Kenneth Woodhouse, carries on this tradition with an increased clinical focus and updated coverage to help you meet the unique challenges posed by this growing patient population. Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy, while over 255 illustrations compliment the text to help you find what you need on a given condition. Examples of the latest imaging studies depict the effects of aging on the brain, and new algorithms further streamline decision making. Emphasizes the clinical relevance of the latest scientific findings to help you easily apply the material to everyday practice. Features consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more that make reference quick and easy. Includes over 255 illustrations—including algorithms, photographs, and tables—that compliment the text to help you find what you need on a given condition. Provides summary boxes at the end of each chapter that highlight important points. Features the work of an expert author team, now led by Dr. Howard M. Fillit who provides an American perspective to complement the book’s traditional wealth of British expertise. Includes an expanded use of algorithms to streamline decision making. Presents more color images in the section on aging skin, offering a real-life perspective of conditions for enhanced diagnostic accuracy. Includes examples of the latest imaging studies to help you detect and classify changes to the brain during aging. Offers Grade A evidence-based references keyed to the relevant text.

Approach to Internal Medicine

Author: David Hui

Publisher: Springer Nature

Published: 2022-01-31

Total Pages: 540

ISBN-13: 303072980X

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The fully updated fifth edition of this highly successful textbook provides an integrated symptom- and issue-based approach to internal medicine with easily accessible, high-yield clinical information. For each topic, carefully organized sections on different diagnoses, investigations, and treatments are designed to facilitate patient care and examination preparation. Numerous clinical pearls and comparison tables are provided to help enhance learning, and international units (US and metric) are used to facilitate application in everyday clinical practice. In addition to the central tenets of internal medicine, the book covers many highly important, rarely discussed topics in medicine, including: palliative care, obstetrical medicine, transfusion reactions, needle stick injuries, interpretation of gram stain, depression and code status discussion. This fifth edition additionally includes new coverage of the coronavirus-19 and cancer survivorship while being fully updated throughout. Authors present this information in a streamlined fashion, preserving the book’s pocket-sized, quick reference format. Approach to Internal Medicine continues to serve as an essential reference primarily for medical students, residents, and fellows -- with practicing physicians, nurses, and advanced practice providers also finding the text of value as a point of care reference.

Advanced Nutrition and Dietetics in Diabetes

Author: Louise Goff

Publisher: John Wiley & Sons

Published: 2015-12-30

Total Pages: 358

ISBN-13: 0470670924

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Published on behalf of The British Dietetic Association, Advanced Nutrition and Dietetics in Diabetes is an exploration of the evidence and practice of nutrition in diabetes, offering a global view of the lifestyle interventions for the prevention and management of diabetes, including management of complications and special population groups. With internationally recognised authors, this book applies the rigour of evidence-based medicine to important enduring topics in diabetes, such as: public health efforts at diabetes prevention formulating nutritional guidelines for diabetes carbohydrates and the glycaemic index the management of diabetes in older people The authors draw on their research and practical experience to offer sound guidance on best practice, ensuring that interventions are both scientifically secure and effective. ABOUT THE SERIES Dietary recommendations need to be based on solid evidence, but where can you find this information? The British Dietetic Association and the publishers of the Manual of Dietetic Practice present an essential and authoritative reference series on the evidence base relating to advanced aspects of nutrition and diet in selected clinical specialties. Each book provides a comprehensive and critical review of key literature in its subject. Each covers established areas of understanding, current controversies and areas of future development and investigation, and is oriented around six key themes: Disease processes, including metabolism, physiology, and genetics Disease consequences, including morbidity, mortality, nutritional epidemiology and patient perspectives Nutritional consequences of diseases Nutritional assessment, drawing on anthropometric, biochemical, clinical, dietary, economic and social approaches Clinical investigation and management Nutritional and dietary management Trustworthy, international in scope, and accessible, Advanced Nutrition and Dietetics is a vital resource for a range of practitioners, researchers and educators in nutrition and dietetics, including dietitians, nutritionists, doctors and specialist nurses.