Outsmarting the Host: How Bacterial Pathogens Modulate Immune Responses in The Lung
Author: Gee W. Lau
Publisher: Frontiers Media SA
Published: 2021-03-22
Total Pages: 244
ISBN-13: 2889666123
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Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens
Author: Sudhanshu Shekhar
Publisher: Frontiers Media SA
Published: 2020-01-14
Total Pages: 195
ISBN-13: 2889633365
DOWNLOAD EBOOK →Trillions of commensal microbes reside on and inside the human body, including the intestinal and respiratory tracts, which encompass various microbial taxa, such as bacteria, fungi, archea and viruses. The close proximity of microbes with the host provides an opportunity to continually interact with each other. Advances in research approaches, including high-throughput sequencing, have allowed us to study host and commensal microbes at the genetic and functional levels. Recent studies suggest that commensal microbes play a crucial role in the development of the host’s immune system and induce innate and adaptive immune responses against pathogens. It is also becoming apparent that the gut commensals are endowed with a capacity to alter immune responses in organs beyond the intestine, such as the lungs, highlighting the significance of the gut commensals in controlling systemic immunity. On the other hand, the host’s immune system possesses the ability to shape the repertoire of commensal microbes and contribute to the establishment of beneficial relationships with them. A better understanding of host-commensal interactions will be important for designing effective vaccines and therapeutics against pathogens. This Research Topic sheds light on our current understanding of the interplay between the host’s immune system and commensal microbes and how this interplay can be exploited for prophylactic and/or therapeutic strategies against pathogens.
An Elegant Defense
Author: Matt Richtel
Publisher: HarperCollins
Published: 2019-03-12
Total Pages: 448
ISBN-13: 0062698508
DOWNLOAD EBOOK →National Bestseller "A valuable read that will help you understand what it takes to stop COVID-19. … A super interesting look at the science of immunity.” —Bill Gates, Gates Notes Summer Reading List The Pulitzer Prize–winning New York Times journalist "explicates for the lay reader the intricate biology of our immune system" (Jerome Groopman, MD, New York Review of Books) From New York Times science journalist Matt Richtel, An Elegant Defense is an acclaimed and definitive exploration of the immune system and the secrets of health. Interweaving cutting-edge science with the intimate stories of four individual patients, this epic, first-of-its-kind book “give[s] lay readers a means of understanding what’s known so far about the intricate biology of our immune systems” (The Week). The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. It has been honed by evolution over millennia to face an almost infinite array of threats. For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders. An Elegant Defense effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to today’s laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. Drawing on extensive new interviews with dozens of world-renowned scientists, Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”
Colloidal Metal Oxide Nanoparticles
Author:
Publisher: Elsevier
Published: 2019-10-16
Total Pages: 608
ISBN-13: 0128133589
DOWNLOAD EBOOK →Colloidal Metal Oxide Nanoparticles: Synthesis, Characterization and Applications is a one-stop reference for anyone with an interest in the fundamentals, synthesis and applications of this interesting materials system. The book presents a simple, effective and detailed discussion on colloidal metal oxide nanoparticles. It begins with a general introduction of colloidal metal oxide nanoparticles, then delves into the most relevant synthesis pathways, stabilization procedures, and synthesis and characterization techniques. Final sections discuss promising applications, including bioimaging, biosensing, diagnostic, and energy applications—i.e., solar cells, supercapacitors and environment applications—i.e., the treatment of contaminated soil, water purification and waste remediation. Provides the most comprehensive resource on the topic, from fundamentals, to synthesis and characterization techniques Presents key applications, including biomedical, energy, electronic and environmental Discusses the most relevant techniques for synthesis, patterning and characterization
Abdominal Sepsis
Author: Massimo Sartelli
Publisher: Springer
Published: 2018-03-20
Total Pages: 405
ISBN-13: 3319597043
DOWNLOAD EBOOK →This book examines in detail the topic of sepsis, with a focus on intra-abdominal sepsis. Particular attention is devoted to source control in the management of the infection, antimicrobial therapy and sepsis support, which represent the cornerstones of treating patients with this problem. The importance of a multidisciplinary approach is highlighted not only by the instructive and informative sections on the acute manifestations of appendicitis, cholecystitis, and cholangitis, perforations and diverticulitis, Clostridium difficile infection and the role of candida in abdominal sepsis, but also by an extensive discussion of issues including antimicrobial resistance, damage control surgery, principles of antimicrobial therapy, hemodynamic support, adjunctive therapies, and thromboprophylaxis. Abdominal sepsis is the host’s systemic inflammatory response to intra-abdominal infections. It is associated with significant morbidity and mortality rates, and represents the second most common cause of sepsis-related mortality at intensive care units. Gathering contributions by authoritative experts from all around the world, this book will allow acute care surgeons, abdominal surgeons, intensive care clinicians, and students to broaden their understanding of intra-abdominal sepsis in daily clinical practice.
How Pathogenic Viruses Work
Author: Lauren Sompayrac
Publisher: Jones & Bartlett Learning
Published: 2002
Total Pages: 132
ISBN-13: 9780763720827
DOWNLOAD EBOOK →A clever, accessible overview that uses a survey of 12 of the most common viral infections, to teach the fundamental principles of human virology.
Bacterial Sensing and Signaling
Author: Mattias Collin
Publisher: Karger Medical and Scientific Publishers
Published: 2009-01-01
Total Pages: 239
ISBN-13: 3805591322
DOWNLOAD EBOOK →Over the last fifteen years it has become increasingly obvious that bacteria are not as simple and solitary as once believed. Rather, an accumulating body of work shows that bacteria are highly complicated and social organisms, constantly sensing their surroundings and altering both their environments and behaviors to ensure survival. Direct communication between bacteria turns out to be quite common, as are coordinated intra- and interspecies responses that include the formation of highly sophisticated microbial communities. In fact, threats to bacterial survival from assaults ranging from nutrient deprivation and oxygen depletion tothe defenses of eukaryotic hostsare all managed through the integration of a dizzying array of complex sensory and communication systems with the appropriate bacterial behaviors. This volume provides an update of the current knowledgeinthe expanding field ofbacterial sensing and signaling, highlighting its most important and interesting aspects. In twelve state-of-the-art articles, respected international experts address topics such as quorum sensing and secondary messengers, chemotaxis and magnetoaerotaxis, two-component phosphotransferase systems, bacterial virulence mechanisms, thermoregulation, and more. The final chapter represents a unique description of the tools available to manipulate many of the sensing and signaling systems described in this volume. Bacterial Sensing and Signaling is recommended reading for students, scientists and clinicians with interests in microbiology, immunology, ecology, biotechnology and a range of other disciplines.
Cancer RNome: Nature & Evolution
Author: Mansi Arora
Publisher: Springer
Published: 2018-11-02
Total Pages: 313
ISBN-13: 981131568X
DOWNLOAD EBOOK →In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..
The Bacteriophage and Its Behavior
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4
Author: Kenneth V. Honn
Publisher: Springer Science & Business Media
Published: 2013-12-01
Total Pages: 660
ISBN-13: 1461547938
DOWNLOAD EBOOK →This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.
