Serine Proteases and Their Serpin Inhibitors in the Nervous System, Regulation in Development and in Degenerative and Malignant Disease

Serine Proteases and Their Serpin Inhibitors in the Nervous System, Regulation in Development and in Degenerative and Malignant Disease PDF

Author: Barry W. Festoff

Publisher:

Published: 1990

Total Pages: 382

ISBN-13:

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A NATO Advanced Research Workshop was held on the topic of the possible roles and regulation of serine proteases and their high molecular weight inhibitors, the serpins, in the nervous system. Some of the topics covered in this workshop include: Biochemistry and cell biology; Thrombin structural regions in determining bioregulatory functions; Main components of the fibrinolytic system (i.e. plasmin); Inhibitors of the fibrinolytic system; Regulation and control of physiological fibrinolysis; A key molecule dictating and regulating surface plasmin formation; Regulation of tissue plasminogen activator secretion from human endothelial cells, Thrombin disintegrates cell surface urokinase focal adhesion plaques and decreases cell extension; The heparin binding site and activation of protease nexin 1; Peptide hydrolases; Fibroblasts accelerate the inactivation of thrombin by PNI; Fibroblasts block the ability of PNI to inactivate urokinase and plasmin; Use of protein chemistry and molecular biology to determine interaction areas between proteases and their inhibitors; Signal transduction chains involved in the control of the fibrinolytic enzyme cascade; Structure of the human protease nexin gene and expression of recombinant forms of PNI; Serine proteases in the nervous system; and Serpins in degenerative and malignant neurologic diseases.

Proteases in Human Diseases

Proteases in Human Diseases PDF

Author: Sajal Chakraborti

Publisher: Springer

Published: 2017-07-13

Total Pages: 513

ISBN-13: 9811031622

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This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Current Catalog

Current Catalog PDF

Author: National Library of Medicine (U.S.)

Publisher:

Published: 1991

Total Pages: 700

ISBN-13:

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First multi-year cumulation covers six years: 1965-70.

Brain Tumor Invasiveness

Brain Tumor Invasiveness PDF

Author: Ronald H. Goldfarb

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 186

ISBN-13: 1461526221

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It is widely appreciated that the pathophysiology of advanced brain cancer is intimately related to the extent of tumor invasiveness. A prerequisite for comprehensively understanding neuro-oncology is therefore the elucidation of the biochemical and molecular properties of tumor cells that contribute to their invasiveness. An understanding of tumor invasion for central nervous system tumors is crucial since malignant brain tumors are very highly invasive and extensively destroy adjacent neural brain tissue. Moreover, they are angiogenesis-dependent and lead to the death of patients by expanding within the limited space of the cranium. As more specific insights are gained towards a full understanding of the complex process of tumor invasiveness of brain tumor cells, it should be possible to design strategies for the early diagnosis and treatment of invasive, advanced brain tumors. There is therefore an urgent need to better understand the cellular properties of brain tumor cells responsible for invasiveness. This special issue of the JOURNAL OF NEURO-ONCOLOGY provides a state-of-the-art review of the general understanding of the process of tumor invasion. In addition, the articles emphasize specific aspects of aggressive brain cancers which are particularly important for deriving new insights for therapeutic approaches for advanced brain cancer that will target tumor invasiveness. The ideas discussed will stimulate further studies directed towards the translation of these important invasion-related studies to clinical approaches for the effective treatment of brain cancer.

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