Radioisotopic Methods for Biological and Medical Research

Radioisotopic Methods for Biological and Medical Research PDF

Author: Herman W. Knoche

Publisher: Oxford University Press on Demand

Published: 1991

Total Pages: 432

ISBN-13: 9780195058062

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This book is an up-to-date textbook for biologists and biomedical scientists covering the basics of radioisotope methodology and safety. Radioisotopes are widely used in biological and medical research, particularly in biochemistry. Graduate students and technicians usually learn how to use radioisotopes through short training courses or as part of laboratory courses in biology and biochemistry. This text was written for use in courses on the theoretical aspects of radioisotopic methods or for self-study and reference; it assumes little knowledge of radioactive materials and develops mathematical discussions slowly and clearly. The focus of the book is on the topics listed on the U.S. Nuclear Regulatory Commission's license application: principles and practices of radiation protection; radioactivity measurement, standardization and monitoring techniques and instruments; mathematics and calculations basic to the use and measurement of radioactivity; and biological effects of radiation.

Radioisotopes in Biology

Radioisotopes in Biology PDF

Author: Robert J. Slater

Publisher: Practical Approach Series

Published: 2002

Total Pages: 332

ISBN-13: 9780199638260

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Provides an introduction to the use of radioactivity in the bioscience laboratory. The text covers general aspects of radioactivity, methods for the detection of radioactivity, radioisotope protocols used to study key cellular processes, and a summary of legislative requirements in the US and European Union. Guidance on safe handling and detailed recipes are provided.

Radioactive Isotopes in Biological Research

Radioactive Isotopes in Biological Research PDF

Author: William R. Hendee

Publisher: John Wiley & Sons

Published: 1973

Total Pages: 392

ISBN-13:

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Structure of the atom. Radioactive decay. Interaction of particulate radiation. Interactions of X radiation and y radiation. Production of radioactive nuclides. Synthesis of labeled compounds. Radioactive pharmaceuticals. Gas-filled detectors. External scintillation detectors. Semiconductor radiation detectors. Nuclear counting systems. Scientillation spectrometry. Sample preparations for external counting. Sample preparation for liquid scintilation counting. Liquid scintillation counting. autoradiography and radiochromatography. Activation analysis. Statistics of radioactivity measurements. Quantitative measurement of radioactivity. Dynamic function studies. Scanning and whote-body counting. Radiation exposure and dose. Internal absorbed dose. Guidelines for radiation protection. Radiation safety.

Isotopes for Medicine and the Life Sciences

Isotopes for Medicine and the Life Sciences PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1995-01-27

Total Pages: 144

ISBN-13: 0309176697

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Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.

Life Atomic

Life Atomic PDF

Author: Angela N. H. Creager

Publisher: University of Chicago Press

Published: 2013-10-02

Total Pages: 506

ISBN-13: 022601794X

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After World War II, the US Atomic Energy Commission (AEC) began mass-producing radioisotopes, sending out nearly 64,000 shipments of radioactive materials to scientists and physicians by 1955. Even as the atomic bomb became the focus of Cold War anxiety, radioisotopes represented the government’s efforts to harness the power of the atom for peace—advancing medicine, domestic energy, and foreign relations. In Life Atomic, Angela N. H. Creager tells the story of how these radioisotopes, which were simultaneously scientific tools and political icons, transformed biomedicine and ecology. Government-produced radioisotopes provided physicians with new tools for diagnosis and therapy, specifically cancer therapy, and enabled biologists to trace molecular transformations. Yet the government’s attempt to present radioisotopes as marvelous dividends of the atomic age was undercut in the 1950s by the fallout debates, as scientists and citizens recognized the hazards of low-level radiation. Creager reveals that growing consciousness of the danger of radioactivity did not reduce the demand for radioisotopes at hospitals and laboratories, but it did change their popular representation from a therapeutic agent to an environmental poison. She then demonstrates how, by the late twentieth century, public fear of radioactivity overshadowed any appreciation of the positive consequences of the AEC’s provision of radioisotopes for research and medicine.

Principles of Radioisotope Methodology

Principles of Radioisotope Methodology PDF

Author: Grafton D Chase

Publisher: Hassell Street Press

Published: 2021-09-09

Total Pages: 398

ISBN-13: 9781013671906

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This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Radioactive Tracers in Biology

Radioactive Tracers in Biology PDF

Author: Martin D. Kamen

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 444

ISBN-13: 1483274470

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Radioactive Tracers in Biology: An Introduction to Trace Methodology, Second Edition focuses on the biochemical and physiological aspects of tracer research, including medical applications of tracer techniques, radioactivity, radiation hazards, and radioactive isotopes. The book first offers information on atomic nuclei, radioactivity, and the production of radioactive isotopes and radiation characteristics of tracer atoms. Discussions focus on nuclear reactions, neutron-induced and deuteron-induced transmutations, properties of atomic nuclei, and target techniques and radiochemistry. The manuscript also ponders on the procedures for radioactive assay and radiation hazards. The text examines the biochemical, medical, and physiological applications of tracer methodology. The manuscript also takes a look at radioactive hydrogen, short-lived and long-lived radioactive carbon, radioactive phosphorus and sulfur, and alkali metal and alkaline earth tracers. Topics include synthesis of organic intermediates for tracer carbon studies; biosynthesis of labeled carbon compounds; and general survey of alkali metal tracers. The publication is a dependable reference for readers interested in radioactive tracers.

Advancing Nuclear Medicine Through Innovation

Advancing Nuclear Medicine Through Innovation PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2007-09-11

Total Pages: 173

ISBN-13: 0309134153

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Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

The Supply of Medical Isotopes

The Supply of Medical Isotopes PDF

Author:

Publisher:

Published: 2019

Total Pages: 122

ISBN-13: 9789264625099

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This report explores the main reasons behind the unreliable supply of Technetium-99m (Tc-99m) in health-care systems and policy options to address the issue. Tc-99m is used in 85% of nuclear medicine diagnostic scans performed worldwide – around 30 million patient examinations every year. These scans allow diagnoses of diseases in many parts of the human body, including the skeleton, heart and circulatory system, and the brain. Medical isotopes are subject to radioactive decay and have to be delivered just-in-time through a complex supply chain. However, ageing production facilities and a lack of investment have made the supply of Tc-99m unreliable. This report analyses the use and substitutability of Tc-99m in health care, health-care provider payment mechanisms for scans, and the structure of the supply chain. It concludes that the main reasons for unreliable supply are that production is not economically viable and that the structure of the supply chain prevents producers from charging prices that reflect the full costs of production and supply.