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Steroids and the Nervous System

Author: Cristin Roth

Publisher: American Medical Publishers

Published: 2023-09-19

Total Pages: 0

ISBN-13:

A biologically active organic compound with four rings arranged in a specific molecular configuration is termed as a steroid. Steroid hormones are essential for cell life and they affect the neuroendocrine and behavioral functions in humans. Steroids perform two main biological functions. The first function is that they form an essential part of cell membranes which alters the membrane fluidity. The second function is signal transduction or cell signaling that facilitates cellular response. During early development, steroids regulate the activity and plasticity of neurons and the glial cells. They continue to exert trophic and protective effects on the adult nervous system. Steroids are synthesized by the gonads and adrenal glands, and are transmitted to the brain, spinal cord and the peripheral nerves through the bloodstream. Neurosteroids such as pregnenolone, progesterone, dehydroepiandrosterone and sulfate esters are produced within the nervous system. This book unravels the recent studies related to the importance of steroids in the nervous system. The topics covered herein are of utmost significance and bound to provide incredible insights to the readers. Through this book, we attempt to further enlighten the readers about the new concepts in this field of study.

Steroids and the Nervous System

Author: GianCarlo Panzica

Publisher:

Published: 2003

Total Pages: 424

ISBN-13:

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This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.

Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2008

ISBN-13: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Steroids and the Nervous System

Author: GianCarlo Panzica

Publisher:

Published: 2011

Total Pages: 239

ISBN-13:

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Neurosteroids and the Nervous System

Author: Steven R. King

Publisher: Springer Science & Business Media

Published: 2012-11-09

Total Pages: 132

ISBN-13: 1461455596

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While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.

CNS Neurotransmitters and Neuromodulators

Author: Trevor W. Stone

Publisher: CRC Press

Published: 1996-03-27

Total Pages: 256

ISBN-13: 9780849376337

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As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.

Steroids in Diseases of the Central Nervous System

Author: Rudy Capildeo

Publisher:

Published: 1989-10-12

Total Pages: 328

ISBN-13:

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Outstanding contributions present an overview of steroids, starting with their molecular biology, pharmacology, and immunology. Steroids in Diseases of the Central Nervous System deals with the current applications of steroids in a variety of clinical conditions; treatments are described for brain tumors, malignant glioma, head and spinal damage, Guillain-Barré syndrome, polymyositis, and other neurological diseases.

Neurosteroid Effects in the Central Nervous System

Author: Sheryl S. Smith

Publisher: CRC Press

Published: 2003-10-27

Total Pages: 408

ISBN-13: 0203508165

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Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,

Steroids and Neuronal Activity

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

Published: 2008-04-30

Total Pages: 294

ISBN-13: 0470513993

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Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.

Neurosteroids

Author: Etienne-Emile Baulieu

Publisher: Springer Science & Business Media

Published: 1999-07-23

Total Pages: 404

ISBN-13:

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Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.