Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed
Author: Amin Tamadon
Publisher: Frontiers Media SA
Published: 2022-03-16
Total Pages: 137
ISBN-13: 288974471X
DOWNLOAD EBOOK →Lanterna Rally
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Stem Cells
Author: Ariff Bongso
Publisher: World Scientific
Published: 2011
Total Pages: 721
ISBN-13: 9814289388
DOWNLOAD EBOOK →Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.
Microbial Metagenomics in Effluent Treatment Plant
Author: Maulin P. Shah
Publisher: Elsevier
Published: 2024-05-24
Total Pages: 290
ISBN-13: 0443135320
DOWNLOAD EBOOK →Microbial Metagenomics in Effluent Treatment Plant introduces a metagenomic approach characterizing microbial communities?in industrial wastewater treatment, providing an overall picture of metagenomics, its application, processes, and future prospects in the field of bioremediation. It also discusses culture-dependent methods, culture-independent methods, and?enzymatic methods?used to estimate bacterial diversity to monitor temporal and spatial changes in bacterial communities. In addition, a metagenomic approach will be discussed to characterize the microbial communities in industrial wastewater treatment. Researchers, scientists, professors, and students in environmental engineering, applied microbiology, and water treatment will find Microbial Metagenomics in Effluent Treatment Plant helpful in understanding the importance and role of metagenomics in biogeochemical cycles and degradation and detoxification of environmental pollutants. Presents text rich in information and knowledge of metagenomics Introduces novel and powerful insights into the already existing bioremediation process Serves as an easy-to-understand and centralized resource of information with practical application ideas
Fungal Primary and Secondary Metabolism and its Importance for Virulence and Biomedical Applications
Author: Fernando Rodrigues
Publisher: Frontiers Media SA
Published: 2021-06-23
Total Pages: 164
ISBN-13: 2889668894
DOWNLOAD EBOOK →Drug Discovery and Development, Third Edition
Author: James J. O'Donnell
Publisher: CRC Press
Published: 2019-12-13
Total Pages: 860
ISBN-13: 1351625136
DOWNLOAD EBOOK →Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business
Angiogenesis Assays
Author: Carolyn A. Staton
Publisher: John Wiley & Sons
Published: 2007-01-11
Total Pages: 410
ISBN-13: 047002934X
DOWNLOAD EBOOK →Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Adipose-Derived Stem Cells
Author: Jeffrey M. Gimble
Publisher: Humana Press
Published: 2011-08-24
Total Pages: 474
ISBN-13: 9781617379611
DOWNLOAD EBOOK →During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.
Extracellular Vesicle-Based Therapeutics
Author: Tushar Patel
Publisher: Academic Press
Published: 2022-10-15
Total Pages: 366
ISBN-13: 9780323902755
DOWNLOAD EBOOK →Extracellular Vesicles-Based Therapeutics presents the exciting prospect of targeted delivery of drugs through exosomes. Taking a critical perspective, the Editor gathered worldwide experts both in academia and corporate settings to cover all aspects of the subject, from fundamental biological aspects to scaling up production, and regulation. The book is structured in six sections, each covering a distinct topic. Within each section, the authors and chapters were selected to provide a balanced coverage. Section I deals with the fundamentals of EV biology: types, formation, interactions and effects. Section II covers Extracellular Vesicles (EVs) isolation, and purification approaches. Section III presents EV production platforms, providing a framework and guidelines by which clinically usable and consistent EV therapeutics could be manufactured. Section IV covers preclinical studies and applications, reviewing studies that provide opportunities to identify disease-relevant indications for EV therapeutics and to guide their translation to clinical trials. Section V presents drug development and commercialization of EV therapeutics, covering considerations in regulatory approvals and market access for EV based therapeutics. Section VI covers clinical trials of EV therapeutics, outlining a framework for clinical evaluation, including study design and clinical trials strategies and examples of on-going trials of EV-based therapeutics. Extracellular Vesicles-Based Therapeutics is a complete resource for researchers in this exciting area. Its breadth of coverage makes it particularly interesting to pharmaceutical researchers exploring the potential of this platform for targeted drug delivery. Physicians, Regulators, Laboratory directors and Industry executives in biotechnology would also benefit from the contents in this book. Offers a critical view into the potential use of Exosomes for therapeutic use Brings experts in academic and industry together to cover biological principles all the way to manufacturing Strong translational characteristics, taking research to practice Covers scaling up processes and regulation
Fabry Disease
Author: Deborah Elstein
Publisher: Springer Science & Business Media
Published: 2010-08-02
Total Pages: 525
ISBN-13: 9048190339
DOWNLOAD EBOOK →Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
Extracellular Vesicles
Author:
Publisher: Academic Press
Published: 2020-11-08
Total Pages: 314
ISBN-13: 0128206624
DOWNLOAD EBOOK →Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series
