Platelets, Haemostasis and Inflammation

Platelets, Haemostasis and Inflammation PDF

Author: Andreas Zirlik

Publisher: Springer

Published: 2017-12-21

Total Pages: 295

ISBN-13: 3319662244

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The book depicts the various roles of platelets in a variety of cardio-metabolic diseases. Traditional and non-traditional platelet functions are described in detail in atherosclerosis, metabolic syndrome, diabetes, myocardial infarction, and other vascular pathologies. Particular focus is put on platelets as a link between haemostasis and inflammation contributing to both. Last but not least the books links the most recent advances in basic sciences with promising novel therapeutic applications and first results of clinical trials. The book is written for biomedical scientists in the sub disciplines vascular biology, biochemistry and immunology; and it as well will be of interest and value for academic physicians like cardiologists, hematologists, general internists and vascular surgeons.

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease PDF

Author: Robert Fitridge

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 589

ISBN-13: 1922064009

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Platelets in Thrombotic and Non-Thrombotic Disorders

Platelets in Thrombotic and Non-Thrombotic Disorders PDF

Author: Paolo Gresele

Publisher: Springer

Published: 2017-03-08

Total Pages: 1402

ISBN-13: 3319474626

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This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis

Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis PDF

Author: Rolando E. Rumbaut

Publisher: Biota Publishing

Published: 2010-02-01

Total Pages: 77

ISBN-13: 1615040404

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Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.

The Non-Thrombotic Role of Platelets in Health and Disease

The Non-Thrombotic Role of Platelets in Health and Disease PDF

Author: Steve W. Kerrigan

Publisher: BoD – Books on Demand

Published: 2015-11-18

Total Pages: 250

ISBN-13: 9535122088

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Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Inflammation, Hemostasis, and Blood Conservation Strategies

Inflammation, Hemostasis, and Blood Conservation Strategies PDF

Author: Jerrold H. Levy

Publisher: W B Saunders Company

Published: 2007

Total Pages: 206

ISBN-13: 9781416043225

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This issue reviews inflammation, hemostasis, and blood conservation strategies in patients following surgery, trauma, or complex injuries, and focuses on coagulopathies due to multiple factors including hemorrhage, surgical injuries, or drugs that affect the hemostatic system. Hemostasis and therapeutic approaches for bleeding and medical patients are discussed, including important aspects of thrombin signaling, protease activated receptor involvement, platelet dysfunction, and clot stabilization.The increasing problem of heparin-induced thrombocytopenia as a prothrombotic disease is discussed. Different approaches to reduce bleeding and transfusion requirements in critically ill patients are included based on either preventing or reversing the defects associated with coagulopathies. Blood conservation and the risks of transfusions are reviewed, including an update on transfusion-related acute lung injury. Pharmacologic approaches, an important aspect of blood conservation and are reviewed, including the recent New England Journal of Medicine controversy about aprotinin. Strategies involved in blood conservation in critically ill patients is included with focus on pharmacologic blood-sparing studies. Multiple pharmacologic approaches to reducing and treating bleeding are reviewed. Current and future pharmacologic approaches to attenuating hemostatic system activation, inflammation, and bleeding, and the potential need for allogeneic blood administration are important focuses of this issue.

Platelets in Cardiovascular Disease

Platelets in Cardiovascular Disease PDF

Author: Deepak L. Bhatt

Publisher: Imperial College Press

Published: 2008

Total Pages: 235

ISBN-13: 1860948529

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Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives.

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