Annual Report
Author: Maine State Pomological Society
Publisher:
Published: 1889
Total Pages: 160
ISBN-13:
DOWNLOAD EBOOK →Author: Maine State Pomological Society
Publisher:
Published: 1889
Total Pages: 160
ISBN-13:
DOWNLOAD EBOOK →Author: Maine. Board of Agriculture
Publisher:
Published: 1883
Total Pages: 476
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DOWNLOAD EBOOK →Author: Maine. Dept. of Agriculture
Publisher:
Published: 1887
Total Pages: 702
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DOWNLOAD EBOOK →Author: Maine. Commissioner of Agriculture
Publisher:
Published: 1888
Total Pages: 436
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DOWNLOAD EBOOK →Author: Gül Dölen
Publisher: Frontiers Media SA
Published: 2016-08-15
Total Pages: 183
ISBN-13: 2889199053
DOWNLOAD EBOOK →The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients.
Author: Maine State pomological Society
Publisher:
Published: 1883
Total Pages: 136
ISBN-13:
DOWNLOAD EBOOK →Author: Maine State Pomological Society
Publisher:
Published: 1877
Total Pages: 696
ISBN-13:
DOWNLOAD EBOOK →Author: Laurence Higgins
Publisher: Arena books
Published: 2010-12-12
Total Pages: 93
ISBN-13: 1909421456
DOWNLOAD EBOOK →This enjoyable and humorous fantasy follows the adventures of Laurence, a Master Magician, Elizabeth his wife, an Elfin Queen, who is also a White Witch, and their twins, Victoria and Matthew, both of whom are junior magicians.To help Laurence, Bern, a Cornish Pixie, Patrick, a Leprechaun, along with their steeds, two very clever Guinea Pigs, come to his aid. Independently Laurence and Elizabeth enter the Demon Dimension. Both have to defeat the Guardian of the Gateway into the land, the Demons fiercest fighter, and decide whether to help the slave races none of which are human!Meanwhile Victoria and Matthew find a huge egg which when hatched produces twin dragons. The Dragons, who have inherited memory, tell Victoria and Matthew about Dragon history. The two sets of twins embark on an adventure to challenge the Leader of the dragons, The Serpent King, who live on Titan (One of the Moons of Saturn).The adventures take all of them through a very very strange forest (The Pingdom) which is controlled by a wise Time Wizard. Laurence and Elizabeth must defeat two terrible Demon Wizards 'The Beast' and 'Small' before peace can be restored and nothing can be taken for granted!To stop a war, a duel is undertaken which is in four parts. They take Laurence to Prehistoric times, the future, the undergrowth (by shrinking) and the Arctic Wastelands. Things do not go according to the rules!The Demons did not however take into account that Laurence and Elizabeth would at the end have the help of their children who bring along some new found friends to help them.
Author: Urszula Demkow
Publisher: Academic Press
Published: 2015-09-10
Total Pages: 336
ISBN-13: 0128018410
DOWNLOAD EBOOK →Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients. The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia. Fills the gap between state-of-the-art technology and evidence-based practice Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment Promotes a practical tool that clinicians can apply directly to patient care Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases Presents evidence regarding the important role of NGS in current diagnostic strategies