Oxygen/Nitrogen Radicals: Cell Injury and Disease

Oxygen/Nitrogen Radicals: Cell Injury and Disease PDF

Author: Val Vallyathan

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 393

ISBN-13: 1461510872

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A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.

Oxygen/Nitrogen Radicals and Cellular Injury

Oxygen/Nitrogen Radicals and Cellular Injury PDF

Author: Kenneth B. Adler

Publisher: DIANE Publishing

Published: 2000-03

Total Pages: 142

ISBN-13: 0788185381

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Papers: characterization of inducible nitric oxide synthase expression in human airway epithelium; nitric oxide and its congeners in mitochondria; role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock; nitric oxide and peroxynitrite production in ocular inflammation; 5 papers on pulmonary/pollutant effects; 6 papers on oxidants and signal transduction, including impact of oxidative stress on signal transduction control by phosphotyrosine phosphatases; the nature of antioxidant defense mechanisms; lipid peroxidation products and antioxidants in human disease; and lung injury and oxidoreductases.

Oxygen/Nitrogen Radicals

Oxygen/Nitrogen Radicals PDF

Author: Val Vallyathan

Publisher: CRC Press

Published: 2004-04-14

Total Pages: 550

ISBN-13: 9780824748746

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The first state-of-the-art book dealing specifically with lung injury induced by oxygen and nitrogen radicals, this detailed treatise discusses molecular, cellular, and mechanistic events leading to pathophysiological outcomes; the role of oxidant species in the induction of these events; and potential therapeutic avenues targeting such molecular pathways. Important issues regarding oxidative stress involvement in the initiation and progression of pulmonary diseases-including diseases caused by occupational and environmental inhalation of toxicants-are discussed in the context of amelioration by antioxidants.

Free Radical Mechanisms of Tissue Injury

Free Radical Mechanisms of Tissue Injury PDF

Author: Mary Treinen Moslen

Publisher: CRC Press

Published: 1992-02-21

Total Pages: 238

ISBN-13: 9780849351617

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This timely volume describes the contributions of free radicals and reactive oxygen species to disease processes in a variety of tissues. Topics include the roles of lipid peroxide-modified lipoproteins in atherosclerosis, peroxidation products in retinopathy, reactive oxygen species and neutrophils in mycardial ischemia-reflow injury, iron and reactive oxygen species in hemoglobin-mediated CNS damage and in asbestos-mediated lung injury. Critical reviews examine the evidence for radical species in ethanol-induced liver injury and in muscular dystrophy. The wealth of new information presented makes this book valuable for teaching and an important reference volume for researchers exploring problems in human disease.