Regulation of Body Weight

Regulation of Body Weight PDF

Author: Claude Bouchard

Publisher:

Published: 1996-06-19

Total Pages: 352

ISBN-13:

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The fact that about 30-40% of the adults in the Western world are overweight or obese testifies to the frequency of the disturbances in body weight regulation. Scientists have established that caloric intake, macronutrient composition of the diet, basal and resting metabolic rate, thermic response to food, energy expenditure associated with movement and physical activity, and preferential storage of the surplus of calories as fat or lean tissues are critical determinants of energy balance and body weight. While much has been learned, the field is poised for major advances with the advent of a variety of imaging techniques, progress in quantitative and molecular genetics, use of transgenic rodent models and of breeding experiments with informative inbred strains, availability of stable isotopes for metabolic and behavioral studies, and a growing number of useful experimental animal and human models. This volume takes an integrative approach to obesity. It is structured around four major topics: (1) the animal and human models currently available for the study of body weight regulation with their strengths and limitations, (2) the molecular and genetic basis of the regulation of body weight, (3) the metabolic and physiological mechanisms involved, and (4) the behavioral and social determinants. The 13 background papers provide a critical overview of the present knowledge base while the group reports summarize the extensive deliberations of 38 international experts. Particular emphasis has been given to promising research areas and on the advances needed to ensure a better understanding of the biological and behavioral mechanisms of the regulation of body weight, with a particular emphasis on overweight and obesity.

Weight Management

Weight Management PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2003-12-01

Total Pages: 277

ISBN-13: 0309089964

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The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

Clinical Neuroendocrinology

Clinical Neuroendocrinology PDF

Author: Michael Wilkinson

Publisher: Cambridge University Press

Published: 2019-01-03

Total Pages: 207

ISBN-13: 1316645193

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A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Brain Somatic Cross-Talk and the Central Control of Metabolism

Brain Somatic Cross-Talk and the Central Control of Metabolism PDF

Author: Claude Kordon

Publisher: Springer Science & Business Media

Published: 2003-02-12

Total Pages: 224

ISBN-13: 9783540000907

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The present book summarizes presentations to an IPSEN Foundation Conference on Brain Somatic Cross Talk and the Central Control of Metabolism, organised in 2002. It proposes a state-of-the-art outline of the multifaceted neuronal networks which serve the highly selective purpose of adapting growth, metabolism, reproduction, and more generally energy consumption to the availability of food resources. The physiology of over twenty neurotransmitters and peptides underlying these functions is presented, together with their neuronal targets, their mechanism of action and their current or anticipated relevance for pathology. Functions covered are as diverse as regulation of food intake and sleep, adaptation to emergency situations, and finally mental disorders - as well as early, irreversible imprinting of epigenetic influences on physiological and behavioural patterns, which in some cases can even be transmitted from generation to generation. Book jacket.

Appetite and Body Weight

Appetite and Body Weight PDF

Author: Tim Kirkham

Publisher: Elsevier

Published: 2011-04-28

Total Pages: 384

ISBN-13: 9780080466460

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There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication. Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.) Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds

Weighing the Options

Weighing the Options PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1995-03-01

Total Pages: 296

ISBN-13: 0309132576

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Nearly one out of every three adults in America is obese and tens of millions of people in the United States are dieting at any one time. This has resulted in a weight-loss industry worth billions of dollars a year and growing. What are the long-term results of weight-loss programs? How can people sort through the many programs available and select one that is right for them? Weighing the Options strives to answer these questions. Despite widespread public concern about weight, few studies have examined the long-term results of weight-loss programs. One reason that evaluating obesity management is difficult is that no other treatment depends so much on an individual's own initiative and state of mind. Now, a distinguished group of experts assembled by the Institute of Medicine addresses this compelling issue. Weighing the Options presents criteria for evaluating treatment programs for obesity and explores what these criteria meanâ€"to health care providers, program designers, researchers, and even overweight people seeking help. In presenting its criteria the authors offer a wealth of information about weight loss: how obesity is on the rise, what types of weight-loss programs are available, how to define obesity, how well we maintain weight loss, and what approaches and practices appear to be most successful. Information about weight-loss programsâ€"their clients, staff qualifications, services, and success ratesâ€"necessary to make wise program choices is discussed in detail. The book examines how client demographics and characteristicsâ€"including health status, knowledge of weight-loss issues, and attitude toward weight and body imageâ€"affect which programs clients choose, how successful they are likely to be with their choices, and what this means for outcome measurement. Short- and long-term safety consequences of weight loss are discussed as well as clinical assessment of individual patients. The authors document the health risks of being overweight, summarizing data indicating that even a small weight loss reduces the risk of disease and depression and increases self-esteem. At the same time, weight loss has been associated with some poor outcomes, and the book discusses the implications for program evaluation. Prevention can be even more important than treatment. In Weighing the Options, programs for population groups, efforts targeted to specific groups at high risk for obesity, and prevention of further weight gain in obese individuals get special attention. This book provides detailed guidance on how the weight-loss industry can improve its programs to help people be more successful at long-term weight loss. And it provides consumers with tips on selecting a program that will improve their chances of permanently losing excess weight.

Body Weight Regulation: Essential Knowledge to Lose Weight and Keep It Off

Body Weight Regulation: Essential Knowledge to Lose Weight and Keep It Off PDF

Author: Joseph Proietto

Publisher: Xlibris Corporation

Published: 2016-08-12

Total Pages: 106

ISBN-13: 1514497034

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The main purpose of Body Weight Regulation is to educate the reader on the best strategy for losing weight and keeping it off long term. But after many years of managing obesity, the author has found that to achieve the best results, it is essential to understand the true nature of obesity. Thus this book first discusses the way the brain regulates body weight and how obesity cannot be caused only by poor lifestyle choices. It reviews the overwhelming evidence that obesity has a strong genetic or epigenetic basis and gives an evidence-based, detailed strategy on how to lose weight and keep it off . Body Weight Regulation discusses practical advice on how to structure meals that can be used during the weight-loss and weight-maintenance phases.

Metabolic Regulation

Metabolic Regulation PDF

Author: Keith N. Frayn

Publisher: John Wiley & Sons

Published: 2013-03-18

Total Pages: 385

ISBN-13: 1118685334

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The important Third Edition of this successful book conveys a modern and integrated picture of metabolism and metabolic regulation. Explaining difficult concepts with unequalled clarity, author Keith Frayn provides the reader with an essential guide to the subject. Covering topics such as energy balance, body weight regulation and how the body copes with extreme situations, this book illustrates how metabolic regulation allows the human body to adapt to many different conditions. Changes throughout the new edition include: Extensive chapter updates Clear and accessible 2-color diagrams Q&A sections online at www.wiley.com/go/fraynto facilitate learning Frayn has written a book which will continue to be an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing.

Body Composition and Physical Performance

Body Composition and Physical Performance PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1992-02-01

Total Pages: 371

ISBN-13: 030904586X

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This book surveys the entire field of body composition as it relates to performance. It includes a clear definition of terminology and a discussion of the various methods for measuring body composition. The authored papers represent a state-of-the-art review of this controversial field and address questions such as: What is a better measure of body compositionâ€"body fat or lean body mass? Does being overweight for one's height really affect performance? The book also addresses the issue of physical appearance as it relates to body fatness and performance. It includes an in-depth discussion of many of the topics of interest to those involved in sports medicine and exercise physiology.