Peptide, Protein and Enzyme Design

Peptide, Protein and Enzyme Design PDF

Author:

Publisher: Academic Press

Published: 2016-08-27

Total Pages: 684

ISBN-13: 0128054344

DOWNLOAD EBOOK →

De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism

Molecular Design and Modeling

Molecular Design and Modeling PDF

Author: John Joseph Langone

Publisher: Gulf Professional Publishing

Published: 1991

Total Pages: 864

ISBN-13: 9780121821036

DOWNLOAD EBOOK →

Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.

Protein Engineering and Design

Protein Engineering and Design PDF

Author: Paul R. Carey

Publisher: Elsevier

Published: 1996-06-21

Total Pages: 379

ISBN-13: 0080539971

DOWNLOAD EBOOK →

The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides

Proteins

Proteins PDF

Author: Ruth Hogue Angeletti

Publisher: Elsevier

Published: 1998-09-14

Total Pages: 378

ISBN-13: 0080539998

DOWNLOAD EBOOK →

Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function. Provides problems and technical solutions Includes posttranslational modifications Uses synthetic peptides as biological models Details mutagenesis and protein engineering Covers design of protein structure and function

Methods in Protein Design

Methods in Protein Design PDF

Author:

Publisher: Academic Press

Published: 2013-02-14

Total Pages: 539

ISBN-13: 0123946298

DOWNLOAD EBOOK →

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins

Protein Engineering Protocols

Protein Engineering Protocols PDF

Author: Kristian Müller

Publisher: Springer Science & Business Media

Published: 2007-10-26

Total Pages: 318

ISBN-13: 1597451878

DOWNLOAD EBOOK →

Protein engineering is a fascinating mixture of molecular biology, protein structure analysis, computation, and biochemistry, with the goal of developing useful or valuable proteins. Protein Engineering Protocols will consider the two general, but not mutually exclusive, strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The s- ond strategy is known as directed evolution. In this case, random mutagenesis is applied to a protein, and selection or screening is used to pick out variants that have the desired qualities. By several rounds of mutation and selection, this method mimics natural evolution. An additional technique known as DNA shuffling mixes and matches pieces of successful variants to produce better results. This process mimics recombination that occurs naturally during sexual reproduction. The first section of Protein Engineering Protocols describes rational p- tein design strategies, including computational methods, the use of non-natural amino acids to expand the biological alphabet, as well as impressive examples for the generation of proteins with novel characteristics. Although procedures for the introduction of mutations have become routine, predicting and und- standing the effects of these mutations can be very challenging and requires profound knowledge of the system as well as protein structures in general.

Protein Design

Protein Design PDF

Author: Raphael Guerois

Publisher: Springer Science & Business Media

Published: 2008-02-04

Total Pages: 303

ISBN-13: 1597451169

DOWNLOAD EBOOK →

Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.

Amino Acids and Peptides

Amino Acids and Peptides PDF

Author: G. C. Barrett

Publisher: Cambridge University Press

Published: 1998-10-29

Total Pages: 246

ISBN-13: 9780521468275

DOWNLOAD EBOOK →

This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

Lanterna Rally - Theme by Grace Themes