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SAS Graphics for Clinical Trials by Example

Author: Kriss Harris

Publisher: SAS Institute

Published: 2020-11-25

Total Pages: 198

ISBN-13: 195236597X

Create industry-compliant graphs with this practical guide for professionals Analysis of clinical trial results is easier when the data is presented in a visual form. However, clinical graphs must conform to specific guidelines in order to satisfy regulatory agency requirements. If you are a programmer working in the health care and life sciences industry and you want to create straightforward, visually appealing graphs using SAS, then this book is designed specifically for you. Written by two experienced practitioners, the book explains why certain graphs are requested, gives the necessary code to create the graphs, and shows you how to create graphs from ADaM data sets modeled on real-world CDISC pilot study data. SAS Graphics for Clinical Trials by Example demonstrates step-by-step how to create both simple and complex graphs using Graph Template Language (GTL) and statistical graphics procedures, including the SGPLOT and SGPANEL procedures. You will learn how to generate commonly used plots such as Kaplan-Meier plots and multi-cell survival plots as well as special purpose graphs such as Venn diagrams and interactive graphs. Because your graph is only as good as the aesthetic appearance of the output, you will learn how to create a custom style, change attributes, and set output options. Whether you are just learning how to produce graphs or have been working with graphs for a while, this book is a must-have resource to solve even the most challenging clinical graph problems.

Clinical Graphs Using SAS

Author: Sanjay Matange

Publisher: SAS Institute

Published: 2016-03-21

Total Pages: 270

ISBN-13: 1629602078

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SAS users in the Health and Life Sciences industry need to create complex graphs to analyze biostatistics data and clinical data, and they need to submit drugs for approval to the FDA. Graphs used in the HLS industry are complex in nature and require innovative usage of the graphics features. Clinical Graphs Using SAS® provides the knowledge, the code, and real-world examples that enable you to create common clinical graphs using SAS graphics tools, such as the Statistical Graphics procedures and the Graph Template Language. This book describes detailed processes to create many commonly used graphs in the Health and Life Sciences industry. For SAS® 9.3 and SAS® 9.4 it covers many improvements in the graphics features that are supported by the Statistical Graphics procedures and the Graph Template Language, many of which are a direct result of the needs of the Health and Life Sciences community. With the addition of new features in SAS® 9.4, these graphs become positively easy to create. Topics covered include the usage of SGPLOT procedure, the SGPANEL procedure and the Graph Template Language for the creation of graphs like forest plots, swimmer plots, and survival plots.

Statistical Graphics Procedures by Example

Author: Sanjay Matange

Publisher: SAS Institute

Published: 2014-11-29

Total Pages: 370

ISBN-13: 1607648873

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Sanjay Matange and Dan Heath's Statistical Graphics Procedures by Example: Effective Graphs Using SAS shows the innumerable capabilities of SAS Statistical Graphics (SG) procedures. The authors begin with a general discussion of the principles of effective graphics, ODS Graphics, and the SG procedures. They then move on to show examples of the procedures' many features. The book is designed so that you can easily flip through it, find the graph you need, and view the code right next to the example. Among the topics included are how to combine plot statements to create custom graphs; customizing graph axes, legends, and insets; advanced features, such as annotation and attribute maps; tips and tricks for creating the optimal graph for the intended usage; real-world examples from the health and life sciences domain; and ODS styles. The procedures in Statistical Graphics Procedures by Example are specifically designed for the creation of analytical graphs. That makes this book a must-read for analysts and statisticians in the health care, clinical trials, financial, and insurance industries. However, you will find that the examples here apply to all fields. This book is part of the SAS Press program.

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Author: Glenn Walker

Publisher: SAS Institute

Published: 2010-02-15

Total Pages: 553

ISBN-13: 1607644258

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Glenn Walker and Jack Shostak's Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is a thoroughly updated edition of the popular introductory statistics book for clinical researchers. This new edition has been extensively updated to include the use of ODS graphics in numerous examples as well as a new emphasis on PROC MIXED. Straightforward and easy to use as either a text or a reference, the book is full of practical examples from clinical research to illustrate both statistical and SAS methodology. Each example is worked out completely, step by step, from the raw data. Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is an applications book with minimal theory. Each section begins with an overview helpful to nonstatisticians and then drills down into details that will be valuable to statistical analysts and programmers. Further details, as well as bonus information and a guide to further reading, are presented in the extensive appendices. This text is a one-source guide for statisticians that documents the use of the tests used most often in clinical research, with assumptions, details, and some tricks--all in one place. This book is part of the SAS Press program.

Analysis of Clinical Trials Using SAS

Author: Alex Dmitrienko

Publisher: SAS Institute

Published: 2017-07-17

Total Pages: 455

ISBN-13: 1635261449

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Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.

Common Statistical Methods for Clinical Research with SAS Examples

Author: Glenn A. Walker

Publisher: Sas Inst

Published: 2002

Total Pages: 464

ISBN-13: 9781590470404

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This updated edition provides clinical researchers with an invaluable aid for understanding the statistical methods cited most frequently in clinical protocols, statistical analysis plans, clinical and statistical reports, and medical journals. The text is written in a way that takes the non-statistician through each test using examples, yet substantive details are presented that benefit even the most experienced data analysts.

Applied Medical Statistics Using SAS

Author: Geoff Der

Publisher: CRC Press

Published: 2012-10-01

Total Pages: 539

ISBN-13: 1439867984

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Written with medical statisticians and medical researchers in mind, this intermediate-level reference explores the use of SAS for analyzing medical data. Applied Medical Statistics Using SAS covers the whole range of modern statistical methods used in the analysis of medical data, including regression, analysis of variance and covariance, longitudi

Implementing CDISC Using SAS

Author: Chris Holland

Publisher: SAS Institute

Published: 2019-05-30

Total Pages: 294

ISBN-13: 1642952419

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For decades researchers and programmers have used SAS to analyze, summarize, and report clinical trial data. Now Chris Holland and Jack Shostak have updated their popular Implementing CDISC Using SAS, the first comprehensive book on applying clinical research data and metadata to the Clinical Data Interchange Standards Consortium (CDISC) standards. Implementing CDISC Using SAS: An End-to-End Guide, Revised Second Edition, is an all-inclusive guide on how to implement and analyze the Study Data Tabulation Model (SDTM) and the Analysis Data Model (ADaM) data and prepare clinical trial data for regulatory submission. Updated to reflect the 2017 FDA mandate for adherence to CDISC standards, this new edition covers creating and using metadata, developing conversion specifications, implementing and validating SDTM and ADaM data, determining solutions for legacy data conversions, and preparing data for regulatory submission. The book covers products such as Base SAS, SAS Clinical Data Integration, and the SAS Clinical Standards Toolkit, as well as JMP Clinical. Topics included in this edition include an implementation of the Define-XML 2.0 standard, new SDTM domains, validation with Pinnacle 21 software, event narratives in JMP Clinical, STDM and ADAM metadata spreadsheets, and of course new versions of SAS and JMP software. The second edition was revised to add the latest C-Codes from the most recent release as well as update the make_define macro that accompanies this book in order to add the capability to handle C-Codes. The metadata spreadsheets were updated accordingly. Any manager or user of clinical trial data in this day and age is likely to benefit from knowing how to either put data into a CDISC standard or analyzing and finding data once it is in a CDISC format. If you are one such person--a data manager, clinical and/or statistical programmer, biostatistician, or even a clinician--then this book is for you.

Modern Approaches to Clinical Trials Using SAS

Author: Sandeep Menon

Publisher: SAS Institute

Published: 2015-12-09

Total Pages: 482

ISBN-13: 1629600822

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Get the tools you need to use SAS® in clinical trial design! Unique and multifaceted, Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods, edited by Sandeep M. Menon and Richard C. Zink, thoroughly covers several domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods that are applicable to and widely used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, the book touches on a wide variety of topics, including dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs that incorporate historical data; adaptive sample size re-estimation; adaptive randomization to allocate subjects to more effective treatments; and population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology, and rheumatology. Individual chapters are authored by renowned contributors, experts, and key opinion leaders from the pharmaceutical/medical device industry or academia. Numerous real-world examples and sample SAS code enable users to readily apply novel clinical trial design and analysis methodologies in practice.

Analysis of Clinical Trials Using SAS

Author: Alex Dmitrienko

Publisher: SAS Institute

Published: 2017-07-17

Total Pages: 410

ISBN-13: 1635261465

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