Synaptic Assembly and Neural Circuit Development
Author: Jaewon Ko
Publisher: Frontiers Media SA
Published: 2018-11-02
Total Pages: 191
ISBN-13: 2889456307
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Synaptic Assembly and Neural Circuit Development
Author:
Publisher:
Published: 2018
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOK →Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of 'precise' synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations.
Synapse Development and Maturation
Author: Pasko Rakic
Publisher: Academic Press
Published: 2020-05-29
Total Pages: 560
ISBN-13: 0128236736
DOWNLOAD EBOOK →Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate synapse formation and maintenance during development Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Intercellular Communication in the Nervous System
Author: Robert Malenka
Publisher: Academic Press
Published: 2010-05-22
Total Pages: 777
ISBN-13: 0123785723
DOWNLOAD EBOOK →Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signaling. Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more Richly illustrated in full color with over 200 figures Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge
Make Life Visible
Author: Yoshiaki Toyama
Publisher: Springer Nature
Published: 2019-10-02
Total Pages: 292
ISBN-13: 9811379084
DOWNLOAD EBOOK →This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Neural Circuit Development and Function in the Healthy and Diseased Brain
Author:
Publisher: Academic Press
Published: 2013-05-06
Total Pages: 849
ISBN-13: 0123973465
DOWNLOAD EBOOK →The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development
Development of Neural Circuitry
Author:
Publisher: Academic Press
Published: 2009-05-07
Total Pages: 253
ISBN-13: 0080922619
DOWNLOAD EBOOK →The nervous system is highly complex both in its structural order and in its ability to perform the many functions required for survival and interaction with the environment; understanding how it develops has proven to be one of the greatest challenges in biology. Such precision demands that key events at every developmental stage are executed properly and are coordinated to produce the circuitry underlying each of the adult nervous system's functions. This volume describes the latest research on the cellular and molecular mechanisms of neural circuitry development, while providing researchers with a one-stop overview and synthesis of contemporary thought in the area. Reviews current research findings on the development of neural circuitry, providing researchers with an overview and synthesis of the latest contemporary thought in the cellular and molecular mechanisms that underlie the development of neural circuitry Includes chapters discussing topics such as the guidance of nerve growth and the formation of plasticity of synapses, helping researchers better understand underlying mechanisms of neural circuit development and maintenance that may play a role in such human diseases/conditions as depression, anxiety, and pain Chapters make use of a variety of human and animal models, allowing researchers to compare and contrast neural circuitry development across a wide spectrum of models
The Coordination and Role of Activity in Developing Neural Circuits
Author: Bryce Thomas Bajar
Publisher:
Published: 2021
Total Pages: 246
ISBN-13:
DOWNLOAD EBOOK →The stereotyped synaptic connections that define neural circuit function are established during development. Neuronal activity independent of environmental stimulus contributes to neural circuit assembly in vertebrates, but its precise role remains an open question, particularly at the level of defined cell types. By contrast, invertebrate neurodevelopment was thought to proceed in the absence of such developmental activity. Here I show that developmental activity accompanies synaptogenesis in the Drosophila brain. Using Drosophila genetics, epifluorescence microscopy, two-photon microscopy, immunohistochemistry, and visual behavior, I characterize this developmental activity, determine its role in synapse formation, and identify regulatory mechanisms at the cellular and molecular level. This patterned-stimulus independent neural activity occurs in a brain-wide fashion, and is characterized by stereotyped oscillations and cellular dynamics that reflect synaptic connectivity. Activity patterns instruct synapse development in a cell-type-specific manner. A transient and genetically specified population of neurons propagates this activity throughout the brain. Glia participate with complementary cycles of activity in a cell-type-specific fashion, and astrocytes are necessary for activity to occur. These data indicate that developmental activity is an evolutionarily conserved and fundamental component of neural circuit assembly that is coordinated by multiple molecular and cellular mechanisms.
Neural Circuit and Cognitive Development
Author: Bin Chen
Publisher: Academic Press
Published: 2020-06-10
Total Pages: 670
ISBN-13: 0128144122
DOWNLOAD EBOOK →Neural Circuit and Cognitive Development, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume is devoted mainly to anatomical and functional development of neural circuits and neural systems and cognitive development. Understanding the critical role these changes play in neurodevelopment provides the ability to explore and elucidate the underlying causes of neurodevelopmental disorders and their effect on cognition. This series is designed to fill the knowledge gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms that control the assembly of neural circuits in specific regions of the nervous system and multiple aspects of cognitive development
Neuroscience and Neurotechnology of Neuronal Cell Surface Molecules in Neural Circuits
Author: Masahito Yamagata
Publisher: Frontiers Media SA
Published: 2021-08-05
Total Pages: 294
ISBN-13: 2889711498
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