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Ocular Circulation and Neovascularization

Author: D. Benezra

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 555

ISBN-13: 9400933371

Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif·ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand & upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook

The Ocular Circulation

Author: Jeffrey W. Kiel

Publisher: Morgan & Claypool Publishers

Published: 2011

Total Pages: 82

ISBN-13: 1615041680

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This presentation describes the unique anatomy and physiology of the vascular beds that serve the eye. The needs for an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures pose significant challenges for the vasculature to provide nutrients and remove metabolic waste. To meet these needs, the ocular vascular beds are confined to the periphery of the posterior two thirds of the eye and a surrogate circulation provides a continuous flow of aqueous humor to nourish the avascular cornea, lens and vitreous compartment. The production of aqueous humor (and its ease of egress from the eye) also generates the intraocular pressure (IOP), which maintains the shape of the eye. However, the IOP also exerts a compressing force on the ocular blood vessels that is higher than elsewhere in the body. This is particularly true for the intraocular veins, which must have a pressure higher than IOP to remain patent, and so the IOP is the effective venous pressure for the intraocular vascular beds. Consequently, the ocular circulation operates at a lower perfusion pressure gradient than elsewhere in the body and is more at risk for ischemic damage when faced with low arterial pressure, particularly if IOP is elevated. This risk and the specialized tissues of the eye give rise to the fascinating physiology of the ocular circulations. Table of Contents: Introduction / Anatomy / Blood flow measuring techniques / Ocular perfusion pressure, IOP and the ocular Starling resistor effect / Ocular blood flow effects on IOP / Local control of ocular blood flow / Neural control of ocular blood flow / Summary

Ocular Blood Flow

Author: Leopold Schmetterer

Publisher: Springer Science & Business Media

Published: 2012-06-14

Total Pages: 451

ISBN-13: 3540694692

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Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.

The Retinal Circulation

Author: George N. Wise

Publisher: HarperCollins Publishers

Published: 1971

Total Pages: 584

ISBN-13:

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Ocular Vascular Occlusive Disorders

Author: Sohan Singh Hayreh

Publisher: Springer

Published: 2015-02-18

Total Pages: 863

ISBN-13: 3319127810

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This book provides a comprehensive account of the pathogenesis, clinical features, and management of ocular vascular occlusive disorders, with the focus very much on the scientific evidence. This offers a sound basis for addressing the many controversies that surround these disorders, which collectively constitute the most common cause of visual impairment or blindness. The book is divided into two sections, the first of which addresses the basic science and encompasses vascular anatomy, blood supply and flow, and retinal tolerance time to acute ischemia. The second, clinical, section covers the presentation, clinical features, diagnosis, and treatment of the full range of vascular occlusive disorders of the retina, the choroid, the anterior segment of the eye, ophthalmic manifestations of carotid artery disease and the optic nerve. Ocular Vascular Occlusive Disorders, written by a distinguished world leader in the field, will be invaluable for general ophthalmologists, and particularly for retina specialists, neuro-ophthalmologists, and researchers.

4th International Symposium on Ocular Circulation and Neovascularization

Author:

Publisher:

Published: 1995

Total Pages: 196

ISBN-13:

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High Resolution Imaging in Microscopy and Ophthalmology

Author: Josef F. Bille

Publisher: Springer

Published: 2019-08-13

Total Pages: 407

ISBN-13: 3030166384

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This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Atlas of Ocular Blood Flow

Author: Alon Harris

Publisher: Butterworth-Heinemann

Published: 2003

Total Pages: 150

ISBN-13:

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This text examines the vascular anatomy and physiology of the eye as well as the assessment of ocular circulation in health and disease. It offers a cutting-edge analysis of the eye's blood supply and how it is affected by conditions such as glaucoma, age-related macular degeneration, and diabetic retinopathy. 425 illustrations -- including 250 in full color -- detail anatomy, techniques, the results of imaging studies, and more. Provides a cutting-edge analysis of the eye's blood supply and how it is affected by conditions such as glaucoma, age-related macular degeneration, and diabetic retinopathy. Describes the latest noninvasive methods for measuring blood flow, and explains how to use this advanced technology to evaluate patients. Features more than 435 illustrations-over 345 in full color-that richly depict anatomy, techniques, imaging findings, and more. Offers the expertise of authors who have been involved extensively in the design and clinical application of new technologies for the assessment of ocular circulation.

Control of Ocular Circulation

Author: Esmeralda Delgado

Publisher: LAP Lambert Academic Publishing

Published: 2015-04-20

Total Pages: 108

ISBN-13: 9783659698262

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In this volume Prof. Dr. Esmeralda Delgado summarizes the content of the research that led to her PhD thesis under the theme of the local control of ocular circulation in an isolated model of rabbit eye. The eye is our window to the world and the loss of its functionality has a profound and devastating effect on the way we interact with the environment around us. The ocular circulation comprises two compartments: a retinal and a choroidal compartment and the control of ocular circulation is a vital component in the maintenance of retinal homeostasis. Understanding the local control mechanisms is a key factor to the development of effective treatments to restore a normal retinal blood flow in disease situations. In this work we developed an experimental model of isolated rabbit eye to help clarifying the local mechanisms of control of ocular circulation, independently of other interferences present in an "in vivo" model. This in situ model mimics most of the vascular connections present in the living animal, allowing the study of the intrinsic mechanisms of regulation of ocular circulation yet eliminating neural influences.

Ocular and Visual Physiology

Author: Simon E. Skalicky

Publisher: Springer

Published: 2015-11-03

Total Pages: 372

ISBN-13: 9812878467

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This book meets the growing demand among ophthalmologists, optometrists and orthoptists, in training and in practice, as well as visual neuroscientists, to have a clear, succinct and well-written textbook to objectively cover the subject of ocular and visual physiology. Ocular and visual physiology is a core knowledge component for these disciplines, and yet is often difficult to understand. However, this book clearly conveys the simple elegance of the relationship between structure and function that is the hallmark of understanding the physiology of the eye and visual system. Ocular and Visual Physiology – Clinical Application is essential reading for any one hoping to have a clear understanding of the subject. Students will find it a great resource to pass their exams. Each of the chapters has been independently reviewed and edited by an expert in the field with a clinical or visual scientific academic background. The text is based on the latest publications in peer-reviewed journals that are closely referenced within the body of the text.