Regression Methods in Biostatistics

Regression Methods in Biostatistics PDF

Author: Eric Vittinghoff

Publisher: Springer Science & Business Media

Published: 2012-03-06

Total Pages: 526

ISBN-13: 1461413532

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This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes. Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way. The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided.

Bayesian and Frequentist Regression Methods

Bayesian and Frequentist Regression Methods PDF

Author: Jon Wakefield

Publisher: Springer Science & Business Media

Published: 2013-01-04

Total Pages: 700

ISBN-13: 1441909257

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Bayesian and Frequentist Regression Methods provides a modern account of both Bayesian and frequentist methods of regression analysis. Many texts cover one or the other of the approaches, but this is the most comprehensive combination of Bayesian and frequentist methods that exists in one place. The two philosophical approaches to regression methodology are featured here as complementary techniques, with theory and data analysis providing supplementary components of the discussion. In particular, methods are illustrated using a variety of data sets. The majority of the data sets are drawn from biostatistics but the techniques are generalizable to a wide range of other disciplines.

Regression

Regression PDF

Author: N. H. Bingham

Publisher: Springer Science & Business Media

Published: 2010-09-17

Total Pages: 293

ISBN-13: 1848829698

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Regression is the branch of Statistics in which a dependent variable of interest is modelled as a linear combination of one or more predictor variables, together with a random error. The subject is inherently two- or higher- dimensional, thus an understanding of Statistics in one dimension is essential. Regression: Linear Models in Statistics fills the gap between introductory statistical theory and more specialist sources of information. In doing so, it provides the reader with a number of worked examples, and exercises with full solutions. The book begins with simple linear regression (one predictor variable), and analysis of variance (ANOVA), and then further explores the area through inclusion of topics such as multiple linear regression (several predictor variables) and analysis of covariance (ANCOVA). The book concludes with special topics such as non-parametric regression and mixed models, time series, spatial processes and design of experiments. Aimed at 2nd and 3rd year undergraduates studying Statistics, Regression: Linear Models in Statistics requires a basic knowledge of (one-dimensional) Statistics, as well as Probability and standard Linear Algebra. Possible companions include John Haigh’s Probability Models, and T. S. Blyth & E.F. Robertsons’ Basic Linear Algebra and Further Linear Algebra.

Handbook of Regression and Modeling

Handbook of Regression and Modeling PDF

Author: Daryl S. Paulson

Publisher: CRC Press

Published: 2006-12-19

Total Pages: 522

ISBN-13: 1420017381

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Carefully designed for use by clinical and pharmaceutical researchers and scientists, Handbook of Regression Analysis and Modeling explores statistical methods that have been adapted into biological applications for the quickly evolving field of biostatistics. The author clearly delineates a six-step method for hypothesis testing using data that mi

Robust Methods in Biostatistics

Robust Methods in Biostatistics PDF

Author: Stephane Heritier

Publisher: John Wiley & Sons

Published: 2009-05-11

Total Pages: 292

ISBN-13: 9780470740545

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Robust statistics is an extension of classical statistics that specifically takes into account the concept that the underlying models used to describe data are only approximate. Its basic philosophy is to produce statistical procedures which are stable when the data do not exactly match the postulated models as it is the case for example with outliers. Robust Methods in Biostatistics proposes robust alternatives to common methods used in statistics in general and in biostatistics in particular and illustrates their use on many biomedical datasets. The methods introduced include robust estimation, testing, model selection, model check and diagnostics. They are developed for the following general classes of models: Linear regression Generalized linear models Linear mixed models Marginal longitudinal data models Cox survival analysis model The methods are introduced both at a theoretical and applied level within the framework of each general class of models, with a particular emphasis put on practical data analysis. This book is of particular use for research students,applied statisticians and practitioners in the health field interested in more stable statistical techniques. An accompanying website provides R code for computing all of the methods described, as well as for analyzing all the datasets used in the book.

Regression Modeling Strategies

Regression Modeling Strategies PDF

Author: Frank E. Harrell

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 583

ISBN-13: 147573462X

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Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".

Applications of Regression Models in Epidemiology

Applications of Regression Models in Epidemiology PDF

Author: Erick Suárez

Publisher: John Wiley & Sons

Published: 2017-02-28

Total Pages: 276

ISBN-13: 1119212480

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A one-stop guide for public health students and practitioners learning the applications of classical regression models in epidemiology This book is written for public health professionals and students interested in applying regression models in the field of epidemiology. The academic material is usually covered in public health courses including (i) Applied Regression Analysis, (ii) Advanced Epidemiology, and (iii) Statistical Computing. The book is composed of 13 chapters, including an introduction chapter that covers basic concepts of statistics and probability. Among the topics covered are linear regression model, polynomial regression model, weighted least squares, methods for selecting the best regression equation, and generalized linear models and their applications to different epidemiological study designs. An example is provided in each chapter that applies the theoretical aspects presented in that chapter. In addition, exercises are included and the final chapter is devoted to the solutions of these academic exercises with answers in all of the major statistical software packages, including STATA, SAS, SPSS, and R. It is assumed that readers of this book have a basic course in biostatistics, epidemiology, and introductory calculus. The book will be of interest to anyone looking to understand the statistical fundamentals to support quantitative research in public health. In addition, this book: • Is based on the authors’ course notes from 20 years teaching regression modeling in public health courses • Provides exercises at the end of each chapter • Contains a solutions chapter with answers in STATA, SAS, SPSS, and R • Provides real-world public health applications of the theoretical aspects contained in the chapters Applications of Regression Models in Epidemiology is a reference for graduate students in public health and public health practitioners. ERICK SUÁREZ is a Professor of the Department of Biostatistics and Epidemiology at the University of Puerto Rico School of Public Health. He received a Ph.D. degree in Medical Statistics from the London School of Hygiene and Tropical Medicine. He has 29 years of experience teaching biostatistics. CYNTHIA M. PÉREZ is a Professor of the Department of Biostatistics and Epidemiology at the University of Puerto Rico School of Public Health. She received an M.S. degree in Statistics and a Ph.D. degree in Epidemiology from Purdue University. She has 22 years of experience teaching epidemiology and biostatistics. ROBERTO RIVERA is an Associate Professor at the College of Business at the University of Puerto Rico at Mayaguez. He received a Ph.D. degree in Statistics from the University of California in Santa Barbara. He has more than five years of experience teaching statistics courses at the undergraduate and graduate levels. MELISSA N. MARTÍNEZ is an Account Supervisor at Havas Media International. She holds an MPH in Biostatistics from the University of Puerto Rico and an MSBA from the National University in San Diego, California. For the past seven years, she has been performing analyses for the biomedical research and media advertising fields.

Dynamic Regression Models for Survival Data

Dynamic Regression Models for Survival Data PDF

Author: Torben Martinussen

Publisher: Springer Science & Business Media

Published: 2007-11-24

Total Pages: 470

ISBN-13: 0387339604

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This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the aim of describing time-varying effects of explanatory variables. Use of the suggested models and methods is illustrated on real data examples, using the R-package timereg developed by the authors, which is applied throughout the book with worked examples for the data sets.