-PDF Download- Regulation Of Red Cell Life Span Erythropoiesis Senescence And Clearance EBOOK

Regulation of red cell life-span, erythropoiesis, senescence and clearance

Author: Lars Kaestner

Publisher: Frontiers E-books

Published: 2014-12-03

Total Pages: 118

ISBN-13: 2889193489

Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

The Red Cell Life-Cycle From Erythropoiesis to Clearance

Author: Lars Kaestner

Publisher: Frontiers Media SA

Published: 2019-02-05

Total Pages: 238

ISBN-13: 2889457028

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The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.

Red Cell Membrane Transport in Health and Disease

Author: Ingolf Bernhardt

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 761

ISBN-13: 3662051818

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51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

The Ageless Body

Author: Peta Bee

Publisher: Bloomsbury Publishing

Published: 2015-12-31

Total Pages: 281

ISBN-13: 1472924436

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Discover the new goals and new rules that are the route to a healthier, better looking and better functioning body... for life! From Gwen Stefani and Cameron Diaz to Jennifer Aniston and Naomi Watts, a new breed of 40 and 50 plus women are redefining not just what an ageless body looks like, but what's entailed in achieving it. A dramatic shift in body expectations in the last few years means that, despite being plagued by a slowing metabolism and a naturally-occurring loss of muscle mass, pre- and post-menopausal women can realistically aim for the healthy, well-functioning body they crave as well as a physique that looks good with a flat stomach and sculpted arms. Peta Bee and Dr Sarah Schenker are the living embodiment of this new breed of woman: both in their forties with children, both with hectic careers and social lives. And both with the same bodies they had in their 30s. What matters, they have discovered through self-experimentation and trawling the scientific literature, is how you go about holding back the years. And the rules - for both exercise and diet - have changed.

Anemia in the Elderly

Author: Lodovico Balducci

Publisher: Springer Science & Business Media

Published: 2007-10-04

Total Pages: 148

ISBN-13: 0387495061

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Anemia in the elderly has been properly defined as the silent epidemic, representing 3 million people in the United States aged 65 years and older. Incidence and prevalence of this condition increase with age. It differs in its etiology, pathogenesis and treatment from anemia in children and younger adults. Anemia is associated with reduced survival, increased risk of functional dependence and hospitalization, increased risk of congestive heart failure and stage renal disease and cognitive disorders. Approximately 70% of anemia in older individuals is reversible.

Transfusion Medicine and Scientific Developments

Author: A.W.M.M. Koopman-van Gemert

Publisher: BoD – Books on Demand

Published: 2017-07-05

Total Pages: 130

ISBN-13: 9535133195

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Transfusion Medicine and Scientific Developments focuses on unknown aspects of blood cells and transfusion practice. Blood transfusion medicine has become a sophisticated and specialized field of medicine. Some aspects will be discussed in this book. The book has been divided into three sections. The first section includes chapters describing the immunological and coagulation-assisting functions of red blood cells and methods to measure their life span. The second section discusses the role of platelets in inflammatory processes. The third section reviews functional dose of RBC transfusions and transfusion practice in various clinical settings.

Notes on Knowledge, Indifference and Redundancy

Author: Esteban Céspedes

Publisher: Cambridge Scholars Publishing

Published: 2017-05-11

Total Pages: 150

ISBN-13: 144389334X

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What is knowledge? In what sense is the environment of a cognitive system more than a mere source of information? What are the roles of relevance and indifference for a characterisation of knowledge? How are knowledge and action related? These issues are considered and discussed in this book. Although it does not offer an account of knowledge, this work addresses a diverse range of important topics concerning that notion, seeking to connect them in a unifying way.

Naturally Occurring Antibodies (NAbs)

Author: Hans U. Lutz

Publisher: Springer Science & Business Media

Published: 2012-08-19

Total Pages: 285

ISBN-13: 1461434610

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This volume illustrates the functional properties of NAbs. Authors from pioneering groups report in their chapters on the tissue homeostatic, tissue regenerating and regulatory properties of NAbs and NAbs in pooled human IgG. Scientists interested in the regulation and modulation of components of the immune system found a whole variety of NAbs to cytokines with regulatory and protective functions and NAbs that modulate, e.g., dendritic cells, regulatory T cells, B cells and granulocytes. Considering the large plasma pools and initial difficulties in preparing IVIG that does not induce adverse effects upon infusion into recipients, this volume ends with a historical chapter on how pooled human plasma was fractionated and the IgG component pretreated for a safe intravenous application.

Neonatal Hematology

Author: Pedro A. de Alarcón

Publisher: Cambridge University Press

Published: 2021-02-18

Total Pages: 501

ISBN-13: 1108488986

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An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.

Trace Elements and Minerals in Health and Longevity

Author: Marco Malavolta

Publisher: Springer

Published: 2018-11-13

Total Pages: 328

ISBN-13: 3030037428

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This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.