Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity PDF

Author: Franck Mauvais-Jarvis

Publisher: Springer

Published: 2017-12-08

Total Pages: 627

ISBN-13: 3319701789

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The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Metabolic Cardiomyopathy

Metabolic Cardiomyopathy PDF

Author: H. Böhles

Publisher: CRC Press

Published: 2004

Total Pages: 188

ISBN-13: 9783887631048

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During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Pancreatic Islet Biology

Pancreatic Islet Biology PDF

Author: Anandwardhan A. Hardikar

Publisher: Springer

Published: 2016-10-25

Total Pages: 324

ISBN-13: 3319453076

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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.

Fearless Feeding

Fearless Feeding PDF

Author: Jill Castle

Publisher: John Wiley & Sons

Published: 2013-04-12

Total Pages: 343

ISBN-13: 1118421558

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An essential guide to understanding and improving any child's eating habits This comprehensive nutrition guide gives parents the tools for encouraging kids of any age on the path to healthy eating. Pediatric nutrition experts Castle and Jacobsen simplify nutrition information, describe how children's eating habits correspond to their stage of development, provide step-by-step feeding guidance, and show parents how to relax about feeding their kids and get healthy meals on the table fast. Prepares parents by explaining what to expect at different stages of growth, whether it be picky eating, growth spurts or poor body image Helps parents work through problems such as food allergies, nutrient deficiencies and weight management, and identifying if and when they need to seek professional help Empowers parents to take a whole-family approach to feeding including maximizing their own health and well-being Offers fun, easy recipes parents can make for, and with, kids Fearless Feeding translates complicated nutrition advice into simple feeding plans for every age and stage that take the fear out of feeding kids.

Taste, Nutrition and Health

Taste, Nutrition and Health PDF

Author: Beverly J. Tepper

Publisher: MDPI

Published: 2020-06-25

Total Pages: 350

ISBN-13: 3039284444

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The sensation of flavor reflects the complex integration of aroma, taste, texture, and chemesthetic (oral and nasal irritation cues) from a food or food component. Flavor is a major determinant of food palatability—the extent to which a food is accepted or rejected—and can profoundly influence diet selection, nutrition, and health. Despite recent progress, gaps in knowledge still remain regarding how taste and flavor cues are detected at the periphery, conveyed by the brainstem to higher cortical levels, and then interpreted as a conscious sensation. Taste signals are also projected to central feeding centers where they can regulate hunger and fullness. Individual differences in sensory perceptions are also well known and can arise from genetic variation, environmental causes, or a variety of metabolic diseases, such as obesity, metabolic syndrome, and cancer. Genetic taste/smell variation could predispose individuals to these same diseases. Recent findings have opened new avenues of inquiry, suggesting that fatty acids and carbohydrates may provide nutrient-specific signals informing the gut and brain of the nature of the ingested nutrients. This Special Issue, Taste, Nutrition, and Health, presents original research communications and comprehensive reviews on topics of broad interest to researchers and educators in sensory science, nutrition, physiology, public health, and health care.

Global Health Complications of Obesity

Global Health Complications of Obesity PDF

Author: Jahangir Moini

Publisher: Elsevier

Published: 2020-04-01

Total Pages: 482

ISBN-13: 0128197528

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Global Health Complications of Obesity presents a valuable resource for research scientists and clinicians by covering the burden of obesity and related diseases and serving as a starting point for in-depth discussions in academic settings and for obesity-treatment specialists. Obesity is associated with a statistically higher risk of heart disease, hypertension, insulin resistance, type 2 diabetes and many other diseases. This succinct resource focuses on the current data, research and management of obesity. It is essential reading for healthcare professionals, endocrinologists, nutritionists, public health students and medical students. Presents clinical cases, key terms and targeted references Addresses diseases including diabetes, cancer, hypertension, osteoarthritis, fatty liver disease, infertility, renal failure and depression Provides a link to new knowledge that is ideal for both researchers and clinicians

Hyperandrogenism in Women

Hyperandrogenism in Women PDF

Author: R. Pasquali

Publisher: Karger Medical and Scientific Publishers

Published: 2019-09-09

Total Pages: 201

ISBN-13: 3318064718

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Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.

Sex and Gender Effects in Pharmacology

Sex and Gender Effects in Pharmacology PDF

Author: Stella E. Tsirka

Publisher: Springer Nature

Published: 2023-11-12

Total Pages: 286

ISBN-13: 3031426487

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Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

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