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Author: Robert B. Darnell
Publisher: OUP USA
Published: 2011-08-22
Total Pages: 497
ISBN-13: 0199772738
DOWNLOAD EBOOK →This text provides a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book provides an overview, classifying the disorders, describes a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general, and much more.
Author: Lora H. Winter
Publisher: Nova Science Publishers
Published: 2014
Total Pages: 0
ISBN-13: 9781631178788
DOWNLOAD EBOOK →Paraneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumour metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body's homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumour antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumours. These syndromes can even occur before the primary tumour is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.
Author: Karen Helton Rhodes
Publisher: John Wiley & Sons
Published: 2018-02-05
Total Pages: 864
ISBN-13: 1119337224
DOWNLOAD EBOOK →Blackwell’s Five-Minute Veterinary Consult Clinical Companion: Small Animal Dermatology, Third Edition offers accessible, reliable information on canine and feline dermatology using the popular Blackwell's Five-Minute Veterinary Consult format—now with new topics, updated therapeutics, and improved images. Provides fast access to reliable information on treating dermatologic diseases and conditions in dogs and cats Uses the popular Blackwell's Five-Minute Veterinary Consult format and alphabetic arrangement for quick reference Offers thorough updates to this popular handbook, including a new “basics” section, new topics, and updated therapeutics, as well as new and improved images of dermatoses for easy comparison with clinical cases Puts the most commonly used dermatology information at the clinician's fingertips for rapid decision-making Includes access to a companion website with client education handouts to download and use in practice
Author: Julien Bogousslavsky
Publisher: Cambridge University Press
Published: 2001-05-24
Total Pages: 418
ISBN-13: 9780521771450
DOWNLOAD EBOOK →An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
Author:
Publisher: Elsevier
Published: 2016-03-11
Total Pages: 568
ISBN-13: 0444634460
DOWNLOAD EBOOK →Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Author: Sanjay Srivastava
Publisher: BoD – Books on Demand
Published: 2012-03-28
Total Pages: 328
ISBN-13: 9535103946
DOWNLOAD EBOOK →This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.
Author:
Publisher: Elsevier
Published: 2024-03-15
Total Pages: 498
ISBN-13: 0128242175
DOWNLOAD EBOOK →This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. Profiles paraneoplastic diseases by tumor type Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis Presents individual syndromes of the CNS, PNS, NMJ, and muscle Investigates the role of antibody markers Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS Reviews therapeutic strategies and clinical approach to PNS patients
Author: Fred F. Ferri
Publisher: Elsevier Health Sciences
Published: 2019-06-01
Total Pages: 2136
ISBN-13: 0323679773
DOWNLOAD EBOOK →Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today’s medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.
Author: Jonathan DeRight
Publisher: Springer Nature
Published: 2021-12-09
Total Pages: 335
ISBN-13: 3030853721
DOWNLOAD EBOOK →The goal of this book is to provide brief-but-comprehensive information that can aid in rapid differential diagnosis and allow for more thorough follow-up if needed. This guide is intended to fit easily into the pocket of a lab coat or on your desk, giving readers an efficient way to find information about a specific disease or disorder to prepare for an upcoming case. The book is divided into two parts: Part 1 involves general psychometric and reference information including score classifications, formulas for score conversion, likelihood chaining, and reliable change, psychometric data for stand-alone and embedded PVTs, and the effects of common medications on cognition. Part 2 of the book is organized alphabetically by disease or disorder to promote quick searching, and each chapter provides straightforward information including definitions, subtypes, etiology, epidemiology, course, diagnostic criteria, expectations for test results, and links to more comprehensive sources. Whenever possible, information is gathered through up-to-date literature and high quality pubilcations such as systematic reviews or meta-analyses. Helpful references are provided for more extensive follow-up or further reading.
Author: Ursula Rüther
Publisher: S. Karger AG (Switzerland)
Published: 1998
Total Pages: 280
ISBN-13:
DOWNLOAD EBOOK →Paraneoplastic syndromes comprise a variety of signs and symptoms that are not directly caused by the primary tumor or its metastases. They may be metabolic, dystrophic or degenerative disorders resulting from remote humoral or hormonal effects, and spontaneously disappear after successful tumor excision or chemo- or radiotherapy. A few years ago, paraneoplastic syndromes were still thought to be rare. Today, we know that a single tumor is capable of producing a variety of hormones and that paraneoplastic syndromes are caused by this ectopic formation of hormones, hormone-like polypeptides, and growth factors. Recent research has shown that viral metabolic intermediates, mutated oncogenes, and suppressor genes may also be involved. The early diagnosis of a paraneoplastic syndrome is crucial, for it may point to an undetected tumor or signal tumor relapse. This book covers endocrinal, neurologic, muscular, cutaneous, hematologic and organ-associated paraneoplastic syndromes and provides a detailed description of their clinical symptoms, diagnosis and therapy. Aiming to promote the understanding of paraneoplastic syndromes, this volume is an indispensable source for their diagnosis and treatment in clinical oncology.
