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Studies on Hepatitis Viruses

Author: Satya Prakash Gupta

Publisher: Academic Press

Published: 2018-06-20

Total Pages: 242

ISBN-13: 0128133317

Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of viral hepatitis Presents an in-depth view of the structure and function of viral hepatitis Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models

Viral Hepatitis

Author: Arie J. Zuckerman

Publisher:

Published: 1993

Total Pages: 612

ISBN-13:

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Discusses all aspects of viral hepatitis, from structure and molecular virology, and natural history and experimental models, to epidemiology, diagnosis and prevention. A section on clinical aspects covers transfusion-associated hepatitis, occupational aspects and paediatric infection.

Guidelines on Hepatitis B and C Testing

Author: World Health Organization

Publisher: World Health Organization

Published: 2017

Total Pages: 0

ISBN-13: 9789241549981

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Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Hepatitis and Liver Cancer

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2010-05-23

Total Pages: 252

ISBN-13: 0309146283

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The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.

Hepatitis B Virus

Author: Haitao Guo

Publisher: Humana

Published: 2024-08-28

Total Pages: 0

ISBN-13: 9781071640265

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This detailed new edition collects state-of-the-art methods in the fields of hepatitis B virus (HBV) molecular biology and immunology. The book features techniques for cell culture, epigenetic regulation of cccDNA transcription, epitranscriptomic modification of HBV RNA, HBV pregenomic RNA and subviral particle morphogenesis, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hepatitis B Virus: Methods and Protocols, Second Edition serves as an ideal guide for researchers pursuing a cure for this chronic disease.

Eliminating the Public Health Problem of Hepatitis B and C in the United States

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-06-01

Total Pages: 187

ISBN-13: 0309438020

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Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Viral Hepatitis

Author: Howard C. Thomas

Publisher: John Wiley & Sons

Published: 2013-07-22

Total Pages: 645

ISBN-13: 111863733X

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The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV. The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in the case of hepatitis B, C and D may lead to severe complications including chronic hepatitis, cirrhosis and hepatocellular carcinoma. The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and International Health Authorities.

Viral Hepatitis: Chronic Hepatitis C

Author: Resat Ozaras

Publisher: Springer

Published: 2019-07-06

Total Pages: 0

ISBN-13: 9783030037567

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This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed, and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately, and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.

Research in Chronic Viral Hepatitis

Author: W.H. Gerlich

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 289

ISBN-13: 3709193125

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Chronic viral hepatitis remains one of the major medical problems worldwide. Neither a cure nor eradication of this disease is in sight. The chronic disease caused by hepatitis viruses type B, C and D is a much greater problem than the acute disease caused by the same viruses or by hepatitis viruses type A and E. Chronic viral hepatitis often remains unrecognized until the patient develops decompensated liver cirrhosis or hepatocellular carcinoma. Furthermore, unrecognized chronic virus carriers are a persistent source of infection by sexual and other close contacts as well as during many medical procedures. The viruses of chronic hepatitis are very different from each other from a taxonomical point of view, but they share many common pathogenic properties and they often coinfect individuals. Six years ago Carlo De Bac, Gloria Taliani (Rome) and I undertook an effort to bring together, under the auspices of the European Society against Virus Diseases, clinicians, laboratory physicians, epidemiologists, pathologists and molecular biologists whose primary research interest is chronic viral hepatitis. The contributions from these quite divergent participants to a meeting devoted solely to chronic viral hepatitis were most stimulating and valuable. As a result of the success of the first meeting in Fiuggi (Italy), a second followed in Siena (Italy) 1990 and the recent third meeting was held in Pisa (Italy). Most of the speakers expressed interest in publishing their contributions in the form of a proceedings volume, as was done in the case of the Siena meeting.

Viral Hepatitis Molecular Biology Diagnosis and Control

Author: Isa K. Mushahwar

Publisher: Gulf Professional Publishing

Published: 2004

Total Pages: 298

ISBN-13: 9780444514875

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The last forty years have witnessed the discovery of five human hepatitis viruses: hepatitis virus A, B, C, D, and E, and two related blood-borne viruses: GB virus C and TT virus. Viral Hepatitis provides a comprehensive overview of the latest developments and research studies in human viral hepatitis. Written by leading international scientists in the field, this book covers topics ranging from the history of these viruses to their molecular biology, diagnosis, epidemiology and control. It will be an invaluable reference source for hepatitis researchers, reference and diagnostic laboratories, clinicians, public health officers and graduate and medical students. Book jacket.