Oscillotherapeutics - Toward Real-Time Control of Pathological Oscillations in The Brain, 2nd edition

Oscillotherapeutics - Toward Real-Time Control of Pathological Oscillations in The Brain, 2nd edition PDF

Author: Yuichi Takeuchi

Publisher: Frontiers Media SA

Published: 2023-03-01

Total Pages: 115

ISBN-13: 2832512550

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Oscillatory brain activities reflect and affect network activities in the brain. They support many physiological functions from motor control to cognition and emotion. Abnormal oscillatory brain activities are commonly observed in neurological and psychiatric disorders including epilepsy, Parkinson’s disease, Alzheimer’s disease, schizophrenia, anxiety/trauma-related disorders, major depressive disorders, addiction, etc. Therefore, these disorders can be considered as common oscillation defects “oscillopathies” despite having distinct behavioral manifestations. Recent advances in brain activity measurements and analyses have allowed us to study the pathological oscillations of each disorder as a possible biomarker of symptoms. Furthermore, novel brain stimulation technologies will enable time- and space-targeted interventions of the pathological oscillations of both neurological and psychiatric disorders as possible therapeutic targets for regulating their symptoms. This Research Topic focused on understanding and controlling pathological oscillations in the brain will provide a comprehensive overview of pathological oscillations in neurological and psychiatric disorders. This Research Topic will also examine correlations or causal relationships between pathological oscillations and the symptoms of disorders with a view to the possible use of oscillations as biomarkers or therapeutic targets. Good animal models that accurately reflect neurological and psychiatric symptoms of patients are necessary for providing the proof-of-concept toward future translational research. Large-scale recording and reliable decoding technologies are crucial for discovering the correlations between pathological oscillations and some symptoms, while time- and space-targeted intervention technologies are necessary for studying their causal relationships, Such data will eventually allow the development of neuroprosthesis devices for pathological oscillations. Revealing the mechanisms of physiological oscillations is also important for the direction of this topic.

Diseases of the Nervous System

Diseases of the Nervous System PDF

Author: Harald Sontheimer

Publisher: Elsevier

Published: 2021-05-20

Total Pages: 502

ISBN-13: 0128213965

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The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. 2016 PROSE Award winner of the Best Textbook Award in Biological and Life Sciences Provides a focused tutorial introduction to the core diseases of the nervous system Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system Covers more than 40 diseases from the foundational science to the best treatment protocols Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience New Edition features two new chapters on Pain and Addiction

The Epilepsies

The Epilepsies PDF

Author: Chrysostomos P. Panayiotopoulos

Publisher: Springer

Published: 2005

Total Pages: 570

ISBN-13:

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This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.

Cardioprotection

Cardioprotection PDF

Author: Derek Hausenloy

Publisher: OUP Oxford

Published: 2009-08-20

Total Pages: 144

ISBN-13: 0191575488

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Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying each year. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems. This book focuses on the role of cardioprotection in surgery and the use of pharmacological therapies such as ACE-inhibitors, statins and beta-blockers in order to reduce the myocardial injury sustained by the patient and the significant risk of morbidity and mortality. It includes new cardioprotective strategies aimed at improving the clinical outcomes of patients in these settings, as well as current well-established methods for reducing myocardial injury in acute coronary syndrome patients.

The Basal Ganglia II

The Basal Ganglia II PDF

Author: Malcolm B. Carpenter

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 535

ISBN-13: 1468453475

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This volume was generated from papers presented at the Second Triennial Symposium of the International Basal Ganglia Society (IBAGS) held at the University of Victoria, British Columbia, July 21-23, 1986. The meeting was held as a satellite symposium following the XXX Congress of the International Union of Physiological Sciences at Vancouver. IBAGS was founded at a similar satellite symposium held in Lorne, Australia, organized by John S. McKenzie and sponsored by the University of Melbourne. The symposium held in Australia was attended by 50 scientists from 12 different countries. The results of the first symposium, edited by John S. McKenzie, Robert E. Kemm and Lynette N. Wilcock, were published by Plenum Press in 1984 under the title, The Basal Ganglia - Structure and Function. It was decided that the Society should meet on a triennial basis. The time and place for Second IBAGS Symposium were set by A.G. Phillips who served as Chairman of the Program Committee along with I. Divac, S.A. Greenfield and E.T. Rolls and J.S. McKenzie. Michael E. Corcoran of the Department of Psychology, University of Victoria served as the on-site coordinator and arranger for the Symposium. He was ably assisted by Ms. Morag McNeil who handled the details which made the meeting run smoothly.

The Cambridge Handbook of Infant Development

The Cambridge Handbook of Infant Development PDF

Author: Jeffrey J. Lockman

Publisher: Cambridge University Press

Published: 2020-08-13

Total Pages: 1104

ISBN-13: 1108663001

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This multidisciplinary volume features many of the world's leading experts of infant development, who synthesize their research on infant learning and behaviour, while integrating perspectives across neuroscience, socio-cultural context, and policy. It offers an unparalleled overview of infant development across foundational areas such as prenatal development, brain development, epigenetics, physical growth, nutrition, cognition, language, attachment, and risk. The chapters present theoretical and empirical depth and rigor across specific domains of development, while highlighting reciprocal connections among brain, behavior, and social-cultural context. The handbook simultaneously educates, enriches, and encourages. It educates through detailed reviews of innovative methods and empirical foundations and enriches by considering the contexts of brain, culture, and policy. This cutting-edge volume establishes an agenda for future research and policy, and highlights research findings and application for advanced students, researchers, practitioners, and policy-makers with interests in understanding and promoting infant development.

The Correlative Brain

The Correlative Brain PDF

Author: Jos J. Eggermont

Publisher: Springer Science & Business Media

Published: 2013-03-13

Total Pages: 319

ISBN-13: 3642510337

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This monograph is the result of a course given to graduate students and to the faculty of the Dept. of Medical Physics and Biophysics of Nijmegen University, Nijmegen, The Netherlands, in the fall of 1984 and 1985. The course was intended to put together experi ment, theory, and analysis methods in order to study neural in teraction and coding in the brain. The following pages give a survey of neural interaction and its experimental substrate: cor related neural activity. The basic reason for restricting myself to vertebrate brains was to keep the material concise. As the text developed, however, it became more of a review, than a research monograph, in the attempt to balance theoretical and experimen tal aspects in brain research. Consequently, the book can be read from various points of view: that of requiring an overview of theories and theoretical principles, or an overview of experimental studies in neural interaction and the methods that can be used, or with the conviction that theory and experiment cannot be separat ed. In the latter case the book should be read from beginning to end. A way to read through the theoretical sections and the ex perimental sections of the book is presented in the following flow chart; Theory: /Chap. 2 -Chap. 4 -Chap. 5 ___ ~ Introduction -+ Chap. 1 \, Chap. 10 -+ Chap. 14 Experim~Chap. 3 -Chap. 6 -Chap. 7 -Chap. 8 ~ Chap.

Brain Stimulation

Brain Stimulation PDF

Author: Irving Reti

Publisher: John Wiley & Sons

Published: 2015-05-11

Total Pages: 364

ISBN-13: 111856829X

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Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise particularly in the last two decades. Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brainstimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activity dependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation. Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians.

Fluorescent Probes

Fluorescent Probes PDF

Author:

Publisher: Academic Press

Published: 2021-05-13

Total Pages: 284

ISBN-13: 0128235438

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Fluorescent Probes, Volume 48 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics, including Hydrogel microarray technology as a tool for clinical diagnostics, The use of probes and bacteriophages for bacteria detection, Probes used with point-of-care microfluidic devices for pathogen detection, Methods for combining FIB/SEM with three-dimensional fluorescence microscopy using CLEM approaches, Probes and Microbes, Microbial signatures associated with cancers, Fluorescent Aptamers for Detection and Treatment of Pathogenic Bacteria and Cancer, Labelled and Unlabeled Probes for Pathogen Detection with Molecular Biology Methods and Biosensors, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Microbiology series