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Scale-Up Processes

Author: Jamal Chaouki

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2021-09-20

Total Pages: 350

ISBN-13: 3110713985

Common scale-up methods are conventional where the blind piloting is essential. This imposes huge investment and leads to failures mostly in solid processing. However, the limitations of resources, current shortcomings, short time-to-market demand are forced companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences:

Industrial Process Scale-up

Author: Jan Harmsen

Publisher: Elsevier

Published: 2013-04-25

Total Pages: 129

ISBN-13: 0444627391

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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen

Publisher: Editions TECHNIP

Published: 1993

Total Pages: 266

ISBN-13: 9782710806462

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Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

Published: 2006-08-21

Total Pages: 296

ISBN-13: 3527607765

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Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Chemical Engineering in the Pharmaceutical Industry

Author: Mary T. am Ende

Publisher: John Wiley & Sons

Published: 2019-04-08

Total Pages: 1435

ISBN-13: 111928550X

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A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Biopharmaceutical Processing

Author: Gunter Jagschies

Publisher: Elsevier

Published: 2018-01-18

Total Pages: 1308

ISBN-13: 0128125527

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Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference

Scaleup of Chemical Processes

Author: Attilio Bisio

Publisher: Wiley-Interscience

Published: 1985-07-25

Total Pages: 760

ISBN-13:

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The focus of this book is on the technical factors that are critical to th e design and startup of a commercial manufacturing facility.

Advances in Life Cycle Engineering for Sustainable Manufacturing Businesses

Author: Shozo Takata

Publisher: Springer Science & Business Media

Published: 2007-07-26

Total Pages: 474

ISBN-13: 1846289351

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Life cycle engineering explores technologies for shifting industry from mass production and consumption paradigms to closed-loop manufacturing paradigms, in which required functions are provided with the minimum amount of production. This subject is discussed from various aspects: life cycle design, design for environment, reduce-reuse-recycle, life cycle assessment, and sustainable business models. This book collects papers from the 14th International CIRP Life Cycle Engineering Conference, the longest-running annual meeting in the field.

Chemical Projects Scale Up

Author: Joe M. Bonem

Publisher: Elsevier

Published: 2018-05-31

Total Pages: 232

ISBN-13: 0128137282

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Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Recent Advances in Biotechnology

Author: F. Vardar-Sukan

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 554

ISBN-13: 940112468X

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In last decades rapid scientific and engineering developments have been occuring within the context of Biotechnology. If the World Economy is to benefit fully from the advances in biosciences and biochemical engineering, it must be able to focus new knowledge on commercially appropriate targets. Modern Biotechnology is a mixture of far reaching innovation superimposed on an industrial background and it represents a means of production with bright prospects, challenging problems and stimulating competition. This NATO Advanced Study Institute on "RECENT ADVANCES IN INDUSTRIAL APPLICATIONS OF BIOTECHNOLOGY" held between September 16-27, 1991 in Ku§Etdasl was the first ASI on Biotechnology :Ln Turkey. !t was aiming to provide an updated overview of the fundamental principles, novel application areas and impact of Biotechnology on international economy. Recent developments in the field of Biotechnology have been thoroughly discussed, concentrating on various interdisciplinary aspects. The illain lectures presented at the Institute covered both scientific and commercial aspects of new developments in biotechnology and discussed the possible ways of meeting the challenges of the industry. The main lectures were supplemented by Oral 2nd Poster Presentations. Thus, this volume is comprised of three sections. Part I contains the i~vited lectures and Part II oral presentations. Exte~ded abstracts of poster presentations have been included in Part III to provide a more comprehensive coverage of the ASI.