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Stem Cells and the Future of Regenerative Medicine

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2002-01-25

Total Pages: 112

ISBN-13: 0309170427

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Stem Cells: From Basic Research to Therapy, Volume Two

Author: Federico Calegari

Publisher:

Published: 2014

Total Pages: 474

ISBN-13: 9781306866637

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The second volume in the Stem Cells series concentrates on the mechanisms of stem cell regeneration in the adult organism with a view towards understanding how lost tissue can be replaced during adulthood and aging. The second focus of this volume is on stem cell identification and manipulation, including applications in basic research, medicine, and industry. The book closes with an outlook on generalized approaches that can be used to solve legislative and ethical challenges.

Stem Cells: From Basic Research to Therapy

Author: Federico Calegari

Publisher: CRC Press

Published: 2014-02-07

Total Pages: 672

ISBN-13: 1482207753

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The first volume of Stem Cells deals with the fundamental principles that govern embryonic and somatic stem cell biology. Historically, the identification and characterization of such pathways and general rules of stemness occurred during embryonic development and Volume I reflects this with topics spanning cell cycle regulation, epigenetics, and asymmetric cell division in a number of organ systems from planarian to human. Three specific sections discuss i) Basic Stem Cell Biology, ii) Tissue Formation During Development, and iii) Model Organisms with particular emphasis on those more relevant for biomedical research and, thus, leading to the topics addressed in Volume II.

Stem Cells: From Basic Research to Therapy, Volume Two

Author: Federico Calegari

Publisher: CRC Press

Published: 2014-06-03

Total Pages: 476

ISBN-13: 1482219832

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Cell Biology and Translational Medicine, Volume 5

Author: Kursad Turksen

Publisher: Springer

Published: 2019-05-31

Total Pages: 172

ISBN-13: 9783030175887

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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fifth volume of a continuing series.

Stem Cell Therapy for Vascular Diseases

Author: Tulio Pinho Navarro

Publisher: Springer Nature

Published: 2020-11-05

Total Pages: 425

ISBN-13: 3030569543

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Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Stem Cells in Regenerative Medicine

Author: Alain A. Vertes

Publisher: John Wiley & Sons

Published: 2015-12-02

Total Pages: 788

ISBN-13: 111997139X

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This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Cell Biology and Translational Medicine, Volume 11

Author: Kursad Turksen

Publisher: Springer Nature

Published: 2021-07-20

Total Pages: 181

ISBN-13: 3030719251

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Cell Biology and Translational Medicine, Volume 7

Author: Kursad Turksen

Publisher: Springer Nature

Published: 2020-02-03

Total Pages: 158

ISBN-13: 3030378454

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Stem Cell Biology and Gene Therapy

Author: Peter J. Quesenberry

Publisher: John Wiley & Sons

Published: 1998-09-10

Total Pages: 586

ISBN-13: 9780471146568

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STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.