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Author: Atefeh Zarepour
Publisher: Springer
Published: 2017-01-20
Total Pages: 53
ISBN-13: 9811035636
DOWNLOAD EBOOK →This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.
Author: Surender Kumar Sharma
Publisher: Springer Nature
Published: 2020-03-02
Total Pages: 495
ISBN-13: 3030399230
DOWNLOAD EBOOK →This book contains most updated information on synthesis of magnetic nanohybrids, their physio-chemical properties, and key biological applications. It highlights the complexity of nanoheterostructures, especially magnetic metal oxides, ferrites and doped magnetic nanomaterials, and discusses their potential applications in the early detection, imaging and treatment of cancer. It also covers the toxicity and risk assessment of multifunctional nanomaterials. Providing an overview of magnetic nanoheterostructures, it appeals to a wide audience, from beginners and graduate-level students to experts in academia and industry.
Author: Mahendra Rai
Publisher: Springer Nature
Published: 2019-11-22
Total Pages: 413
ISBN-13: 3030297683
DOWNLOAD EBOOK →This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.
Author: Patrick Couvreur
Publisher: World Scientific
Published: 2016-02-22
Total Pages: 346
ISBN-13: 9814713546
DOWNLOAD EBOOK →The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.
Author: Costica Caizer
Publisher: John Wiley & Sons
Published: 2021-09-08
Total Pages: 512
ISBN-13: 1119754747
DOWNLOAD EBOOK →Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Author: Zachary R. Stephen
Publisher:
Published: 2016
Total Pages: 135
ISBN-13:
DOWNLOAD EBOOK →Nanotechnology has given scientists new tools for the development of advanced materials for the detection, diagnosis and treatment of disease. Superparamagnetic iron oxide nanoparticles (SPIONs) in particular have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties that allow modification for improved in vivo kinetics and multifunctionality. SPIONs favorable characteristics have further led to their investigation as promising theranostic agents, which combine imaging and therapeutic capabilities in a single nanovector. The combination of imaging and therapy could allow for real-time monitoring of drug delivery and the tailoring of treatment for individual patients with the promise of improved clinical outcomes for patients suffering from cancers such as glioblastoma (GBM). This dissertation is intended to address limitation of conventional clinical cancer treatment including current cancer targeting limitations and poor pharmacokinetic of hydrophobic chemotherapeutics that lead to unacceptable side effects. First, SPIONs were coated with cross-linked, redox-responsive copolymers composed of chitosan and polyethylene glycol (PEG), functionalized with cancer targeting agent chlorotoxin (CTX), and modified with O6-benzylguanine (BG), an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor to improve temozolomide based treatments of GBMs. It was found that CED of the BG loaded SPION were more tolerable than free drug and increased survival 3-fold over untreated animals in an intracranial GBM mouse model. Next, analogs of BG were evaluated for their inhibitory efficacy and modified to allow for polymerization on the SPION surface via hydrazone linkages to facilitate improved drug loading and controlled drug release. Finally, a new synthesis and functionalization strategy for theranostic agents is presented that demonstrated streamlined production, allowed for great control over the display of functional moieties on the SPION surface, increased batch to batch consistency, and provided improved magnetic properties.
Author: Xiaoyuan Chen
Publisher: Academic Press
Published: 2014-03-20
Total Pages: 543
ISBN-13: 0124078842
DOWNLOAD EBOOK →Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management
Author: Mohindar Seehra
Publisher: BoD – Books on Demand
Published: 2017-07-12
Total Pages: 225
ISBN-13: 9535133713
DOWNLOAD EBOOK →There continues to be a worldwide interest in the size-dependent properties of nanostructured materials and their applications in many diverse fields such as catalysis, sensors, energy conversion processes, and biomedicine to name a few. The eleven chapters of this book written by different researchers include four chapters on the different methods of fabrication of specific materials followed by characterization of their properties, and the remaining seven chapters focusing on the fabrications and applications including three chapters on biomedical applications, two chapters on sensors, one chapter on solar cells, and one chapter on the use of nanoparticles in herbicides. These chapters provide up-to-date reviews useful for current and future researchers in these specific areas.
Author: Keerti Jain
Publisher: Springer Nature
Published: 2023-08-23
Total Pages: 417
ISBN-13: 9819905389
DOWNLOAD EBOOK →This book discusses approaches based on multifunctional and targeted theranostic nanomedicines for improving diagnosis and drug delivery. It explores nanomedicines based on nanocarriers like liposomes, ethosomes, niosomes, polymeric nanoparticles, lipidic nanoparticles, metallic nanoparticles, micelles, dendrimers, quantum dots, carbon-based nanomaterials including carbon nanotubes, carbon dots, carbon quantum dots, graphene oxide, and fullerene. This book reviews designing, conjugation, optimization, formulation and development, and scale-up of multifunctional and targeted theranostic nanomedicines. It examines major challenges in developing nanomaterials that can be applied to nanomedicine with high biocompatibility and biodegradability for diagnostic and therapeutic purposes. Lastly, it addresses the most promising approaches at both commercialization and regulatory steps for bringing theranostic nanomedicine from research laboratories to clinics for patient use.
Author:
Publisher: Academic Press
Published: 2018-06-23
Total Pages: 222
ISBN-13: 0128141700
DOWNLOAD EBOOK →Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
