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Author: OECD
Publisher: OECD Publishing
Published: 2004-11-23
Total Pages: 8
ISBN-13: 9264071067
DOWNLOAD EBOOK →The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author: OECD
Publisher: OECD Publishing
Published: 2004-11-23
Total Pages: 8
ISBN-13: 9264071083
DOWNLOAD EBOOK →This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Author: OECD
Publisher: OECD Publishing
Published: 2021-06-17
Total Pages: 28
ISBN-13: 9264242848
DOWNLOAD EBOOK →This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author: OECD
Publisher: OECD Publishing
Published: 2015-07-28
Total Pages: 8
ISBN-13: 9264242678
DOWNLOAD EBOOK →This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Author: OECD
Publisher: OECD Publishing
Published: 2004-11-01
Total Pages: 31
ISBN-13: 9264078797
DOWNLOAD EBOOK →This guidance document has been prepared to support technical aspects of the OECD skin absorption test guidelines. In particular is discusses the various aspects of in vivo vs. in vitro testing.
Author: OECD
Publisher: OECD Publishing
Published: 1981-05-12
Total Pages: 9
ISBN-13: 9264070761
DOWNLOAD EBOOK →This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...
Author: OECD
Publisher: OECD Publishing
Published: 2015-07-28
Total Pages: 13
ISBN-13: 9264242791
DOWNLOAD EBOOK →This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.
Author: OECD
Publisher: OECD Publishing
Published: 2017-10-09
Total Pages: 13
ISBN-13: 9264070583
DOWNLOAD EBOOK →This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Author: OECD
Publisher: OECD Publishing
Published: 2019-06-18
Total Pages: 29
ISBN-13: 9264264612
DOWNLOAD EBOOK →The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Author: OECD
Publisher: OECD Publishing
Published: 1992-07-17
Total Pages: 12
ISBN-13: 9264070664
DOWNLOAD EBOOK →This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...
