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Pathogenesis of Wound and Biomaterial-Associated Infections

Author: Torkel Wadström

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 537

ISBN-13: 1447134540

Despite the recent advances in medical treatment, patients suffering from wounds such as burns or receiving surgical implants are still in great danger of infection. This has called attention to the need for better understanding of infections at the molecular level. Scientists from various disciplines summarize our knowledge today and investigate how methods to avoid wound and biomaterial-associated infections can be developed. These methods include new antibiotics, surgical strategies to prevent infection, and ways to stimulate the immune system and the tissue healing process. Specific topics include: the definition of microbial cell surface determinants important for adhesion to graft; the definition of extracellular bacterial enzymes and toxins involved in tissue breakdown and the local spread of infection; the prevention of the systemic spreading of infection with immunoglobulins and antibiotics; and the problem of multiple antibiotic resistance in most versatile pathogens.

Racing for the Surface

Author: Bingyun Li

Publisher: Springer Nature

Published: 2020-03-02

Total Pages: 648

ISBN-13: 3030344754

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This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.

Biofilm Infections

Author: Thomas Bjarnsholt

Publisher: Springer

Published: 2014-10-11

Total Pages: 0

ISBN-13: 9781489982285

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This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

Coagulase-negative Staphylococci

Author: Per-Anders Mårdh

Publisher: Coronet Books

Published: 1986

Total Pages: 232

ISBN-13:

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Wound Healing and Skin Physiology

Author: Peter Altmeyer

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 701

ISBN-13: 3642778828

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On the occasion of the European Congress on Wound Healing and Skin Physiology (Bochum, Germany, November 1992), an international team of scientists and clinicians discussed the core topics in this important field of dermatological and surgical research. Themes include morphology and physiology, microcirculation and angiogenesis, biochemistry and immunology, microbiology and wound infection, non-invasive measurement techniques, wound repair, surgical treatment, dressings, and agents that promote wound healing.

Therapeutic Dressings and Wound Healing Applications

Author: Joshua Boateng

Publisher: John Wiley & Sons

Published: 2020-03-09

Total Pages: 444

ISBN-13: 1119433266

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The latest research on techniques for effective healing of chronic and difficult to heal wounds The healing of chronic wounds is a global medical concern, specifically for patients suffering from obesity and type II diabetes. Therapeutic Dressing and Wound Healing Applications is an essential text for research labs, industry professionals, and general clinical practitioners that want to make the shift towards advanced therapeutic dressing and groundbreaking wound application for better healing. This book takes a clinical and scientific approach to wound healing, and includes recent case studies to highlight key points and areas of improvement. It is divided into two key sections that include insight into the biochemical basis of wounds, as well as techniques and recent advancements. Chapters include information on: ● Debridement and disinfection properties of wound dressing ● Biofilms, silver nanoparticles, and honey dressings ● Clinical perspectives for treating diabetic wounds ● Treating mixed infections ● Wound healing and tissue regeneration treatments ● Gene based therapy, 3D bioprinting and freeze-dried wafers Anyone looking to update and improve the treatment of chronic wounds for patients will find the latest pertinent information in Therapeutic Dressing and Wound Healing Applications.

Pseudomonas aeruginosa as an Opportunistic Pathogen

Author: Mario Campa

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 429

ISBN-13: 1461530369

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Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Antibiofilm Agents

Author: Kendra P. Rumbaugh

Publisher: Springer Science & Business Media

Published: 2014-05-08

Total Pages: 495

ISBN-13: 3642538339

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This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Biomaterial-Related Infections

Author: Natália Martins

Publisher: MDPI

Published: 2020-12-23

Total Pages: 204

ISBN-13: 3039434381

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The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.

Biomaterials and Medical Device - Associated Infections

Author: L Barnes

Publisher: Elsevier

Published: 2014-11-21

Total Pages: 281

ISBN-13: 0857097229

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Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection. Provides analysis of biofilms and their relevance to implant associated infections. Assesses technologies for controlling biofilms. Considers advantages and disadvantages of in vivo infection studies.