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Pharmacology of Cytokines

Author: Alberto Mantovani

Publisher: Oxford University Press, USA

Published: 2000

Total Pages: 354

ISBN-13:

Cytokines are the "words" of immunity, serving as mediators within and outside the immune system. There is tremendous interest in their expliotation as therapeutic tools in diverse human diseases and considerable effort has been made to understand and utilize their pharmacology. This book examines this pharmacology, from developments and characterization of simple chemicals and their mechanism of action to the use of biotechnology-based approaches. The book puts cytokines and their pharmacology in context and examines their involvement in individual organ-disease systems.

Immunopharmacology

Author: Manzoor M. Khan

Publisher: Springer Science & Business Media

Published: 2008-12-19

Total Pages: 275

ISBN-13: 0387779760

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During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

New Cytokines as Potential Drugs

Author: Satwant K. Narula

Publisher: Springer

Published: 2012-11-19

Total Pages: 166

ISBN-13: 3034884567

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Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...

Cytokines

Author: Anthony R. Mire-Sluis

Publisher: Academic Press

Published: 1998-04-15

Total Pages: 609

ISBN-13: 0080530214

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This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book. Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information. Genetic information and sequences Protein structure Cell sources and production Biological activity Cytokine receptor structure and signal transduction Discussion of the role of cytokines in disease and the potential for therapy Summary table of essential facts Comprehensive bibliography

Therapeutic Modulation of Cytokines

Author: M. W. Bodmer

Publisher: CRC Press

Published: 1996-01-23

Total Pages: 362

ISBN-13: 9780849383816

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Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.

Novel Cytokine Inhibitors

Author: Gerry A. Higgs

Publisher: Springer

Published: 2012-12-06

Total Pages: 284

ISBN-13: 3034884508

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Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.

Immunopharmacology and Inflammation

Author: Carlo Riccardi

Publisher: Springer

Published: 2018-06-09

Total Pages: 331

ISBN-13: 3319776584

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A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Cytokines and Mental Health

Author: Ziad Kronfol

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 436

ISBN-13: 146150323X

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Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role of cytokines in neuropsychiatric disorders such as major depression, schizophrenia and Alzheimer's disease. The book offers different things to different people. It should be of great interest to neuroscientists and immunologists working in the field of psychoneuroimmunology. It would also greatly benefit mental health professionals including psychiatrists, psychologists and clinicians of diverse background who are interested in mind-body medicine.

Cytokines in Human Health

Author: Robert V. House

Publisher: Humana

Published: 2010-12-01

Total Pages: 0

ISBN-13: 9781617375866

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This comprehensive book explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. It includes a basic study of cytokines and details the effects of cytokines on the immune system and in treating cancer. The book serves as both a primer and a starting point for a more detailed investigation of the role these biological regulators play.

New Cytokines as Potential Drugs

Author: Satwant K. Narula

Publisher:

Published: 2000-01

Total Pages: 141

ISBN-13: 9780817658830

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