Target product profile for HIV drug resistance tests in low- and middle-income countries: Africa

Target product profile for HIV drug resistance tests in low- and middle-income countries: Africa PDF

Author: World Health Organization

Publisher: World Health Organization

Published: 2023-09-12

Total Pages: 30

ISBN-13: 9240076662

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HIV-1 drug resistance tests may be useful tools for optimizing ART regimens when used in the context of information about viral load, immune and clinical status, adherence practices and available treatment options. Several types of drug resistance tests are available, either as commercial kits or based on published methods for in-house assays. The target product profile for HIV drug resistance tests in low- and middle-income countries: Africa is designed to guide the development of new HIV drug resistance tests in the era of dolutegravir-based antiretroviral therapy (ART) and to facilitate the evaluation of the suitability of currently available HIV drug resistance tests for specific applications. The target product profiles focus on the new-term future for available ART regimens and their use and anticipates an innovate test that will meet the projected demand.

Global HIV/AIDS Medicine

Global HIV/AIDS Medicine PDF

Author: Paul Volberding

Publisher: Elsevier Health Sciences

Published: 2008

Total Pages: 850

ISBN-13: 141602882X

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HIV/AIDS management poses many different challenges around the world, and the therapies available in the West are often not economically feasible in developing countries. This new book is the first to address the myriad of clinical difficulties faced by health practitioners worldwide in managing HIV/AIDS. Edited by the same authorities responsible for the highly respected reference "The Medical Management of AIDS," with Associate Editors that include the President of the International AIDS Society and a preeminent opinion leader in the fight against AIDS in Africa, and authored by a "who's who" of current global experts on HIV and AIDS medicine, this visionary text presents all the practical, indispensable information that clinicians everywhere need to offer their patients the best possible care. Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers. Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians. Diagnose AIDS manifestations confidently by comparing them to full-color clinical images. Review essential data quickly through numerous at-a-glance tables.

Ethics and Drug Resistance: Collective Responsibility for Global Public Health

Ethics and Drug Resistance: Collective Responsibility for Global Public Health PDF

Author: Euzebiusz Jamrozik

Publisher: Springer

Published: 2021-08-21

Total Pages: 448

ISBN-13: 9783030278762

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This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Handbook of Antimicrobial Resistance

Handbook of Antimicrobial Resistance PDF

Author: Matthias Gotte

Publisher: Springer

Published: 2018-02-12

Total Pages: 0

ISBN-13: 9781493906932

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While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection

Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection PDF

Author: World Health Organization

Publisher:

Published: 2016

Total Pages: 429

ISBN-13: 9789241549684

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These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.

House on Fire

House on Fire PDF

Author: William H. Foege

Publisher: Univ of California Press

Published: 2011-06-06

Total Pages: 240

ISBN-13: 0520268369

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“Bill Foege takes us inside the world's greatest public health triumph: the eradication of smallpox. It's a story of true determination, passion and courage. The story of smallpox should encourage all of us to continue the critical work of worldwide disease eradication.”--Bill Gates, Co-Chair of the Bill & Melinda Gates Foundation “Bill Foege is one of the public health giants of our times. He was responsible for the design of the campaign that eradicated smallpox—the most important global health achievement in history and possibly the greatest feat in any field of international cooperation. His insights into the nature of this major event will undoubtedly help to meet the global health challenges of the 21st century.”—Julio Frenk, M.D, PhD, Dean, Harvard School of Public Health “The eradication of a disease has long been the holy grail of global health and Bill Foege found it: more than any other person, he was responsible for the eradication of smallpox from the face of the earth. This is a story told by a remarkably humble man, about the extraordinary coalition that he helped to build, and the most impressive global health accomplishment the world has ever seen.”—Mark Rosenberg, author of Real Collaboration: What It Takes for Global Health to Succeed “I am thrilled that Bill Foege, one of the great heroes of the smallpox eradication campaign, has written this important book. It tells a beautiful human story of an incredible public health triumph, and is full of lessons that could be applied to many of the global challenges we face today.”—Helene D. Gayle MD, President and CEO, CARE USA “Bill Foege’s House on Fire is the first-hand account of how a revised strategy to eradicate smallpox was tested, validated, and applied. Without the global adoption of this new surveillance strategy, the final deathblow to this longtime global menace might never have been dealt.”—Adetokunbo O. Lucas, MD, DSc, author of It Was The Best of Times: From Local to Global Health “Smallpox is the most devastating disease the world has known, as it destroyed lives and shaped history over the centuries. House on Fire provides a day-to-day account by my friend Dr. Bill Foege of the battle required to defeat this wily and diabolic virus."--President Jimmy Carter