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Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes

Author: Yechiel Becker

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 391

ISBN-13: 3642850049

Six members of the Herpesviridae family are human pathogens, including herpes and 2 (HSV-I and 2), Epstein-Barr virus (EBV), varicella zoster simplex virus I virus (VZV), human cytomegalovirus (HCMV), and human herpesvirus 6 (HHV 6). Each of these viruses is capable of causing distinct diseases of varying severity in children, young adults, and the aged. The diseases range from infection of epithelial tissue to the infection of internal organs and white blood cells. A common feature of the six pathogenic human herpesviruses is their ability to latently infect different cell types in which the viral DNA is not integrated and is unable to express its pathogenicity. Reactivation of the herpesviruses is a result of cellular processes which reactivate viral genes, leading to virus progeny and to signs of infection. Due to their ability to become latent after initial infection, once the pathogenic herpesviruses infect children they are maintained throughout life, having the potential of cause various diseases upon reactivation.

Pathogenicity of Human Herpesviruses Due to Specific Pathogenicity Genes

Author: Yechiel Becker

Publisher: Springer

Published: 1994-01-01

Total Pages: 387

ISBN-13: 9783540571278

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The questions of how the pathogenic human herpesviruses cause diseases, and what should be done to prevent infection and disease have prompted scientific interest in the molecular basis of the functions of all human herpesvirus genes in various tissues and organs of the infected host. This volume compiles the knowledge on the pathogenicity genes of herpes simplex virus types 1 and 2, the ones which have been most actively investigated at the molecular level. It adds to the understanding of herpesvirus gene involvement in diseases and shows the potential of this knowledge for planning new strategies for the development of vaccines in the future. The book will be of great help to physicians and to scientists concerned with the involvement of herpesviruses in aggravating patients' conditions, leading to a life threatening infection.

Progress in Nucleic Acid Research and Molecular Biology

Author:

Publisher: Academic Press

Published: 1995-08-31

Total Pages: 369

ISBN-13: 9780080863399

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From the Reviews of Previous Volumes "In perusing these chapters, I found much of interest. It is worth investigating." -P. BRICKNELL "Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are ocncerned with the living cell." BRITISH MEDICAL JOURNAL Key Features * Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology * Contributions from leaders in their fields * Abundant references

Viral Pathogenesis

Author: Michael G. Katze

Publisher: Academic Press

Published: 2015-12-30

Total Pages: 366

ISBN-13: 0128011742

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Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Human Herpesvirus Infection

Author: Ronaldo Luis Thomasini

Publisher: BoD – Books on Demand

Published: 2020-04-01

Total Pages: 130

ISBN-13: 1838811583

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The relationship between herpesviruses and humans probably dates from thousands of years ago. In the last few decades, many aspects of herpesvirus infections have been understood, such as infections with a range of manifestations (severe, mild, or subclinical). Herpesvirus can remain latent during a lifetime and sometimes their reactivation can cause different clinical features in the patient. Several conditions have been related to herpesvirus reactivation such as complications in transplant organ recipients and immune regulatory modification in the elderly. Aspects of human herpesvirus simples, varicella-zoster virus, and cytomegalovirus are presented and discussed in this book.

Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Molecular Virology of Human Pathogenic Viruses

Author: Wang-Shick Ryu

Publisher: Academic Press

Published: 2016-03-30

Total Pages: 440

ISBN-13: 0128009993

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Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Advances in Virus Research

Author:

Publisher: Academic Press

Published: 1998-11-03

Total Pages: 371

ISBN-13: 0080583415

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Advances in Virus Research

Fenner and White's Medical Virology

Author: Christopher J. Burrell

Publisher: Academic Press

Published: 2016-11-09

Total Pages: 604

ISBN-13: 0123751578

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Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Herpes Simplex Virus

Author: Barry T. Rouse

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 188

ISBN-13: 3642772471

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Although upstaged by the tragic appearance of the human immunodeficiency virus, herpes simplex viruses (HSV) types 1 and 2 continue to be major human pathogens against which we lack acceptable vaccines or other means of immunological control. The virus is large and complex, coding for 70 or more proteins. Although many mysteries remain to be unraveled, our knowledge base regarding genomic organization, gene expression and regulation, pathogenesis, and immune recog nition of component parts is quite considerable. Indeed, meet ings devoted entirely to herpesviruses are conspicuous by their frequency and excellent, yet sometimes exclusive, attendance. The purpose of this volume is to compile in a single book a series of reviews by leading investigators that deal with various aspects of virus-host interactions and which hopefully will pro vide clues as to how to best manage HSV from an immunobio logical perspective. Ultimately, one anticipates that a full under standing of virus-host interaction will lead to strategies useful for the prevention and control of HSV. The state of current progress with conventional vaccines is presented, as is a chapter on intracellular immunization. This latter novel approach to virus infections comes at approximately the bicentenary of Jenner's introduction of a successful conventional immunization strategy.