The Politics of Sickle Cell and Thalassaemia

The Politics of Sickle Cell and Thalassaemia PDF

Author: Elizabeth N. Anionwu

Publisher:

Published: 2001

Total Pages: 184

ISBN-13:

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Sickle cell disorder (SCD) and thalassaemia are inherited blood disorders which have only recently gained serious attention among health professionals and policy makers. In this text, Anionwu (nursing, Thames Valley U.) and Atkin (U. of Leeds) explore issues regarding these disorders in the UK, and the broader problems faced by minority ethnic communities in acquiring adequate health care and support. Coverage includes a clinical introduction to haemoglobinopathies; screening and diagnosing within the context of the "new genetics," including associated ethical dilemmas and problems; general problems faced by patients and their families, and their daily coping strategies; current shortfalls in providing care; examples of existing good practice; strategies and struggles from the historical development of haemoglobinopathy services in the UK; and opportunities and threats for the future. c. Book News Inc.

Disorders of Hemoglobin

Disorders of Hemoglobin PDF

Author: Martin H. Steinberg

Publisher: Cambridge University Press

Published: 2009-08-17

Total Pages: 883

ISBN-13: 0521875196

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Completely revised new edition of the definitive reference on disorders of hemoglobin.

Genetics and Global Public Health

Genetics and Global Public Health PDF

Author: Simon M. Dyson

Publisher: Routledge

Published: 2014-06-11

Total Pages: 221

ISBN-13: 1317977424

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Sickle cell and thalassaemia are among the world’s most common genetic conditions. They are especially common in Africa, Brazil, the Caribbean, the Middle East and Asia. They affect all ethnic groups but they particularly impact on minority ethnic groups in North America, Europe and Australasia. Much research has focused on clinical, laboratory and genetic studies of these conditions. Through a wide-ranging selection of readings based on social scientific research into sickle cell and thalassaemia, this book seeks to redress this imbalance. This is important as, through an examination of the different social, economic and cultural contexts of the lives of people living with sickle cell or thalassaemia, the contributors demonstrate that people are more than the sum of their genes and that their life experiences are rarely derived solely from the clinical severity of their condition but depend on the social context of their lives. Genetics and Global Public Health presents a new concluding chapter which highlights the critical nature of social science research for sickle cell and thalassaemia communities, providing key insights into the social contexts of human behaviour and analysing how societal arrangements could change to assist people living with either condition. It will be of great interest to postgraduate and research students as well as professionals working in the field of public health. This book was originally published as a special issue of the journal Ethnicity and Health.

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies

Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies PDF

Author: Stephan Lobitz

Publisher: MDPI

Published: 2019-10-07

Total Pages: 160

ISBN-13: 3039216147

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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.

Inherited Hemoglobin Disorders

Inherited Hemoglobin Disorders PDF

Author: Anjana Munshi

Publisher: BoD – Books on Demand

Published: 2015-11-11

Total Pages: 198

ISBN-13: 9535121987

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The book, Inherited Hemoglobin Disorders, describes the genetic defects of hemoglobins, disease complications, and therapeutic strategies. This book has two distinct sections. The first theme includes seven chapters devoted to the types of hemoglobinopathies, mutation spectrum, diagnostic methods, and disease complications, and the second theme includes three chapters focusing on various treatment strategies. The content of the chapters presented in the book is guided by the knowledge and experience of the contributing authors. This book serves as an important resource and review to the researchers in the field of hemoglobinopathies.

Gene and Cell Therapies for Beta-Globinopathies

Gene and Cell Therapies for Beta-Globinopathies PDF

Author: Punam Malik

Publisher: Springer

Published: 2017-11-09

Total Pages: 248

ISBN-13: 1493972995

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Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HS CT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.

Ethnicity and Screening for Sickle Cell/thalassaemia

Ethnicity and Screening for Sickle Cell/thalassaemia PDF

Author: Simon Dyson

Publisher: Churchill Livingstone

Published: 2005

Total Pages: 220

ISBN-13:

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Screening policies for sickle cell and thalassaemia have only recently been formalized in the UK. This book asks what types of ethnicity information are relevant for health professionals to ask as part of this screening and why. Through extensive use of interview material, the book draws upon the experiences of sickle cell and thalassaemia counsellors who have been at the forefront of understanding in this area. The book: . Demonstrates how best practice for screening in a multi-ethnic society requires us to better understand the myth of 'races', the meanings of concepts such as ethnicity and racialization, and the relation of racism to issues of citizenship, immigration, asylum and nationality. . Shows how learning from best practice for screening could be a model for developing cultural competency across all types of health care provision. . Clarifies, through the use of the biologically-grounded exemplar of sickle cell and thalassaemia, debates of 'race' and ethnicity for those working in social sciences. . Listens to the voices of experience and validates the hitherto unacknowledged achievements of professional women from minoritized ethnic groups. Extensive direct quotations from experienced sickle cell and thalassemia counsellors Explanations of key concepts, such as 'race', ethnicity and racism Explanation of the political, social and historical factors underlying tensions in asking an ethnicity questions Further resources and website information

The Obstetric Hematology Manual

The Obstetric Hematology Manual PDF

Author: Sue Pavord

Publisher: Cambridge University Press

Published: 2018-02-08

Total Pages: 362

ISBN-13: 1108548377

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Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.

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