Author: Gilbert Thompson
Publisher: World Scientific
Published: 2011-12-28
Total Pages: 372
ISBN-13: 1848169523
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Tony Seed, Gilbert Thompson, Jackie Downs and John MacDermot at the book's launch in London This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise. Contents:The Discovery of Insulin (Robert Tattersall)The Discovery of the Cure for Pernicious Anaemia, Vitamin B12 (A Victor Hoffbrand)The Discovery of Penicillin (Eric Sidebottom)The Introduction of Cardiac Catheterization (Tony Seed)The Discovery of the Structure of DNA (James Scott and Gilbert Thompson)The Interpretation of the Genetic Code (John MacDermot and Ellis Kempner)The Discovery of Neuropeptides and Radioimmunoassay of Peptide Hormones (Jaimini Cegla and Stephen Bloom)The Development of Computer-Assisted Tomography (Adrian M K Thomas)The Discovery of Prostaglandins (Rod Flower)The Antibody Problem and the Generation of Monoclonal Antibodies (Herman Waldmann and Celia P Milstein)The Discovery of the LDL Receptor and Its Role in Cholesterol Metabolism (Gilbert Thompson)The Invention of the Polymerase Chain Reaction and Use of Site-Directed Mutagenesis (Anne K Soutar)The Discovery of the Pathophysiological Role of Nitric Oxide in Blood Vessels (Keith M Channon)The Discovery of Helicobacter pylori (Chris Hawkey)The Discovery of RNA Interference — Gene Silencing by Double-Stranded RNA (Richard P Hull and Timothy J Aitman) Readership: Students, undergraduates, graduates, professionals and members of the general public interested in the impact of Nobel Prize-winning discoveries in medicine. Keywords:Insulin;Vitamin B12;Penicillin;Cardiac Catheterisation;DNA;Genetic Code;Peptide Hormones;Computer Assisted Tomography;Prostaglandins;Monoclonal Antibodies;LDL Receptor;Polymerase Chain Reaction;Nitric Oxide;Helicobacter Pylori;Gene-SilencingKey Features:Many of the authors in this book have personal knowledge of the Nobel Laureates they write aboutAll authors are distinguished authorities in their own fields of studyNo other book has brought together the Nobel Prizes in such a way-highlighting the greatest influences on the practice of Medicine, dating from the discovery of insulin in 1923 to the description of the gene-silencing effect of double-stranded RNA in 2006Reviews:“Clear annotation and ample documentation add to the value of this important book.”CHOICE “This is an interesting book aimed at a scientific reader with some knowledge of biochemistry and physiology. ”Bulletin of The Royal College of Pathologists “Many see the Nobel Prize as an award for original discoveries that enhance understanding, but these essays show how much medicine can deliver for human good and with almost immediate application. What characterizes Nobel Prizes That Changed Medicine is the extraordinary percipience of those who draw from a vast electric range of observations in the foreground of practice and crystallize their scientific ideas uncontaminated by dogma.”Clinical Medicine
